Person:
Pérez Prados, Antonio

Profile Picture

Email Address

person.page.identifierURI

https://academica-e.unavarra.es/handle/2454/49783

Birth Date

Research Projects

Organizational Units

Job Title

Last Name

Pérez Prados

First Name

Antonio

person.page.departamento

Estadística, Informática y Matemáticas

person.page.instituteName

ORCID

0000-0002-6496-4242

person.page.upna

34

Name

Filters

20131
Reset filters

Settings

Subject: Human papillomavirus (HPV) × Subject: Cervical samples ×

Search Results

Now showing 1 - 1 of 1
  • Thumbnail Image
    PublicationOpen Access
    Human papillomavirus detection from human immunodeficiency virus-infected Colombian women’s paired urine and cervical samples
    (Public Library of Science, 2013) Muñoz Bobo, Marina; Camargo, Milena; Soto de León, Sara; Sánchez, Ricardo; Parra, Diana; Pineda Peña, Andrea; Sussmann, Otto; Pérez Prados, Antonio; Patarroyo, Manuel Elkin; Patarroyo, Manuel Alfonso; Estadística e Investigación Operativa; Estatistika eta Ikerketa Operatiboa
    Infection, coinfection and type-specific human papillomavirus (HPV) distribution was evaluated in human immunodeficiency virus (HIV)-positive women from paired cervical and urine samples. Paired cervical and urine samples (n = 204) were taken from HIV-positive women for identifying HPV-DNA presence by using polymerase chain reaction (PCR) with three generic primer sets (GP5+/6+, MY09/11 and pU1M/2R). HPV-positive samples were typed for six high-risk HPV (HR-HPV) (HPV-16, -18, -31, -33, -45 and -58) and two low-risk (LR-HPV) (HPV-6/11) types. Agreement between paired sample results and diagnostic performance was evaluated. HPV infection prevalence was 70.6% in cervical and 63.2% in urine samples. HPV-16 was the most prevalent HPV type in both types of sample (66.7% in cervical samples and 62.0% in urine) followed by HPV-31(47.2%) in cervical samples and HPV-58 (35.7%) in urine samples. There was 55.4% coinfection (infection by more than one type of HPV) in cervical samples and 40.2% in urine samples. Abnormal Papanicolau smears were observed in 25.3% of the women, presenting significant association with HPV-DNA being identified in urine samples. There was poor agreement of cervical and urine sample results in generic and type-specific detection of HPV. Urine samples provided the best diagnosis when taking cytological findings as reference. In conclusion including urine samples could be a good strategy for ensuring adherence to screening programs aimed at reducing the impact of cervical cancer, since this sample is easy to obtain and showed good diagnostic performance.