Sánchez Villegas, María Almudena

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https://academica-e.unavarra.es/handle/2454/49971

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Sánchez Villegas

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María Almudena

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Ciencias de la Salud

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IS-FOOD. Research Institute on Innovation & Sustainable Development in Food Chain

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0000-0001-7733-9238

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751024

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Author: Cabrera, Claudio × Subject: Quality of life ×

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    PublicationOpen Access
    Effect of a dietary intervention based on the mediterranean diet on the quality of life of patients recovered from depression: analysis of the PREDIDEP randomized trial
    (Elsevier, 2023) Cabrera Suárez, Beatriz; Lahortiga Ramos, Francisca; Sayón-Orea, Carmen; Hernández-Fleta, José L.; González Pinto, Ana; Molero, Patricio; Vega-Pérez, Rosario; Sánchez Villegas, María Almudena; Cabrera, Claudio; Pla, Jorge; Chiclana Actis, Carlos; Vega-Pérez, P.; Navarro, S.; Ortuño, Felipe; Florido Rodríguez, Mónica; Institute on Innovation and Sustainable Development in Food Chain - ISFOOD
    Introduction: There is substantial evidence supporting that improving diet quality leads to improved healthrelated quality of life (HRQoL). Our major aim was to assess the effectiveness of a Mediterranean diet–based nutritional intervention to improve HRQoL in the context of a secondary prevention trial of depression. Secondarily to assess its effectiveness among adults aged 60 or more years. Methods: The PREDIDEP study is a 2-year multicentre, randomized, single-blinded nutritional trial. At baseline and at 1-year and 2-year follow-up, SF-36 health survey questionnaire was collected to evaluate participants' HRQoL (total and specific range for each of the 8 dimensions: 0 to 100 points). Mixed effect linear models were used to assess changes in HRQoL according to adherence to the Mediterranean diet. The trial was registered at ClinicalTrials.gov NCT03081065. Results: After 2 years of intervention, the Mediterranean Diet intervention group compared to control group (without nutritional intervention, only usual clinical care) showed an improvement in some dimensions of HRQoL such as Mental Health (7.22; 95 % CI = 2.22–12.22) (between-group difference: 6.79; 95 % CI − 0.14–13.73, p = 0.055); Vitality (9.51; 95 % CI = 4.00–15.03) (between-group difference: 9.00; 95 % CI 1.75–16.25, p = 0.020); Mental Summary Component (2.83; 95 % CI = 0.55–5.11) (between-group difference: 1.17; 95 % CI = − 1.96–4.30, p = 0.462); and General Health (10.70; 95 % CI = 5.58–15.81) (between-group difference: 6.20; 95 % CI = − 0.89–13.28, p = 0.086). Similar results were observed for participants aged 60 or more years. Conclusion: The intervention based on Mediterranean diet in patients with previous depression seems to be effective in improving HRQoL, especially the mental dimensions. This effect is also observed among participants aged 60 or more years.