Embargo
Test of memory malingering 2nd edition: normative data from cognitively intact adults living in Spain
(Routledge, 2024-11-05) Arango Lasprilla, Juan Carlos; Ayearst, Lindsay E.; Rivera, Diego; Dini, Mia E.; Olabarrieta Landa, Laiene; Ramos Usuga, Daniela; Perrin, Paul B.; McCaffrey, Robert; Ciencias de la Salud; Osasun Zientziak
This study evaluated the universality of the TOMM 2 and provided a reference sample of cognitively intact adults living in Spain whose native language was Spanish. A total of 203 adults completed the TOMM 2 from June 2019 to January 2020. When using the original TOMM cutoff scores derived from English speakers, all participants scored in a range that would suggest that they passed the TOMM. When using a cut score less than 40 on Trial 1, only one participant in this study would be mistakenly classified as providing an invalid performance. Spanish-speaking adults in Spain from this study achieved a perfect score on Trial 1 at a rate more than double that of English-speaking individuals on the original TOMM. At the item level, all but one item met the minimum standard for performance validity; this item fell only marginally below the standard at 89%. This study found a very low failure rate for the TOMM 2, suggesting that the second edition has at least as high specificity as the original in Spanish adults.
Open Access
Normative data for tests of visuo-spatial, visuo-constructional skills, and visual memory for Spanish-speaking adults in the United States
(SAGE, 2024-09-17) Morel Valdés, Gloria M.; Rivera, Diego; Olabarrieta Landa, Laiene; Carrión, Carmen I.; Lequerica, Anthony H.; Maltez, Fatima Iyarit; Rodríguez, Miriam J.; Dini, Mia E.; Munoz, Geovani; Ramos Usuga, Daniela; Drago, Christin I.; García, Patricia; Rivera, Patricia M.; Perrin, Paul B.; Arango Lasprilla, Juan Carlos; Ciencias de la Salud; Osasun Zientziak
Background: The Rey-Osterrieth Complex Figure Test (ROCFT) and the Clock Drawing Test (CDT) are commonly used in clinical practice. The ROCFT measures constructional praxis, visual perception, and visuospatial learning and memory and the CDT assesses for visuospatial, constructional, and executive difficulties. Several neurological disorders are associated with visuospatial and visuoconstructional impairments, yet reliable normative data accounting for sociodemographic aspects of identity and acculturative variables are scarce for Hispanics living in the U.S. Objective: To generate normative data for the ROCF and CDT in a Spanish-speaking adult population living in the U.S. Methods: The sample consisted of 245 participants' cognitively normal adults, recruited from several states in the U.S. Each participant was administered the ROCFT and CDT as part of a larger cognitive battery. The ROCFT and CDT were normed using a Bayesian approach. Age, age, education, sex, acculturation, and language competence, were included as predictors in the analyses. Results: ROCFT was associated with education and age, particularly as they interact with Spanish language competency, and time spent in the U.S. Education was significantly associated with recall abilities and a lower memory recall on the ROCFT. Age was found to vary depending on a person¿s bilingual abilities. Sex did not emerge as a predictor of performance, and it was not moderated by other variables. Conclusions: This is the first study to include acculturation and language proficiency variables in the creation of norms for the assessment of visuoconstruction abilities. This study will have a large impact on the practice of neuropsychology in the U.S.
Open Access
Normative data of neuropsychological tests of attention and executive functions in Ecuadorian adult population
(Routledge, 2021) Rodríguez Lorenzana, Alberto; Ramos Usuga, Daniela; Adana Díaz, Lila; Mascialino, Guido; Rivera, Diego; Ciencias de la Salud; Osasun Zientziak
Objective: The purpose of this study was to generate normative data for five tests of attention and executive functions (M-WCST, Stroop test, TMT, BTA, and SDMT), in a group of 322 Ecuadorian adults from Quito between the ages of 18 and 85. Method: Multiple regression analyzes taking into account age, education, and gender were used to generate the normative data. Results: Age and education were significantly related to test performance such that scores decreased with age and improved as a function of education. An online calculator is provided to generate normative test scores. Conclusions: This is the first study that presents normative data for tests of executive functions and attention in an Ecuadorian adult population. This data will improve the clinical practice of neuropsychology and help to develop the field in the country.
Open Access
Validation of the Norma Latina neuropsychological assessment battery in individuals with multiple sclerosis in Mexico
(Elsevier, 2022) Rivera, Diego; Ramos Usuga, Daniela; Fuentes Mendoza, Eliana María; Aguayo Arelis, Adriana; Rabago Barajas, Brenda Viridiana; Macías Islas, Miguel Ángel; Krch, Denise; Lequerica, Anthony H.; Arango Lasprilla, Juan Carlos; Ciencias de la Salud; Osasun Zientziak
Background. Between 50-60% of Multiple Sclerosis (MS) patients have cognitive alterations. There are several batteries to assess cognitive impairments in MS, however, few exist for Latin Americans. The objective of this study is to evaluate the neuropsychological profile of Mexican people with MS (PwMS) and assess the utility of Norma Latina, a new battery for cognitive assessment in Latin America, in differentiating cognitive test performance between PwMS and healthy controls (HC). Methods. 100 PwMS and 100 HC from Mexico were evaluated with the Norma Latina battery. The following analyses were conducted: 1) low-percentiles of each participant were calculated, 2) Area Under the Curve was used to determine whether the battery discriminated between PwMS and HC, 3) four composite scores were calculated, and student’s t-test was used to compare groups according to these domains. Results. PwMS obtained a greater number of impaired scores compared to HCs, principally in executive function. The battery successfully discriminated between PwMS and HCs, with the strongest capacity to discriminate in the executive functions, and the weakest in memory. Conclusion. Establishing validation of a neuropsychological battery for Mexican PwMS will help to more accurately detect cognitive alterations, which will guide the decisions of professionals in terms of cognitive rehabilitation.
Open Access
A preliminary examination of the TOMM2 in a sample of Spanish speakers in the United States
(SAGE, 2024-09-02) Ramos Usuga, Daniela; Ayearst, Lindsay E.; Rivera, Diego; Krch, Denise; Perrin, Paul B.; Carrión, Carmen I.; Morel Valdés, Gloria M.; Loro, Delly; Rodríguez, Miriam J.; Munoz, Geovani; Drago, Christin I.; García, Patricia; Rivera, Patricia M.; Arango Lasprilla, Juan Carlos; Ciencias de la Salud; Osasun Zientziak
BACKGROUND: The Test of Memory Malingering (TOMM) is a widely used performance validity measure that is available in both English and Spanish. The Spanish version, however, has historically lacked normative data from samples that are representative of the U.S. Hispanic/Spanish speaking population. OBJECTIVE: The aim of the current study was to collect normative data on the update TOMM 2 for Hispanic individuals residing in the U.S. METHODS: Normative data on the TOMM 2 was collected across 9 sites from different regions of the U.S. The total sample consisted of n=188 cognitively healthy adults aged 18 and over with no current or prior history of neurological or psychiatric disorder. Descriptive analyses were performed on total raw scores. RESULTS: Participants obtained a mean score of 48.15 (SD=2.81) on trial 1 of the TOMM 2, 49.86 (SD=0.487) on trial 2, and 49.84 (SD=0.509) on the recognition trial. Scores are provided for traditional cutoff scores as well as some popular cutoffs reported in the literature. Item level analyses were conducted as well as evaluation of performance based on a variety of demographics. CONCLUSION: When compared to the English-speaking normative sample used for the original TOMM, this sample demonstrated better performance on the TOMM 2 indicating better cultural appropriateness of the items. This is the first study conducted that provides culturally appropriate descriptive norms for use with Spanish speakers living in the U.S.
Open Access
Normative data study of verbal fluency and naming tests in elderly people in Costa Rica
(Oxford University Press, 2024) Mora-Villalobos, Lara; Brown-Mata, Gloriana; Smith-Castro, Vanessa; Ramos Usuga, Daniela; Rivera, Diego; Arango Lasprilla, Juan Carlos; Ciencias de la Salud; Osasun Zientziak
Objective: to generate normative data for the Verbal Fluency Test (VFT) and the Boston Naming Test (BNT) in the Costa Rican population. Method The sample consisted of 563 healthy older people (aged 59-90 years). Polynomial multiple regression analyses were run to evaluate the effects of the age, sex, and education variables on VFT and BNT scores.Results The results showed a significant linear effect of education on the four-letter VF scores and an effect of sex on the letter P score, with females performing better than males. The explained variance ranged from 20.9% to 28.3%. A linear effect of age and education was also found for the four semantic VF scores, with scores decreasing with increasing age and lower education. The sex variable was significant for all semantic categories, with females performing better than males except in the animal category. The explained variance ranged from 21.7% to 30.9%. In the BNT, a linear effect of education was found, so that the more education, the better the score. In addition, a sex effect was also found, with males having higher scores than females. The predictors of the model explained 9.6% of the variance. Conclusions: this is the first study that generates normative data for the VF and BNT in the Costa Rican population over 59 years of age based on demographic variables. The use of these normative data will help clinicians in Costa Rica to better understand language functioning in the elderly, allowing for better classification and diagnosis in the future.
Open Access
Executive function tests: normative data for Spanish-speaking adults in the United States
(2024-09-02) Ramos Usuga, Daniela; Rivera, Diego; Xia, Bridget; Carrión, Carmen I.; Morel Valdés, Gloria M.; Moreno, Oswaldo; Rodríguez, Miriam J.; Krch, Denise; Wongserbchart, Wongthipa; Drago, Christin I.; García, Patricia; Rivera, Patricia M.; Olabarrieta Landa, Laiene; Perrin, Paul B.; Arango Lasprilla, Juan Carlos; Ciencias de la Salud; Osasun Zientziak
Background: normative data for Spanish-speaking populations, particularly Hispanics in the U.S., is notably scarce. Objective: This study aims to establish normative data for executive function tests (M-WCST, SCWT) among Spanish-speaking Hispanics in the U.S. Methods: we assessed 245 individuals aged 18-80 from eight U.S. states (California, Connecticut, Florida, Indiana, New Jersey, Oregon, Virginia, and Wisconsin) and employed Bayesian regression to estimate norms, considering various sociodemographic factors influencing performance. Results: age impacts SCWT scores negatively, especially in older individuals, with stronger effects among those proficient in Spanish. Age also affects M-WCST performance more in individuals with longer U.S. residency. Education correlates with M-WCST outcomes, with lower attainment linked to more errors. Education interacts with Spanish proficiency, influencing SCWT scores differently based on proficiency levels. Sex and acculturation levels interact, affecting SCWT performance differently between men and women. Conclusions: establishing culturally sensitive normative data can enhance accurate identification of executive dysfunction and reduce misdiagnosis risks. This underscores the importance of considering sociocultural factors including acculturation and language proficiency in neuropsychological assessments to better serve diverse populations.
Open Access
Cognitive and brain connectivity trajectories in critically ill COVID-19 patients
(IOS Press, 2024) Ramos Usuga, Daniela; Jiménez-Marín, Antonio; Cabrera-Zubizarreta, Alberto; Benito Sánchez, Itziar; Rivera, Diego; Martínez-Gutiérrez, Endika; Panera, Elena; Boado, Victoria ; Labayen, Fermín; Cortés, Jesús M.; Arango Lasprilla, Juan Carlos; Ciencias de la Salud; Osasun Zientziak
BACKGROUND: Multiple Organ failure (MOF) is one of the main causes of admission to the Intensive Care Unit (ICU) of patients infected with COVID-19 and can cause short- and long-term neurological deficits. OBJECTIVE: To compare the cognitive functioning and functional brain connectivity at 6-12 months after discharge in two groups of individuals with MOF, one due to COVID-19 and the other due to another cause (MOF-group), with a group of Healthy Controls (HC). METHODS: Thirty-six participants, 12 from each group, underwent a neuropsychological and neuroimaging assessment at both time-points. Functional connectivity of the resting state networks was compared between COVID-19 and HC while controlling for the effect of MOF. The association between functional connectivity and neuropsychological performance was also investigated. RESULTS: Compared to the HC, COVID-19 group demonstrated hypoconnectivity between the Default Mode Network and Salience Network. This pattern was associated with worse performance on tests of attention and information processing speed, at both time-points. CONCLUSION: The study of the association between cognitive function and brain functional connectivity in COVID-19 allows the understanding of the short- and long-term neurological alterations of this disease and promotes the development of intervention programs to improve the quality of life for this understudied population.
Open Access
Normative data for verbal fluency and naming tests in Spanish-speaking adults in the United States
(SAGE, 2024-08-22) Olabarrieta Landa, Laiene; Rivera, Diego; Xia, Bridget; Moreno, Oswaldo; Ramos Usuga, Daniela; Morel Valdés, Gloria M.; López, Enrique; Rodríguez, Miriam J.; Carrión, Carmen I.; Lequerica, Anthony H.; Drago, Christin I.; García, Patricia; Rivera, Patricia M.; Perrin, Paul B.; Arango Lasprilla, Juan Carlos; Ciencias de la Salud; Osasun Zientziak
Background: The Rey-Osterrieth Complex Figure Test (ROCFT) and the Clock Drawing Test (CDT) are commonly used in clinical practice. The ROCFT measures constructional praxis, visual perception, and visuospatial learning and memory and the CDT assesses for visuospatial, constructional, and executive difficulties. Several neurological disorders are associated with visuospatial and visuoconstructional impairments, yet reliable normative data accounting for sociodemographic aspects of identity and acculturative variables are scarce for Hispanics living in the U.S. Objective: To generate normative data for the ROCF and CDT in a Spanish-speaking adult population living in the U.S. Methods: The sample consisted of 245 participants¿ cognitively normal adults, recruited from several states in the U.S. Each participant was administered the ROCFT and CDT as part of a larger cognitive battery. The ROCFT and CDT were normed using a Bayesian approach. Age, age2, education, sex, acculturation, and language competence, were included as predictors in the analyses. Results: ROCFT was associated with education and age, particularly as they interact with Spanish language competency, and time spent in the U.S. Education was significantly associated with recall abilities and a lower memory recall on the ROCFT. Age was found to vary depending on a person¿s bilingual abilities. Sex did not emerge as a predictor of performance, and it was not moderated by other variables. Conclusions: This is the first study to include acculturation and language proficiency variables in the creation of norms for the assessment of visuoconstruction abilities. This study will have a large impact on the practice of neuropsychology in the U.S.
Open Access
Attention and processing speed tests: normative data for Spanish-speaking adults in the United States
(SAGE, 2024-09-26) Carrión, Carmen I.; Rivera, Diego; Forte, Anabel; Olabarrieta Landa, Laiene; Moreno, Oswaldo; Ramos Usuga, Daniela; Morel Valdés, Gloria M.; López, Melisa; Rodríguez, Miriam J.; Lequerica, Anthony H.; Drago, Christin I.; García, Patricia; Rivera, Patricia M.; Perrin, Paul B.; Arango Lasprilla, Juan Carlos; Ciencias de la Salud; Osasun Zientziak
Background: Hispanics/Latinos are the largest Spanish-speaking subgroup in the U.S. and multiple sociodemographic, cultural, and linguistic factors have been found to impact their performances on cognitive testing. Despite this, few normative data are available for the heterogeneous Spanish-speaking population in the U.S. Objective: to generate normative data on the TMT, Bells Test, SDMT, and the BTA for Spanish speakers residing in the U.S. Methods: the sample included 245 Spanish speaking individuals aged 18-80 from eight states across the U.S. (California, Connecticut, Florida, Indiana, New Jersey, Oregon, Virginia, and Wisconsin). Participants were administered attention and processing speed measures as part of a comprehensive neuropsychological battery. We used a Bayesian regression approach to estimate normative data, including covariates found to be important for predicting performances on measures of attention and processing speed. Results: sociodemographic factors including education, time in the U.S., acculturation, age, and/or sex had differential effects on the TMT-A, TMT-B, SDMT, and the BTA whereas the Bells Test was not influenced by any of these sociodemographic factors. Conclusions: our findings indicate that while sex, age, and educational attainment are important factors to consider, language and acculturation can also influence attention and processing speed performances among Spanish speakers in the U.S.