García Castillo, Jesús María

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https://academica-e.unavarra.es/handle/2454/49075

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García Castillo

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Jesús María

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Ciencias

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InaMat2. Instituto de Investigación en Materiales Avanzados y Matemáticas

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0000-0001-6632-097X

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88464

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573

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Author: Campano, Teresa E. × Subject: Michael reaction ×

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    PublicationOpen Access
    Enantioselective addition of alkynyl ketones to nitroolefins assisted by Brønsted base/H-bonding catalysis
    (Wiley, 2019) Campano, Teresa E.; Iriarte, Igor; Olaizola, Olatz; Etxabe, Julen; Mielgo, Antonia; Ganboa, Iñaki; Odriozola Ibarguren, José Manuel; García Castillo, Jesús María; Oiarbide, Mikel; Palomo, Claudio; Zientziak; Institute for Advanced Materials and Mathematics - INAMAT2; Ciencias
    Various sets of enolizable alkynyl ketones (including methyl ynones with α-aryl, α-alkenyl, and α-alkoxy groups) were able to react smoothly with nitroolefins with the assistance of bifunctional Brønsted base/H-bond catalysts to provide adducts with two consecutive tertiary stereocenters in a highly diastereo- and enantioselective fashion. Further transformation of the obtained adducts into optically active acyclic and polycyclic molecules, including some with intricate carbon skeletons, was also demonstrated.