Aguinaga Ontoso, Inés

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Aguinaga Ontoso

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Inés

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Ciencias de la Salud

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Now showing 1 - 10 of 34
  • PublicationOpen Access
    Meta-analysis of prevalence of wheezing and recurrent wheezing in infants
    (Elsevier, 2016) Álvarez Álvarez, Ismael; Niu, Hao; Guillén Grima, Francisco; Aguinaga Ontoso, Inés; Ciencias de la Salud; Osasun Zientziak
    Background: Wheezing affects children’s quality of life, and is related with asthma in childhood. Although prevalence of wheezing has been previously studied in several countries, there are no reference of worldwide prevalence in infants. The aim of this meta-analysis is to estimate the prevalence of wheezing and recurrent wheezing in infants aged up to two years, and compare the prevalence across world regions. Methods: Literature search was conducted in MEDLINE and SCOPUS databases, looking for observational studies published up to June 2016, including as keywords “prevalence” or “epidemiology” combined with “wheeze”, “wheezing” or “asthma symptoms” and “infant” or “preschool”. Fast*Pro software and random effects Bayesian model were used. Heterogeneity was estimated using I2 statistic, and sensitivity analyses were performed. Results: We identified 109 studies after duplicates were removed. After exclusions, 14 studies were included in the meta-analysis. Prevalence of wheezing and recurrent wheezing were 36.06% (95% CI 35.17-36.96), and 17.41% (95% CI 16.74-18.09), respectively. In European countries, prevalence of wheezing was 30.68% (95% CI 28.97-32.45), and 12.35% (95% CI 11.27-13.47) for recurrent wheezing. Prevalence of wheezing and recurrent wheezing in Latin America were higher, 40.55% (95% CI 39.40-41.71), and 19.27% (95% CI 18.44-20.11), respectively. In Africa, prevalence of wheezing was 15.97% (95% CI 14.05-18.00). Low or no heterogeneity was found in all cases. Conclusions: More than one third of infants suffer from wheezing and almost one fifth from recurrent wheezing, being these illnesses especially prevalent in Latin American countries, pointing out an important public health problem.
  • PublicationOpen Access
    Prevalence and risk factors for wheezing in infants in the region of Pamplona, Spain
    (Elsevier, 2016) Álvarez Álvarez, Ismael; Niu, Hao; Aguinaga Ontoso, Inés; Guillén Grima, Francisco; Ciencias de la Salud; Osasun Zientziak; Gobierno de Navarra / Nafarroako Gobernua: 6106
    Background: Wheezing in the first year of life affects life’s quality of the baby and the family. Risk factors such as male gender, nursery attending or a family history of asthma, and protective factors such as breastfeeding more than 6 months have been previously described. The aim of this study is to study the prevalence and risk factors for wheezing ever and recurrent wheezing in the first year of life in infants in the region of Pamplona, Spain. Material and methods: This cross-sectional study was part of the International Study of Wheezing in Infants (Estudio Internacional de Sibilancias en Lactantes, EISL). Between 2006 and 2008, participating families answered a standardized validated questionnaire on respiratory symptoms, environmental factors or family issues. An analysis with the chi square test (statistical significance p<0.05) identified the risk factors for wheezing ever and recurrent wheezing, which were assessed using logistic regression. Results: 1065 questionnaires were answered. The prevalence of wheezing ever and recurrent wheezing were 31.2% and 12.3%, respectively. Male gender (p=<0.001), a history of pneumonia (p=<0.001) or nursery attendance (p=<0.001) were some of the risk factors found for wheezing ever. Infant eczema (p=<0.001), nursery attendance (p=<0.001) or prematurity (p=<0.001) were risk factors for recurrent wheezing. No associations with duration of breastfeeding (p=0.116 and p=0.851) or mould stains at home (p=0.153 and p=0.992) were found. Conclusion: The study of prevalence and risk factors for wheezing shows the importance of this public health problem, and allows the development of control and treatment strategies against preventable factors.
  • PublicationOpen Access
    Maternal mortality in Africa: regional trends (2000-2017)
    (MDPI, 2022) Onambele, Luc; Ortega-Leon, Wilfrido; Guillén Aguinaga, Sara; Forjaz, Maria Joao; Yoseph, Amanuel; Guillén Aguinaga, Laura; Alas Brun, Rosa María; Arnedo Pena, Alberto; Aguinaga Ontoso, Inés; Guillén Grima, Francisco; Ciencias de la Salud; Osasun Zientziak
    Background: United Nations Sustainable Development Goals state that by 2030, the global maternal mortality rate (MMR) should be lower than 70 per 100,000 live births. MMR is still one of Africa’s leading causes of death among women. The leading causes of maternal mortality in Africa are hemorrhage and eclampsia. This research aims to study regional trends in maternal mortality (MM) in Africa. Methods: We extracted data for maternal mortality rates per 100,000 births from the United Nations Children’s Fund (UNICEF) databank from 2000 to 2017, 2017 being the last date available. Joinpoint regression was used to study the trends and estimate the annual percent change (APC). Results: Maternal mortality has decreased in Africa over the study period by an average APC of −3.0% (95% CI −2.9; −3,2%). All regions showed significant downward trends, with the greatest decreases in the South. Only the North African region is close to the United Nations’ sustainable development goals for Maternal mortality. The remaining Sub-Saharan African regions are still far from achieving the goals. Conclusions: Maternal mortality has decreased in Africa, especially in the South African region. The only region close to the United Nations’ target is the North African region. The remaining Sub-Saharan African regions are still far from achieving the goals. The West African region needs more extraordinary efforts to achieve the goals of the United Nations. Policies should ensure that all pregnant women have antenatal visits and give birth in a health facility staffed by specialized personnel.
  • PublicationOpen Access
    Infant mortality in the European Union: a time trend analysis of the 1994-2015 period
    (Elsevier España, 2019) Onambele, Luc; San Martín Rodríguez, Leticia; Niu, Hao; Álvarez Álvarez, Ismael; Arnedo Pena, Alberto; Guillén Grima, Francisco; Aguinaga Ontoso, Inés; Ciencias de la Salud; Osasun Zientziak
    Introducción: La mortalidad infantil es un indicador de la salud infantil y una variable explicativa del desarrollo socioeconómico. Nuestro objetivo fue examinar los cambios y tendencias de la mortalidad infantil en la Unión Europea (UE) y sus 28 países miembros en el período 1994-2015. Métodos: Se recopilaron datos de muertes de niños menores de un año entre 1994 y 2015 de la base de datos Eurostat. Estudiamos las tendencias en la UE, por países y regiones, utilizando elanálisis de regresión joinpoint. Se condujeron análisis adicionales para estudiar las tendencias de mortalidad neonatal y neonatal precoz. Resultados: La mortalidad infantil en la UE ha disminuido significativamente de 8.3 a 3.6 por 1.000 (porcentaje de cambio anual = −3.8%, intervalos de confianza del 95% −4.1; −3.6). Las tasas de mortalidad más altas se registraron en Rumanía y Bulgaria, y las tasas más bajas en países escandinavos (Finlandia, Suecia). Se encontraron tendencias descendentes significativas en los países de la UE, más pronunciadas en los países bálticos exsoviéticos y países de Europa oriental, mientras que los países de Europa occidental mostraron los descensos menos pronunciados. La mortalidad infantil ha aumentado significativamente en Grecia en los últimos años,mientras que en el Reino Unido e Irlanda las tasas se han estabilizado. Conclusiones: La mortalidad infantil ha disminuido en la UE y sus países en las últimas décadas, más pronunciadamente en los países de Europa oriental y los países bálticos exsoviéticos, mientras que en varios países de Europa occidental las tasas aumentaron o se han estabilizado enlos últimos años.
  • PublicationOpen Access
    Trends in hospital morbidity from Alzheimer's disease in the European Union, 2000-2014
    (SAGE, 2018) Niu, Hao; Álvarez Álvarez, Ismael; Aguinaga Ontoso, Inés; Guillén Grima, Francisco; Ciencias de la Salud; Osasun Zientziak
    Background: Alzheimer’s disease (AD) has become a concerning public health issue. We aimed to analyse the trends of hospital morbidity from AD in the European Union (EU) in the period 2000-2014. Methods: Data from hospital discharges of men and women over 50 years old hospitalised from AD in the EU were extracted from Eurostat database. We tested for secular trends computing the annual percent change, and identifying significant changes in the linear slope of the trend. Results: Hospital morbidity from AD showed a 0.8% (95% confidence intervals -2.2, 0.6) slight declining trend in the EU. In men and women, we recorded a -0.5% and -1.0% decrease in hospital morbidity rates, respectively. Several countries showed changing trends during the study period. Conclusion: AD hospital morbidity has slightly declined in the entire EU in the past years. Eastern European countries showed steadily increasing trends, whereas in western and Mediterranean countries rates decreased or levelled off.
  • PublicationOpen Access
    Prevalencia e incidencia de la enfermedad de Alzheimer en Europa: metaanálisis
    (Elsevier España, 2017) Niu, Hao; Álvarez Álvarez, Ismael; Guillén Grima, Francisco; Aguinaga Ontoso, Inés; Ciencias de la Salud; Osasun Zientziak
    Introducción: La enfermedad de Alzheimer es el principal tipo de demencia, y una enfermedad de etiología desconocida. Con el aumento de la población anciana mundial, el número de pacientes con enfermedad de Alzheimer muestra una tendencia de crecimiento rápido. El objetivo de este metaanálisis es evaluar la prevalencia e incidencia de la enfermedad de Alzheimer en Europa. Metodología: La búsqueda de artículos se realizó en las bases de datos Medline, Scopus y CINAHL Complete utilizando las palabras claves “Alzheimer”, “Alzheimer’s disease” y “AD”; combinadas con “prevalence”, “incidence” y “epidemiology”. Se utilizó el modelo Bayesiano de efectos aleatorios, mostrando intervalos de credibilidad al 95%. Para estimar la heterogeneidad se usó el estadístico I2. Resultados: La prevalencia de enfermedad de Alzheimer en Europa fue 5,05% (IC 95% 4,73-5,39). La prevalencia por sexo en los hombres y las mujeres fue 3,31% (IC 95% 2,85-3,80) y 7,13% (IC 95% 6,56-7,72), respectivamente, y se encontró una tendencia creciente por grupos de edad. La incidencia de enfermedad de Alzheimer en Europa fue 11,08 por 1000 personas-año (IC 95% 10,30-11,89), siendo en los hombres y las mujeres de 7,02 por 1000 personas-año (IC 95% 6,06-8,05) y 13,25 por 1000 personas-año (IC 95% 12,05-14,51), respectivamente, con igual tendencia creciente con el aumento de la edad. Conclusiones: Los resultados del metaanálisis permiten una mejor comprensión de la enfermedad y su impacto en Europa.
  • PublicationOpen Access
    Variability in the control of type 2 diabetes in primary care and its association with hospital admissions for vascular events. The APNA study
    (MDPI, 2021) Guillén Aguinaga, Sara; Forga, Lluís; Brugos Larumbe, Antonio; Guillén Grima, Francisco; Guillén Aguinaga, Laura; Aguinaga Ontoso, Inés; Ciencias de la Salud; Osasun Zientziak
    Type 2 diabetes (T2D) is associated with increased cardiovascular morbidity, mortality, and hospital admissions. This study aimed to analyze how the differences in delivered care (variability of glycosylated hemoglobin (HbA1c) achieved targets) affect hospital admissions for cardiovascular events (CVEs) in T2D patients. Methods: We analyzed the electronic records in primary care health centers at Navarra (Spain) and hospital admission for CVEs. We followed 26,435 patients with T2D from 2012 to 2016. The variables collected were age, sex, health center, general practitioner practice (GPP), and income. The clinical variables were diagnosis of T2D, weight, height, body mass index (BMI), blood pressure (BP), HbA1c, low-density lipoprotein cholesterol (LDL-C), smoking, and antecedents of CVEs. We calculated, in each GPP practice, the proportion of patients with HbA1c ≥ 9. A non-hierarchical K-means cluster analysis classified GPPs into two clusters according to the level of compliance with HbA1C ≥ 9% control indicators. We used logistic and Cox regressions. Results: T2D patients had a higher probability of admission for CVEs when they belonged to a GPP in the worst control cluster of HbA1C ≥ 9% (HR = 1.151; 95% CI, 1.032–1.284).
  • PublicationOpen Access
    The impact of COVID-19 on DTP3 vaccination coverage in Europe (2012-2023)
    (MDPI, 2025-12-24) Aguinaga Ontoso, Inés; Guillén Aguinaga, Sara; Guillén Aguinaga, Laura; Alas Brun, Rosa María; Guillén-Aguinaga, Miriam; Onambele, Luc; Aguinaga Ontoso, Enrique; Rayón Valpuesta, Esperanza; Guillén Grima, Francisco; Ciencias de la Salud; Osasun Zientziak
    Background: The COVID-19 pandemic disrupted routine child immunization efforts, threatening to reverse progress in controlling vaccine-preventable diseases. Materials and Methods: We analyzed the impact of COVID-19 on DTP3 vaccination in Europe by comparing trends before and after the pandemic using time series data from 2000 to 2023. Employing joinpoint regression, chi-square tests, and segmented regression analysis, we assessed DTP3 vaccination trends and coverage changes. Results: The findings revealed significant regional disparities across Europe. Statistical models indicated reductions in DTP3 coverage in countries such as Ireland, Sweden, and Switzerland, whereas Ukraine and San Marino showed improvements. Conclusions: There are variations in the effect of COVID-19 on DTP3 coverage rates, indicating the need for targeted public health strategies to address vaccine hesitancy, logistical barriers, and systemic inequities.
  • PublicationOpen Access
    Prevalencia de actividad física y su relación con variables sociodemográficas y estilos de vida en la población de 18 a 65 años de Pamplona
    (Ministerio de Sanidad, Servicios Sociales e Igualdad, 2005) Elizondo Armendáriz, José Javier; Guillén Grima, Francisco; Aguinaga Ontoso, Inés; Ciencias de la Salud; Osasun Zientziak
    Fundamento: los conocimientos actuales permiten considerar que existe una asociación de tipo causal entre el nivel de actividad física y la aparición de diversas enfermedades. A pesar de ello, la actividad física es una práctica poco arraigada en la población, que cada vez se está haciendo más sedentaria. El objetivo de este estudio es describir la prevalencia de sedentarismo en la población de Pamplona, así como conocer cuáles son los factores que más influyen en él. Métodos: se llevó a cabo un estudio transversal mediante encuesta postal en una muestra significativa de la población de Pamplona de 18 a 65 años. La encuesta utilizada incluía una evaluación de la actividad física realizada, basada en el cuestionario de actividad física de Paffenbarger. Se realizó un análisis bivariado y multivariado con aplicación de regresión logística. Resultados: un 76,6% de las mujeres tienen un estilo de vida sedentario, mientras que en los varones este porcentaje se reduce hasta un 56,7%. El sedentarismo se incrementa con la edad, existiendo hasta un 80,3% de varones sedentarios en el grupo de mayor edad, y un 86,3% entre las mujeres, respectivamente. Conclusiones: los factores sociodemográficos como sexo, edad, estudios, profesión y estado civil parecen ser determinantes del estilo de vida sedentario, mientras el consumo de tabaco y la existencia de sobrepeso y obesidad no lo son. Entre las personas jóvenes, las mujeres sin estudios universitarios y los varones casados y fumadores parecen ser poblaciones diana para la promoción de la actividad física.
  • PublicationOpen Access
    Influence of the Mediterranean diet during pregnancy in the development of wheezing and eczema in infants in Pamplona, Spain
    (Codon Publications, 2017-06-17) Álvarez Zallo, Noelia; Aguinaga Ontoso, Inés; Álvarez Álvarez, Ismael; Marín Fernández, Blanca; Guillén Grima, Francisco; Azcona San Julián, María Cristina; Ciencias de la Salud; Osasun Zientziak; Gobierno de Navarra / Nafarroako Gobernua
    Background: this study examined the relationship between different food groups and the adherence to a Mediterranean diet during pregnancy and the risk of wheezing and eczema in children aged 12-15 months. Methods: the study involves 1087 Spanish infants from the International Study of Wheezing in Infants (Estudio Internacional de Sibilancias en Lactantes, EISL). The study of the association of the different food consumption and Mediterranean diet with wheezing, recurrent wheezing and eczema was performed using different models of unconditional logistic regression to obtain adjusted prevalence odds ratios (OR) and 95% confidence intervals (95% CI). Results: no association was found between a good adherence to the Mediterranean diet during pregnancy and the development of wheezing (p=0.372), recurrent wheezing (p=0.118) and eczema (p=0.315). The consumption once or twice a week of white fish (OR: 1.95[1.01-3.75]), cooked potatoes (OR: 1.75[1.22-2.51]) and industrial pastry (OR: 1.59[1.13-2.24]), and the consumption more than three times a week of industrial pastry (OR: 1.47 [1.01-2.13]) during pregnancy increases the risk of "wheezing" at 12 months. Instead, high fruit consumption during the pregnancy has a protective effect against "wheezing" in 12-month-old infants (OR: 0.44 [0.20-0.99]). No statistically significant differences were observed between food intake during pregnancy and "recurrent wheezing". No statistically significant differences were observed between the consumption of any food during pregnancy and the presence of eczema at 12 months. Conclusions: the present study showed that the consumption of Mediterranean diet during pregnancy did not have a protective effect for wheezing, recurrent wheezing or eczema.