Sánchez Sánchez, Juan Luis

Profile Picture

Email Address

person.page.identifierURI

https://academica-e.unavarra.es/handle/2454/49968

Birth Date

Job Title

Last Name

Sánchez Sánchez

First Name

Juan Luis

person.page.departamento

Ciencias de la Salud

person.page.instituteName

ORCID

person.page.observainves

751429

person.page.upna

812475

Name

Filters

2020 - 20233
Reset filters

Settings

Subject: Healthy aging ×

Search Results

Now showing 1 - 3 of 3
  • Thumbnail Image
    PublicationOpen Access
    Periostin plasma levels and changes on physical and cognitive capacities in community-dwelling older adults
    (Oxford University Press, 2023) Sánchez Sánchez, Juan Luis; Ader, Isabelle; Jeanson, Yannick; Planat-Benard, Valérie; Vellas, Bruno; Casteilla, Louis; Souto Barreto, Philipe de; Ciencias de la Salud; Osasun Zientziak
    Periostin, involved in extracellular matrix development and support, has been shown to be elevated in senescent tissues and fibrotic states, transversal signatures of aging. We aimed to explore associations between plasma periostin and physical and cognitive capacity evolution among older adults. Our hypothesis was that higher levels of plasma periostin will be associated with worse physical and mental capacities along time. Analyses included 1 096 participants (mean age = 75.3 years ± 4.4; 63.9% women) from the Multidomain Alzheimer Preventive Trial. Periostin levels (pg/mL) were measured in plasma collected at year 1. Periostin was used in continuous variable, and as a dichotomous variable highest quartile (POSTN+) versus lowest 3 quartiles (POSTN−) were used. Outcomes were measured annually over 4 years and included: gait speed (GS), short physical performance battery (SPPB) score, 5-times sit-to-stand test (5-STS), and handgrip strength (HS) as physical and cognitive composite z-score (CCS) and the Mini-Mental State Examination (MMSE) as cognitive endpoints. Plasma periostin as a continuous variable was associated with the worsening of physical and cognitive capacities over 4 years of follow-up, specifically the SPPB score, the 5-STS, and CCS in full-adjusted models. POSTN+ was associated with worse evolution in the physical (GS: [β = −0.057, 95% confidence interval (CI) = −0.101, −0.013], SPPB score [β = −0.736, 95% CI = −1.091, −0.381], 5-STS [β = 1.681, 95% CI = 0.801, 2.561]) as well as cognitive (CCS [β = −0.215, 95% CI = −0.335, −0.094]) domains compared to POSTN− group. No association was found with HS or the MMSE score. Our study showed for the first time that increased plasma periostin levels were associated with declines in both physical and cognitive capacities in older adults over a 4-year follow-up. Further research is needed to evaluate whether periostin might be used as a predictive biomarker of functional decline at an older age.
  • Thumbnail Image
    PublicationOpen Access
    Physical activity trajectories, mortality, hospitalization, and disability in the Toledo Study of Healthy Aging
    (Wiley, 2020) Sánchez Sánchez, Juan Luis; Izquierdo Redín, Mikel; Carnicero Carreño, José Antonio; García García, Francisco José; Rodríguez Mañas, Leocadio; Ciencias de la Salud; Osasun Zientziak
    Background: Physical activity (PA) is a recognized contributor to healthy aging. However, the majority of studies exploring its associations with adverse outcomes in cohorts of older adults use single-time PA estimates, which do not consider its dynamic nature. The aim of the present study is to explore the presence of different PA trajectories in the Toledo Study of Healthy Aging and their association with adverse outcomes. Our hypothesis is that prospectively maintaining or increasing PA is associated with a reduced risk of adverse outcomes. Methods: We used data from 1679 participants enrolled in the Toledo Study of Healthy Aging. Trajectories based on the Physical Activity Scale for the Elderly were identified using group-based trajectory modelling. Cox and logistic regression were used to investigate associations between PA trajectories and mortality and hospitalization, and incident and worsening disability, respectively. Mortality was ascertained by linkage to the Spanish National Death Index; disability was evaluated through the Katz Index; and hospitalization was defined as the first admission to Toledo Hospital. Models were adjusted by age, sex, smoking, Charlson Index, education, cognitive impairment, polypharmacy, and Katz Index at Wave 2. Results: We found four PA-decreasing and one PA-increasing trajectories: high PA-consistent (n = 566), moderate PA-mildly decreasing (n = 392), low PA-increasing (n = 237), moderate PA-consistent (n = 191), and low PA-decreasing (n = 293). Belonging to the high PA-consistent trajectory group was associated with reduced risks of mortality as compared with the low PA-decreasing group [hazard ratio (HR) 1.68; 95% confidence interval (CI) = 1.21–2.31] and hospitalization compared with the low PA-increasing and low PA-decreasing trajectory groups (HR 1.24; 95% CI = 1.004–1.54 and HR 1.25; 95% CI = 1.01–1.55, respectively) and with lower rates of incident [odds ratio (OR) 3.14; 95% CI = 1.59–6.19] and worsening disability (OR 2.16; 95% CI = 1.35–3.45) in relation to the low PA-decreasing trajectory group and at follow-up. Increasing PA during late life (low PA-increasing group) was associated with lower incident disability rates (OR 0.38; 95% CI = 0.19–0.82) compared with decreasing PA (low PA-decreasing group), despite similar baseline PA. Conclusions: Our results suggest that sustaining higher PA levels during aging might lead to healthy aging, characterized by a reduction in adverse outcomes. Our study supports the need for enhancing PA participation among older populations, with the goal of reducing personal and economic burden in a worldwide aging population.
  • Thumbnail Image
    PublicationOpen Access
    Physical behaviors, sarcopenia and adverse events in the Toledo Study of Healthy Ageing
    (2020) Sánchez Sánchez, Juan Luis; Izquierdo Redín, Mikel; Rodríguez Mañas, Leocadio; Ciencias de la Salud; Osasun Zientziak
    El envejecimiento de la población es un fenómeno global que puede tener unas implicaciones relevantes tanto a nivel de la salud individual como en los sistemas sanitarios. Esto se debe a que los aumentos en la esperanza de vida observados en los últimos siglos no se han visto acompañados concurrentemente de aumentos de los años vividos sin enfermedad. El desarrollo de enfermedades crónicas y su aparición en forma de comorbilidad unido a los efectos del envejecimiento primario ha derivado en la progresiva pérdida de función y el desarrollo de discapacidad. El envejecimiento saludable se define como el mantenimiento de la capacidad funcional que garantiza el bienestar en el adulto mayor. En contraposición, la acumulación de patologías y la presencia de estilos de vida no saludables pueden condicionar un envejecimiento acelerado y la emergencia prematura de la discapacidad. La pérdida de masa y función muscular que acompaña al envejecimiento (sarcopenia), constituye una de las piedras angulares en el desarrollo de la discapacidad en el anciano. El ejercicio físico ha sido propuesto como la herramienta de elección para mantener y aumentar la función física en ancianos y, por ende, prevenir el deterioro funcional asociado con la sarcopenia. Sin embargo, muy pocos sujetos ancianos participan en programas estructurados de ejercicio y los parámetros óptimos de esos programas se desconocen. En ese contexto, los comportamientos físicos espontáneos (comportamiento sedentario y actividad física), podrían ser determinantes relevantes de la capacidad funcional en el anciano. La incorporación de medidas objetivas en la epidemiología de la actividad física y el reciente desarrollo de nuevos métodos estadísticos ha permitido atender preguntas de investigación como las asociaciones del sedentarismo y distintos niveles de intensidad de actividad física con parámetros de salud e incorporar la naturaleza dinámica de los comportamientos físicos como factor determinante de salud. La presente tesis doctoral pretende profundizar en las asociaciones entre los niveles de actividad física y sedentarismo e indicadores de envejecimiento saludable (sarcopenia y eventos adversos), superando algunas limitaciones identificadas en la evidencia previa. En la misma se han incluido dos trabajos realizados con datos del Estudio de Toledo del Envejecimiento Saludable, un estudio poblacional en curso.