Person: Sánchez Villegas, María Almudena
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Sánchez Villegas
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María Almudena
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Ciencias de la Salud
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IS-FOOD. Research Institute on Innovation & Sustainable Development in Food Chain
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0000-0001-7733-9238
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812351
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Publication Open Access Effect of a dietary intervention based on the mediterranean diet on the quality of life of patients recovered from depression: analysis of the PREDIDEP randomized trial(Elsevier, 2023) Cabrera Suárez, Beatriz; Lahortiga Ramos, Francisca; Sayón-Orea, Carmen; Hernández-Fleta, José L.; González Pinto, Ana; Molero, Patricio; Vega-Pérez, Rosario; Sánchez Villegas, María Almudena; Cabrera, Claudio; Pla, Jorge; Chiclana Actis, Carlos; Vega-Pérez, P.; Navarro, S.; Ortuño, Felipe; Florido Rodríguez, Mónica; Institute on Innovation and Sustainable Development in Food Chain - ISFOODIntroduction: There is substantial evidence supporting that improving diet quality leads to improved healthrelated quality of life (HRQoL). Our major aim was to assess the effectiveness of a Mediterranean diet–based nutritional intervention to improve HRQoL in the context of a secondary prevention trial of depression. Secondarily to assess its effectiveness among adults aged 60 or more years. Methods: The PREDIDEP study is a 2-year multicentre, randomized, single-blinded nutritional trial. At baseline and at 1-year and 2-year follow-up, SF-36 health survey questionnaire was collected to evaluate participants' HRQoL (total and specific range for each of the 8 dimensions: 0 to 100 points). Mixed effect linear models were used to assess changes in HRQoL according to adherence to the Mediterranean diet. The trial was registered at ClinicalTrials.gov NCT03081065. Results: After 2 years of intervention, the Mediterranean Diet intervention group compared to control group (without nutritional intervention, only usual clinical care) showed an improvement in some dimensions of HRQoL such as Mental Health (7.22; 95 % CI = 2.22–12.22) (between-group difference: 6.79; 95 % CI − 0.14–13.73, p = 0.055); Vitality (9.51; 95 % CI = 4.00–15.03) (between-group difference: 9.00; 95 % CI 1.75–16.25, p = 0.020); Mental Summary Component (2.83; 95 % CI = 0.55–5.11) (between-group difference: 1.17; 95 % CI = − 1.96–4.30, p = 0.462); and General Health (10.70; 95 % CI = 5.58–15.81) (between-group difference: 6.20; 95 % CI = − 0.89–13.28, p = 0.086). Similar results were observed for participants aged 60 or more years. Conclusion: The intervention based on Mediterranean diet in patients with previous depression seems to be effective in improving HRQoL, especially the mental dimensions. This effect is also observed among participants aged 60 or more years.Publication Open Access Mediterranean diet-based intervention to improve depressive symptoms: analysis of the PREDIDEP randomized trial(Taylor and Francis Group, 2023) Cabrera Suárez, Beatriz; Hernández-Fleta, José L.; Molero, Patricio; González Pinto, Ana; Lahortiga Ramos, Francisca; Cabrera, Claudio; Chiclana Actis, Carlos; Sánchez Villegas, María Almudena; PREDI-DEP investigators; Institute on Innovation and Sustainable Development in Food Chain - ISFOODBackground:The effect of an intervention based on Mediterranean diet on reducing recurrencerisk or subsyndromal depressive symptoms in recovered depressed patients has not beenexplored.Methods:The PREDIDEP study was a two-year randomized trial designed to assess the effect of theMediterranean Diet enriched with extra virgin olive oil on depression recurrence. At baseline and atfour, eight, 16, 20, and 24 months of follow-up, depressive symptoms were evaluated through theBeck Depression inventory. Cox regression analysis wasfitted to assess the role of dietaryintervention on the risk of depression recurrence. Mixed effects linear models were used toassess changes in depressive subsyndromal symptoms according to the intervention.Results::After two years of intervention, the dietary intervention group (n= 103) compared to thecontrol group (n= 93) showed no differences regarding depression recurrence risk as mainoutcome. As secondary outcomes, an improvement of depressive symptoms was yielded at four(−2.15; 95% CI =−4.00 to−0.29) and eight months (−2.42; 95% CI =−4.17 to−0.67) in theintervention group, with no changes in control group. Moreover, at 20 months, significantdifferences were found between groups (−3.35; 95% CI =−6.08 to−0.61).Conclusions: An intervention with Mediterranean diet in patients with previous depressiveepisodes might contribute to the reduction of depressive subsyndromal symptoms.Publication Open Access Effectiveness of a remote nutritional intervention to increase the adherence to the Mediterranean diet among recovered depression patients(Taylor & Francis, 2022) Cabrera Suárez, Beatriz; Pla, Jorge; González Pinto, Ana; Hernández, José; Chiclana Actis, Carlos; Ortuño, Felipe; Florido Rodríguez, Mónica; Sánchez Villegas, María Almudena; Institute on Innovation and Sustainable Development in Food Chain - ISFOOD; Universidad Pública de Navarra / Nafarroako Unibertsitate PublikoaBackground: There is substantial evidence supporting that remote interventions are useful to change dietary habits. However, the effect of a remote intervention based on Mediterranean diet (MD) in depressive patients has been less explored. Objective: This study aims to assess the effectiveness of a remotely provided Mediterranean dietbased nutritional intervention in the context of a secondary prevention trial of depression. Methods: The PREDIDEP study was a 2-year multicenter, randomized, single-blinded trial designed to assess the effect of the MD enriched with extra virgin olive oil (EVOO) on the prevention of depression recurrence. The intervention group received usual care for depressed patients and remote nutritional intervention every three months which included phone contacts and webbased interventions; and the control group, usual care. At baseline and at 1-year and 2-year follow-up, the 14-item MD Adherence Screener (MEDAS) questionnaire and a semiquantitative food frequency questionnaire (FFQ) were collected by a dietitian. Mixed effects linear models were used to assess changes in nutritional variables according to the group of intervention. The trial was registered at ClinicalTrials.gov NCT03081065. Results: Compared with control group, the MD intervention group showed more adherence to MD (between-group difference: 2.76; 95% CI 2.13–3.39; p < 0.001); and a healthier diet pattern with a significant increase in the consumption of olive oil (p < 0.001), and a significant reduction in refined cereals (p = 0.031) after 2 years of intervention. Conclusions: The remote nutritional intervention increases adherence to the MD among recovered depression patients. Trial registration: ClinicalTrials.gov identifier: NCT03081065.Publication Open Access Sedentary behaviors and risk of depression in the Seguimiento Universidad de Navarra cohort: the SUN Project(Escola Nacional de Saude Pública Sergio Arouca, 2022) Pimenta, Adriano Marçal; Deus Mendonça, Raquel de; Lahortiga Ramos, Francisca; Fernández-Lázaro, César; Martínez González, Miguel Ángel; Sánchez Villegas, María Almudena; Ciencias de la Salud; Osasun Zientziak; Gobierno de Navarra / Nafarroako GobernuaThe study aimed to prospectively examine the association between different sedentary behaviors and the risk of depression. We included 12,691 Spanish university graduates (mean age: 36.7 year; SD: 11.5), participants of the Seguimiento Universidad de Navarra cohort (the SUN Project), initially free of depression who were followed-up for a median of 10.9 years. Based on items presented in our baseline questionnaire, time spent in four sedentary behaviors (hours/day) were evaluated: overall sitting time; TV-viewing; computer use; and driving. Participants were classified as incident cases of depression if they reported a physician diagnosis of depression in at least one of the follow-up assessments conducted after the first two years of follow-up. Cox regression models were used to assess the relationship between sedentary behaviors and depression. A total of 560 incident cases of depression were identified during follow-up. We found no significant association between overall sitting time, TV-viewing or driving and risk of depression. On the other hand, computer use was directly associated with the risk of developing depression during the follow-up (p-value for trend = 0.020), with the participants in the highest quartile of computer use (3.64 to 10 hours/week) having a higher risk of developing depression (HR = 1.33; 95%CI: 1.05-1.70) than those in the lowest quartile (0 to 0.25 hours/week) after adjusting for potential confounders. Prolonged use of computer was independently associated with an increased risk of developing depression among young middle-aged adult university graduates from a Spanish cohort.Publication Open Access Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study(Public Library of Science, 2022) Martín Peláez, Sandra; Serra-Majem, Lluis; Cano Ibáñez, Noemí; Martínez González, Miguel Ángel; Salas-Salvadó, Jordi; Corella, Dolores; Lassale, Camille; Martínez, Jose Alfredo; Alonso Gómez, Ángel M.; Wärnberg, Julia; Vioque, Jesús; Romaguera, Dora; López Miranda, José; Estruch, Ramón; Tinahones, Francisco J.; Lapetra, José; Fernández-Aranda, Fernando; Bueno Cavanillas, Aurora; Tur, Josep A.; Martín, Vicente; Pintó, Xavier; Delgado Rodríguez, Miguel; Matía, Pilar; Vidal, Josep; Vázquez, Clotilde; Daimiel, Lidia; Ros, Emilio; Toledo, Estefanía; Nishi, Stephanie K.; Sorli, Jose V.; Malcampo, Mireia; Zulet, María Ángeles; Moreno Rodríguez, Anaí; Cueto Galán, Raquel; Vivancos Aparicio, Diego; Colom, Antoni; García-Rios, Antonio; Casas, Rosa; Bernal López, M. Rosa; Santos Lozano, José Manuel; Vázquez, Zenaida; Gómez-Martínez, Carlos; Ortega Azorín, Carolina; Val, José Luis del; Abete, Itziar; Goikoetxea Bahon, Amaia; Pascual, Elena; Becerra-Tomás, Nerea; Chillarón, Juan J.; Sánchez Villegas, María Almudena; Institute on Innovation and Sustainable Development in Food Chain - ISFOODBackground Cardio-vascular disease and depression are thought to be closely related, due to shared risk factors. The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and depressive status in a population (55-75 years) with metabolic syndrome (MetS) from the PREDIMED-Plus trial. Methods and findings Participants were classified into three groups of CVR according to the Framingham-based REGICOR function: (1) low (LR), (2) medium (MR) or (3) high/very high (HR). The Beck Depression Inventory-II (BDI-II) was used to assess depressive symptoms at baseline and after 2 years. The association between CVR and depressive status at baseline (n = 6545), and their changes after 2 years (n = 4566) were evaluated through multivariable regression models (logistic and linear models). HR women showed higher odds of depressive status than LR [OR (95% CI) = 1.78 (1.26, 2.50)]. MR and HR participants with total cholesterol <160 mg/mL showed higher odds of depression than LR [OR (95% CI) = 1.77 (1.13, 2.77) and 2.83 (1.25, 6.42) respectively)] but those with total cholesterol ¿280 mg/mL showed lower odds of depression than LR [OR (95% CI) = 0.26 (0.07, 0.98) and 0.23 (0.05, 0.95), respectively]. All participants decreased their BDI-II score after 2 years, being the decrease smaller in MR and HR diabetic compared to LR [adjusted mean±SE = -0.52±0.20, -0.41 ±0.27 and -1.25±0.31 respectively). MR and HR participants with total cholesterol between 240-279 mg/mL showed greater decreases in the BDI-II score compared to LR (adjusted mean±SE = -0.83±0.37, -0.77±0.64 and 0.97±0.52 respectively). Conclusions Improving cardiovascular health could prevent the onset of depression in the elderly. Diabetes and total cholesterol in individuals at high CVR, may play a specific role in the precise response.