Person: Garayo Urabayen, Eneko
Loading...
Email Address
Birth Date
Research Projects
Organizational Units
Job Title
Last Name
Garayo Urabayen
First Name
Eneko
person.page.departamento
Ciencias
ORCID
0000-0002-3144-7898
person.page.upna
811381
Name
1 results
Search Results
Now showing 1 - 1 of 1
Publication Open Access Unlocking the potential of magnetotactic bacteria as magnetic hyperthermia agents(Wiley, 2019) Gandía, David; Gandarias, Lucía; Rodrigo, Irati; Robles García, Joshua; Das, Raja; Garayo Urabayen, Eneko; García, José Ángel; Ciencias; ZientziakMagnetotactic bacteria are aquatic microorganisms that internally biomineralize chains of magnetic nanoparticles (called magnetosomes) and use them as a compass. Here it is shown that magnetotactic bacteria of the strain Magnetospirillum gryphiswaldense present high potential as magnetic hyperthermia agents for cancer treatment. Their heating efficiency or specific absorption rate is determined using both calorimetric and AC magnetometry methods at different magnetic field amplitudes and frequencies. In addition, the effect of the alignment of the bacteria in the direction of the field during the hyperthermia experiments is also investigated. The experimental results demonstrate that the biological structure of the magnetosome chain of magnetotactic bacteria is perfect to enhance the hyperthermia efficiency. Furthermore, fluorescence and electron microscopy images show that these bacteria can be internalized by human lung carcinoma cells A549, and cytotoxicity studies reveal that they do not affect the viability or growth of the cancer cells. A preliminary in vitro hyperthermia study, working on clinical conditions, reveals that cancer cell proliferation is strongly affected by the hyperthermia treatment, making these bacteria promising candidates for biomedical applications.