Open Access
Effects of long-term consumption of broccoli sprouts on inflammatory markers in overweight subjects
(Elsevier, 2018-03-13) López-Chillón, María Teresa; Carazo-Díaz, Carmen; Prieto-Merino, David; Zafrilla, Pilar; Moreno, Diego A.; Villaño Valencia, Débora; Agronomía, Biotecnología y Alimentación; Agronomia, Bioteknologia eta Elikadura
Background & aims. Broccoli sprouts represent an interesting choice of healthy food product as they are rich in glucosinolates and their cognate bioactive metabolites, isothiocyanates able to counteract the negative effects of diverse pathologies. As obesity is linked to an inflammatory component, the aim of the study was to evaluate the anti-inflammatory action of broccoli sprouts in overweight adult subjects. Methods. An in vivo controlled study was performed in 40 healthy overweight subjects (ClinicalTrials.gov ID NCT 03390855). Treatment phase consisted on the consumption of broccoli sprouts (30 g/day) during 10 weeks and the follow-up phase of 10 weeks of normal diet without consumption of these broccoli sprouts. Anthropometric parameters as body fat mass, body weight, and BMI were determined. Inflammation status was assessed by measuring levels of TNF-α, IL-6, IL-1β and C-reactive protein. Results. IL-6 levels significantly decreased (mean values from 4.76 pg/mL to 2.11 pg/mL with 70 days of broccoli consumption, p < 0.001) and during control phase the inflammatory levels were maintained at low grade (mean values from 1.20 pg/mL to 2.66 pg/mL, p < 0.001). C-reactive protein significantly decreased as well. Conclusions. This study represents an advance in intervention studies as the broccoli sprouts were included in a daily dietary pattern in quantities that reflect a real consumption. Further studies are necessary to elucidate the role of this healthy rich and nutritious food product, but these promising results support the current evidence on the healthy properties of Brassica varieties.
Open Access
Revalorisation of broccoli crop surpluses and field residues: novel ingredients for food industry uses
(Springer, 2023) Villaño Valencia, Débora; Fernández Pan, Idoya; Arozarena Martinicorena, Íñigo; Ibáñez Moya, Francisco C.; Virseda Chamorro, Paloma; Beriain Apesteguía, María José; Institute on Innovation and Sustainable Development in Food Chain - ISFOOD; Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa
Research on the management of broccoli crop residues and surpluses is critical for improving agricultural practices, optimizing food industrial manufacture, and contributing to better human nutrition. The objective of this study was to obtain novel ingredients based on these residues and surpluses for a wide range of applications in the food industry. The efect of air-drying (60 °C or 80 °C) applied to feld residues (broccoli stalks), mimicking industrial conditions, was compared with dehydration by freeze-drying applied to these same feld residues and to crop surpluses (broccoli whole plant). Thus, diferent broccoli fours were obtained and characterised for technological and biological properties including colour, antioxidant activity, nutrients, total polyphenol content, and content of glucosinolates. Flours from feld residues showed high levels of dietary fbre (≈22% dry weight). Broccoli crop surpluses fours had relevant contents of glucosinolates (≈13 mg/g dry weight). Therefore, within the framework of the circular economy, these fours are proposed to revalorise the two main broccoli crop discarded fractions. Such fours could be used in a realistic and simple way by the agri-food industries interested in the development of healthy and conscience foodstufs, in a cost-efcient manner.
Open Access
Bioavailability of broccoli sprouts in different human overweight populations
(Elsevier, 2019-06-10) Villaño Valencia, Débora; López-Chillón, María Teresa; Zafrilla, Pilar; Moreno, Diego A.; Agronomía, Biotecnología y Alimentación; Agronomia, Bioteknologia eta Elikadura
Broccoli sprouts rich in glucosinolates have shown interesting properties mitigating the inflammatory status linked to obesity. Studies performed in healthy lean subjects have shown that these compounds possess good bioavailability, however long-term studies in overweight populations are scarce. The aim of this study was to evaluate the bioavailability of broccoli sprouts in overweight adults: men, non-menopausal women and post-menopausal women. An in vivo controlled parallel study was performed in 69 healthy overweight subjects that consumed broccoli sprouts (30 g/day) during 5 weeks, with a follow-up phase of 5 weeks of normal diet without broccoli sprouts. Trial registered at ClinicalTrials.gov as NCT03390855. Metabolites from glutathione detoxification pathway increased in all groups after 5 weeks of broccoli consumption, especially in post-menopausal women (Sulphoraphane-N-Acetyl cysteine levels from 0.0656 nmol/mg creatinine to 1.8191 nmol/mg creatinine, p < 0.001) and similar behaviour was observed for Sulphoraphane and Sulphoraphane-Cysteine. Post-menopausal condition was associated with higher levels of metabolites.
Open Access
The role of brassica bioactives on human health: are we studying it the right way?
(MDPI, 2020) Quirante-Moya, Sarai; García-Ibáñez, Paula; Quirante-Moya, Francisco; Villaño Valencia, Débora; Moreno, Diego A.; Agronomía, Biotecnología y Alimentación; Agronomia, Bioteknologia eta Elikadura; Institute on Innovation and Sustainable Development in Food Chain - ISFOOD
Brassica vegetables and their components, the glucosinolates, have been suggested as good candidates as dietary coadjutants to improve health in non-communicable diseases (NCDs). Different preclinical and clinical studies have been performed in the last decade; however, some concerns have been posed on the lack of established and standardized protocols. The different concentration of bioactive compounds used, time of intervention or sample size, and the lack of blinding are some factors that may influence the studies’ outcomes. This review aims to analyze the critical points of the studies performed with Brassica-related biomolecules and propose some bases for future trials in order to avoid biases.

Villaño Valencia, Débora

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