Person: Sánchez Villegas, María Almudena
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Sánchez Villegas
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María Almudena
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Ciencias de la Salud
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IS-FOOD. Research Institute on Innovation & Sustainable Development in Food Chain
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0000-0001-7733-9238
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812351
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Publication Open Access Health-related quality of life and mortality in the 'Seguimiento Universidad de Navarra' prospective cohort study(Elsevier, 2023) López-Herreros, J.; Martínez González, Miguel Ángel; Gea, A.; Sánchez Villegas, María Almudena; Dierssen Sotos, Trinidad; Jiménez-Moleón, J. J.; Ruiz Canela, Miguel; Toledo, Estefanía; Institute on Innovation and Sustainable Development in Food Chain - ISFOODObjective: To study the association between health-related quality of life (HRQoL) and all-cause mortality in a healthy middle-aged Mediterranean cohort. Methods: We included 15,390 participants –mean age 42.8 years at first HRQoL ascertainment, all university graduates–. HRQoL was assessed with the self-administered Medical Outcomes Study Short Form-36 (SF-36) twice, with a 4-year gap. We used multivariable-adjusted Cox regression models to address the relation between self-reported health and Physical or Mental Component Summary (PCS-36 or MCS-36) and mortality, and their interaction with prior comorbidities or adherence to the Mediterranean diet (MedDiet). Results: Over 8.7 years of median follow-up time, 266 deaths were identified. Hazard ratio (HR) for the excellent vs. poor/fair category in self-reported health was 0.30 (95 % confidence interval (CI), 0.16–0.57) in the model with repeated measurements of HRQoL. Both the PCS-36 (HRquartile4(Q4)vs.Q1 0.57 [95%CI, 0.36–0.90], ptrend < 0.001; HRper+10points: 0.64 [95%CI, 0.54–0.75]) and the MCS-36 (HRQ4vs.Q1 0.67 [95%CI, 0.46–0.97], ptrend = 0.025; HRper+10points: 0.86 [95%CI, 0.74–0.99]) were inversely associated with mortality in the model with repeated measurements of HRQoL. Previous comorbidities or adherence to the MedDiet did not modify these associations. Conclusions: Self-reported HRQoL –assessed as self-reported health, PCS-36 and MCS-36– obtained with the Spanish version of the SF-36 were inversely associated with mortality risk, regardless of the presence of previous comorbidities or adherence to the MedDiet.Publication Open Access Sedentary behaviors and risk of depression in the Seguimiento Universidad de Navarra cohort: the SUN Project(Escola Nacional de Saude Pública Sergio Arouca, 2022) Pimenta, Adriano Marçal; Deus Mendonça, Raquel de; Lahortiga Ramos, Francisca; Fernández-Lázaro, César; Martínez González, Miguel Ángel; Sánchez Villegas, María Almudena; Ciencias de la Salud; Osasun Zientziak; Gobierno de Navarra / Nafarroako GobernuaThe study aimed to prospectively examine the association between different sedentary behaviors and the risk of depression. We included 12,691 Spanish university graduates (mean age: 36.7 year; SD: 11.5), participants of the Seguimiento Universidad de Navarra cohort (the SUN Project), initially free of depression who were followed-up for a median of 10.9 years. Based on items presented in our baseline questionnaire, time spent in four sedentary behaviors (hours/day) were evaluated: overall sitting time; TV-viewing; computer use; and driving. Participants were classified as incident cases of depression if they reported a physician diagnosis of depression in at least one of the follow-up assessments conducted after the first two years of follow-up. Cox regression models were used to assess the relationship between sedentary behaviors and depression. A total of 560 incident cases of depression were identified during follow-up. We found no significant association between overall sitting time, TV-viewing or driving and risk of depression. On the other hand, computer use was directly associated with the risk of developing depression during the follow-up (p-value for trend = 0.020), with the participants in the highest quartile of computer use (3.64 to 10 hours/week) having a higher risk of developing depression (HR = 1.33; 95%CI: 1.05-1.70) than those in the lowest quartile (0 to 0.25 hours/week) after adjusting for potential confounders. Prolonged use of computer was independently associated with an increased risk of developing depression among young middle-aged adult university graduates from a Spanish cohort.Publication Open Access Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study(Public Library of Science, 2022) Martín Peláez, Sandra; Serra-Majem, Lluis; Cano Ibáñez, Noemí; Martínez González, Miguel Ángel; Salas-Salvadó, Jordi; Corella, Dolores; Lassale, Camille; Martínez, Jose Alfredo; Alonso Gómez, Ángel M.; Wärnberg, Julia; Vioque, Jesús; Romaguera, Dora; López Miranda, José; Estruch, Ramón; Tinahones, Francisco J.; Lapetra, José; Fernández-Aranda, Fernando; Bueno Cavanillas, Aurora; Tur, Josep A.; Martín, Vicente; Pintó, Xavier; Delgado Rodríguez, Miguel; Matía, Pilar; Vidal, Josep; Vázquez, Clotilde; Daimiel, Lidia; Ros, Emilio; Toledo, Estefanía; Nishi, Stephanie K.; Sorli, Jose V.; Malcampo, Mireia; Zulet, María Ángeles; Moreno Rodríguez, Anaí; Cueto Galán, Raquel; Vivancos Aparicio, Diego; Colom, Antoni; García-Rios, Antonio; Casas, Rosa; Bernal López, M. Rosa; Santos Lozano, José Manuel; Vázquez, Zenaida; Gómez-Martínez, Carlos; Ortega Azorín, Carolina; Val, José Luis del; Abete, Itziar; Goikoetxea Bahon, Amaia; Pascual, Elena; Becerra-Tomás, Nerea; Chillarón, Juan J.; Sánchez Villegas, María Almudena; Institute on Innovation and Sustainable Development in Food Chain - ISFOODBackground Cardio-vascular disease and depression are thought to be closely related, due to shared risk factors. The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and depressive status in a population (55-75 years) with metabolic syndrome (MetS) from the PREDIMED-Plus trial. Methods and findings Participants were classified into three groups of CVR according to the Framingham-based REGICOR function: (1) low (LR), (2) medium (MR) or (3) high/very high (HR). The Beck Depression Inventory-II (BDI-II) was used to assess depressive symptoms at baseline and after 2 years. The association between CVR and depressive status at baseline (n = 6545), and their changes after 2 years (n = 4566) were evaluated through multivariable regression models (logistic and linear models). HR women showed higher odds of depressive status than LR [OR (95% CI) = 1.78 (1.26, 2.50)]. MR and HR participants with total cholesterol <160 mg/mL showed higher odds of depression than LR [OR (95% CI) = 1.77 (1.13, 2.77) and 2.83 (1.25, 6.42) respectively)] but those with total cholesterol ¿280 mg/mL showed lower odds of depression than LR [OR (95% CI) = 0.26 (0.07, 0.98) and 0.23 (0.05, 0.95), respectively]. All participants decreased their BDI-II score after 2 years, being the decrease smaller in MR and HR diabetic compared to LR [adjusted mean±SE = -0.52±0.20, -0.41 ±0.27 and -1.25±0.31 respectively). MR and HR participants with total cholesterol between 240-279 mg/mL showed greater decreases in the BDI-II score compared to LR (adjusted mean±SE = -0.83±0.37, -0.77±0.64 and 0.97±0.52 respectively). Conclusions Improving cardiovascular health could prevent the onset of depression in the elderly. Diabetes and total cholesterol in individuals at high CVR, may play a specific role in the precise response.Publication Open Access Dairy product consumption and changes in cognitive performance: two-year analysis of the PREDIMED-Plus Cohort(Wiley, 2022) Ni, Jiaqi; Nishi, Stephanie K.; Babio, Nancy; Martínez González, Miguel Ángel; Corella, Dolores; Castañer, Olga; Martínez, Jose Alfredo; Alonso Gómez, Ángel M.; Gómez-Gracia, Enrique; Vioque, Jesús; Romaguera, Dora; López Miranda, José; Estruch, Ramón; Tinahones, Francisco J.; Lapetra, José; Serra-Majem, Lluis; Bueno Cavanillas, Aurora; Tur, Josep A.; Martín-Sánchez, Vicente; Pintó, Xavier; Gaforio, José J.; Barabash Bustelo, Ana; Vidal, Josep; Vázquez, Clotilde; Daimiel, Lidia; Ros, Emilio; Toledo, Estefanía; Coltell, Oscar; Gómez-Martínez, Carlos; Zomeño, María Dolores; Donat Vargas, Carolina; Goicolea-Güemez, Leire; Bouzas, Cristina; García de la Hera, Manuela; Chaplin, Alice; García-Rios, Antonio; Casas, Rosa; Cornejo-Pareja, Isabel; Santos Lozano, José Manuel; Rognoni, Teresa; Saiz, Carmen; Paz-Graniel, Indira; Malcampo, Mireia; Sánchez Villegas, María Almudena; Salaverria-Lete, Itziar; García-Arellano, Ana; Schröder, Helmut; Salas-Salvadó, Jordi; Institute on Innovation and Sustainable Development in Food Chain - ISFOODScope: Dairy consumption has been suggested to impact cognition; however, evidence is limited and inconsistent. This study aims to longitudinally assess the association between dairy consumption with cognitive changes in an older Spanish population at high cardiovascular disease risk. Methods and results: Four thousand six hundred sixty eight participants aged 55–75 years, completed a validated food frequency questionnaire at baseline and a neuropsychological battery of tests at baseline and 2-year follow-up. Multivariable linear regression models are used, scaled by 100 (i.e., the units of β correspond to 1 SD/100), to assess associations between baseline tertile daily consumption and 2-year changes in cognitive performance. Participants in the highest tertile of total milk and whole-fat milk consumption have a greater decline in global cognitive function (β: –4.71, 95% CI: –8.74 to –0.69, p-trend = 0.020 and β: –6.64, 95% CI: –10.81 to –2.47, p-trend = 0.002, respectively) compared to those in the lowest tertile. No associations are observed between low fat milk, yogurt, cheese or fermented dairy consumption, and changes in cognitive performance. Conclusion:Results suggest there are no clear prospective associations between consumption of most commonly consumed dairy products and cognition, although there may be an association with a greater rate of cognitive decline over a 2-year period in older adults at high cardiovascular disease risk for whole-fat milk.