Rivera, Diego
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Rivera
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Diego
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Ciencias de la Salud
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Publication Open Access Cognitive and brain connectivity trajectories in critically ill COVID-19 patients(IOS Press, 2024) Ramos Usuga, Daniela; Jiménez-Marín, Antonio; Cabrera-Zubizarreta, Alberto; Benito Sánchez, Itziar; Rivera, Diego; Martínez-Gutiérrez, Endika; Panera, Elena; Boado, Victoria ; Labayen, Fermín; Cortés, Jesús M.; Arango Lasprilla, Juan Carlos; Ciencias de la Salud; Osasun ZientziakBACKGROUND: Multiple Organ failure (MOF) is one of the main causes of admission to the Intensive Care Unit (ICU) of patients infected with COVID-19 and can cause short- and long-term neurological deficits. OBJECTIVE: To compare the cognitive functioning and functional brain connectivity at 6-12 months after discharge in two groups of individuals with MOF, one due to COVID-19 and the other due to another cause (MOF-group), with a group of Healthy Controls (HC). METHODS: Thirty-six participants, 12 from each group, underwent a neuropsychological and neuroimaging assessment at both time-points. Functional connectivity of the resting state networks was compared between COVID-19 and HC while controlling for the effect of MOF. The association between functional connectivity and neuropsychological performance was also investigated. RESULTS: Compared to the HC, COVID-19 group demonstrated hypoconnectivity between the Default Mode Network and Salience Network. This pattern was associated with worse performance on tests of attention and information processing speed, at both time-points. CONCLUSION: The study of the association between cognitive function and brain functional connectivity in COVID-19 allows the understanding of the short- and long-term neurological alterations of this disease and promotes the development of intervention programs to improve the quality of life for this understudied population.Publication Open Access Multivariate base rates of low scores on tests of learning and memory among Spanish speaking children(Taylor & Francis, 2020) Benito Sánchez, Itziar; Ertl, Melissa M.; Ferrer Cascales, Rosario; Oltra Cucarella, Javier; Ibáñez Alfonso, Joaquín A.; Saracostti Schwartzman, Mahia; Soto Añari, Marcio; Cadavid Ruiz, Natalia; Rodríguez Lorenzana, Alberto; Rivera, Diego; Arango Lasprilla, Juan Carlos; Ciencias de la Salud; Osasun ZientziakTo determine the prevalence of low scores on two neuropsychological tests commonly used to evaluate learning and memory in children. 6,030 healthy children from 10 countries in Latin America and Spain were administered Rey–Osterrieth Complex Figure (ROCF) and the Test de Aprendizaje y Memoria Verbal–Infantil (TAMV-I). Results showed that low scores are common when multiple neuropsychological outcomes (tests and/or scores) are evaluated in healthy individuals. Clinicians should consider the higher probability of low scores in a given individual when evaluating learning and memory using various sets of scores to reduce false-positive diagnoses of cognitive deficits in pediatric populations.