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Guillén Grima, Francisco

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https://academica-e.unavarra.es/handle/2454/49219

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Guillén Grima

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Francisco

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Ciencias de la Salud

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0000-0001-9749-8076

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352

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2015 - 20198
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Start date: 2010 × End date: 2019 × Author: Niu, Hao ×

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Now showing 1 - 8 of 8
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    PublicationOpen Access
    Prevalence and incidence of Alzheimer's disease in Europe: a meta-analysis
    (Elsevier España, 2017) Niu, Hao; Álvarez Álvarez, Ismael; Guillén Grima, Francisco; Aguinaga Ontoso, Inés; Ciencias de la Salud; Osasun Zientziak
    Background: A disease of unknown aetiology, Alzheimer’s disease (AD) is the most common type of dementia. As the elderly population grows worldwide, the number of patients with AD also increases rapidly. The aim of this meta-analysis is to evaluate the prevalence and incidence of AD in Europe. Methodology: We conducted a literature search on Medline, Scopus, and CINAHL Complete using the keywords ‘‘Alzheimer’’, ‘‘Alzheimer’s disease’’, and ‘‘AD’’ combined with ‘‘prevalence’’, ‘‘incidence’’, and ‘‘epidemiology’’. A Bayesian random effects model with 95% credible intervals was used. The I 2 statistic was applied to assess heterogeneity. Results: The prevalence of Alzheimer’s disease in Europe was estimated at 5.05% (95% CI, 4.73-5.39). The prevalence in men was 3.31% (95% CI, 2.85-3.80) and in women, 7.13% (95% CI, 6.56-7.72), and increased with age. The incidence of Alzheimer’s disease in Europe was 11.08 per 1000 person-years (95% CI, 10.30-11.89). Broken down by sex, it was 7.02 per 1000 person-years (95% CI, 6.06-8.05) in men and 13.25 per 1000 person-years (95% CI, 12.05-14.51) in women; again these rates increased with age. Conclusions: The results of our meta-analysis allow a better grasp of the impact of this disease in Europe.
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    PublicationOpen Access
    Prevalence and risk factors for wheezing in infants in the region of Pamplona, Spain
    (Elsevier, 2016) Álvarez Álvarez, Ismael; Niu, Hao; Aguinaga Ontoso, Inés; Guillén Grima, Francisco; Ciencias de la Salud; Osasun Zientziak; Gobierno de Navarra / Nafarroako Gobernua: 6106
    Background: Wheezing in the first year of life affects life’s quality of the baby and the family. Risk factors such as male gender, nursery attending or a family history of asthma, and protective factors such as breastfeeding more than 6 months have been previously described. The aim of this study is to study the prevalence and risk factors for wheezing ever and recurrent wheezing in the first year of life in infants in the region of Pamplona, Spain. Material and methods: This cross-sectional study was part of the International Study of Wheezing in Infants (Estudio Internacional de Sibilancias en Lactantes, EISL). Between 2006 and 2008, participating families answered a standardized validated questionnaire on respiratory symptoms, environmental factors or family issues. An analysis with the chi square test (statistical significance p<0.05) identified the risk factors for wheezing ever and recurrent wheezing, which were assessed using logistic regression. Results: 1065 questionnaires were answered. The prevalence of wheezing ever and recurrent wheezing were 31.2% and 12.3%, respectively. Male gender (p=<0.001), a history of pneumonia (p=<0.001) or nursery attendance (p=<0.001) were some of the risk factors found for wheezing ever. Infant eczema (p=<0.001), nursery attendance (p=<0.001) or prematurity (p=<0.001) were risk factors for recurrent wheezing. No associations with duration of breastfeeding (p=0.116 and p=0.851) or mould stains at home (p=0.153 and p=0.992) were found. Conclusion: The study of prevalence and risk factors for wheezing shows the importance of this public health problem, and allows the development of control and treatment strategies against preventable factors.
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    PublicationOpen Access
    Infant mortality in the European Union: a time trend analysis of the 1994-2015 period
    (Elsevier España, 2019) Onambele, Luc; San Martín Rodríguez, Leticia; Niu, Hao; Álvarez Álvarez, Ismael; Arnedo Pena, Alberto; Guillén Grima, Francisco; Aguinaga Ontoso, Inés; Ciencias de la Salud; Osasun Zientziak
    Introducción: La mortalidad infantil es un indicador de la salud infantil y una variable explicativa del desarrollo socioeconómico. Nuestro objetivo fue examinar los cambios y tendencias de la mortalidad infantil en la Unión Europea (UE) y sus 28 países miembros en el período 1994-2015. Métodos: Se recopilaron datos de muertes de niños menores de un año entre 1994 y 2015 de la base de datos Eurostat. Estudiamos las tendencias en la UE, por países y regiones, utilizando elanálisis de regresión joinpoint. Se condujeron análisis adicionales para estudiar las tendencias de mortalidad neonatal y neonatal precoz. Resultados: La mortalidad infantil en la UE ha disminuido significativamente de 8.3 a 3.6 por 1.000 (porcentaje de cambio anual = −3.8%, intervalos de confianza del 95% −4.1; −3.6). Las tasas de mortalidad más altas se registraron en Rumanía y Bulgaria, y las tasas más bajas en países escandinavos (Finlandia, Suecia). Se encontraron tendencias descendentes significativas en los países de la UE, más pronunciadas en los países bálticos exsoviéticos y países de Europa oriental, mientras que los países de Europa occidental mostraron los descensos menos pronunciados. La mortalidad infantil ha aumentado significativamente en Grecia en los últimos años,mientras que en el Reino Unido e Irlanda las tasas se han estabilizado. Conclusiones: La mortalidad infantil ha disminuido en la UE y sus países en las últimas décadas, más pronunciadamente en los países de Europa oriental y los países bálticos exsoviéticos, mientras que en varios países de Europa occidental las tasas aumentaron o se han estabilizado enlos últimos años.
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    PublicationOpen Access
    Prevalencia e incidencia de la enfermedad de Alzheimer en Europa: metaanálisis
    (Elsevier España, 2017) Niu, Hao; Álvarez Álvarez, Ismael; Guillén Grima, Francisco; Aguinaga Ontoso, Inés; Ciencias de la Salud; Osasun Zientziak
    Introducción: La enfermedad de Alzheimer es el principal tipo de demencia, y una enfermedad de etiología desconocida. Con el aumento de la población anciana mundial, el número de pacientes con enfermedad de Alzheimer muestra una tendencia de crecimiento rápido. El objetivo de este metaanálisis es evaluar la prevalencia e incidencia de la enfermedad de Alzheimer en Europa. Metodología: La búsqueda de artículos se realizó en las bases de datos Medline, Scopus y CINAHL Complete utilizando las palabras claves “Alzheimer”, “Alzheimer’s disease” y “AD”; combinadas con “prevalence”, “incidence” y “epidemiology”. Se utilizó el modelo Bayesiano de efectos aleatorios, mostrando intervalos de credibilidad al 95%. Para estimar la heterogeneidad se usó el estadístico I2. Resultados: La prevalencia de enfermedad de Alzheimer en Europa fue 5,05% (IC 95% 4,73-5,39). La prevalencia por sexo en los hombres y las mujeres fue 3,31% (IC 95% 2,85-3,80) y 7,13% (IC 95% 6,56-7,72), respectivamente, y se encontró una tendencia creciente por grupos de edad. La incidencia de enfermedad de Alzheimer en Europa fue 11,08 por 1000 personas-año (IC 95% 10,30-11,89), siendo en los hombres y las mujeres de 7,02 por 1000 personas-año (IC 95% 6,06-8,05) y 13,25 por 1000 personas-año (IC 95% 12,05-14,51), respectivamente, con igual tendencia creciente con el aumento de la edad. Conclusiones: Los resultados del metaanálisis permiten una mejor comprensión de la enfermedad y su impacto en Europa.
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    PublicationOpen Access
    Estudio transversal de los factores que influyen en la adhesión a la dieta mediterránea en el embarazo
    (Arán Ediciones, 2015) Álvarez Álvarez, Ismael; Aguinaga Ontoso, Inés; Marín Fernández, Blanca; Guillén Grima, Francisco; Niu, Hao; Ciencias de la Salud; Osasun Zientziak
    Introducción: La dieta mediterránea es un estilo de vida con efectos beneficiosos contrastados en el embarazo, tanto para la madre como para su descendencia. Sin embargo, se desconocen los factores que influyen en la adhesión a esta dieta. Objetivo: Investigar los factores (nivel educativo, ocupación, lugar de nacimiento, número de hijos previo y edad) que influyen en la adhesión a la dieta mediterránea en mujeres embarazadas de la comarca de Pamplona. Material y métodos: Utilizando los datos del Estudio Internacional de Sibilancias en Lactantes (EISL) en la comarca de Pamplona, se analizaron las asociaciones entre los alimentos y los factores. Se estableció una puntuación de dieta mediterránea y se estudiaron las puntuaciones de acuerdo a los factores. Resultados: Se encontraron diferencias significativas en la puntuación de dieta mediterránea según el nivel de estudios (p=<0,001), la ocupación (p=0,015) y la edad (p=<0,001). Conclusión: Mujeres con mejor nivel educativo, mejor ocupación y mayor edad muestran una mayor afinidad a la dieta mediterránea durante el embarazo.
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    PublicationOpen Access
    Meta-analysis of prevalence of wheezing and recurrent wheezing in infants
    (Elsevier, 2016) Álvarez Álvarez, Ismael; Niu, Hao; Guillén Grima, Francisco; Aguinaga Ontoso, Inés; Ciencias de la Salud; Osasun Zientziak
    Background: Wheezing affects children’s quality of life, and is related with asthma in childhood. Although prevalence of wheezing has been previously studied in several countries, there are no reference of worldwide prevalence in infants. The aim of this meta-analysis is to estimate the prevalence of wheezing and recurrent wheezing in infants aged up to two years, and compare the prevalence across world regions. Methods: Literature search was conducted in MEDLINE and SCOPUS databases, looking for observational studies published up to June 2016, including as keywords “prevalence” or “epidemiology” combined with “wheeze”, “wheezing” or “asthma symptoms” and “infant” or “preschool”. Fast*Pro software and random effects Bayesian model were used. Heterogeneity was estimated using I2 statistic, and sensitivity analyses were performed. Results: We identified 109 studies after duplicates were removed. After exclusions, 14 studies were included in the meta-analysis. Prevalence of wheezing and recurrent wheezing were 36.06% (95% CI 35.17-36.96), and 17.41% (95% CI 16.74-18.09), respectively. In European countries, prevalence of wheezing was 30.68% (95% CI 28.97-32.45), and 12.35% (95% CI 11.27-13.47) for recurrent wheezing. Prevalence of wheezing and recurrent wheezing in Latin America were higher, 40.55% (95% CI 39.40-41.71), and 19.27% (95% CI 18.44-20.11), respectively. In Africa, prevalence of wheezing was 15.97% (95% CI 14.05-18.00). Low or no heterogeneity was found in all cases. Conclusions: More than one third of infants suffer from wheezing and almost one fifth from recurrent wheezing, being these illnesses especially prevalent in Latin American countries, pointing out an important public health problem.
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    PublicationOpen Access
    Trends in hospital morbidity from Alzheimer's disease in the European Union, 2000-2014
    (SAGE, 2018) Niu, Hao; Álvarez Álvarez, Ismael; Aguinaga Ontoso, Inés; Guillén Grima, Francisco; Ciencias de la Salud; Osasun Zientziak
    Background: Alzheimer’s disease (AD) has become a concerning public health issue. We aimed to analyse the trends of hospital morbidity from AD in the European Union (EU) in the period 2000-2014. Methods: Data from hospital discharges of men and women over 50 years old hospitalised from AD in the EU were extracted from Eurostat database. We tested for secular trends computing the annual percent change, and identifying significant changes in the linear slope of the trend. Results: Hospital morbidity from AD showed a 0.8% (95% confidence intervals -2.2, 0.6) slight declining trend in the EU. In men and women, we recorded a -0.5% and -1.0% decrease in hospital morbidity rates, respectively. Several countries showed changing trends during the study period. Conclusion: AD hospital morbidity has slightly declined in the entire EU in the past years. Eastern European countries showed steadily increasing trends, whereas in western and Mediterranean countries rates decreased or levelled off.
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    PublicationOpen Access
    Trends of mortality from Alzheimer's disease in the European Union, 1994-2013
    (Wiley, 2017) Niu, Hao; Álvarez Álvarez, Ismael; Guillén Grima, Francisco; Jamal Saad Al-Rahamneh, Moad; Aguinaga Ontoso, Inés; Ciencias de la Salud; Osasun Zientziak
    Background: In many countries, Alzheimer’s disease (AD) has gradually become a relevant disease in elderly populations. The aim of this study was to analyse trends of mortality caused by AD in the 28 member countries in the European Union (EU) over the last two decades. Methods: We extracted data for AD deaths for the period 1994-2013 in the EU from the Eurostat and World Health Organization database. Age-standardised mortality rates per 100,000 were computed. Joinpoint regression was used to analyse the trends and compute the annual percent change (APC) in the EU as a whole and by country. Analyses by gender and by European regions were conducted. Results: Throughout the study period, mortality from AD has risen in the EU. Most of the countries showed upward trends, with the sharpest increases in Slovakia, Lithuania and Romania. In men and women, we recorded a 4.7% and 6.0% statistically significant increase in mortality rates in the whole EU, respectively. Several countries showed changing trends during the study period. According to the regional analysis, Northern and Eastern countries showed the steepest increases, while in the latter years in Western countries mortality has declined. Conclusions: Our findings provide evidence that AD mortality has increased in the EU, especially in Eastern and Northern European countries and in the female population. Our results could be a reference for the development of primary prevention policies.