Regulation of Bax mitochondrial localization by Bcl-2 and Bcl-xL: keep your friends close but your enemies closer

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dc.contributor.authorRenault, Thibaud T.
dc.contributor.authorTeijido Hermida, Óscar
dc.contributor.authorAntonsson, Bruno
dc.contributor.authorDejean, Laurent M.
dc.contributor.authorManon, Stéphen
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.date.accessioned2025-01-29T12:07:50Z
dc.date.available2025-01-29T12:07:50Z
dc.date.issued2013
dc.date.updated2025-01-29T12:04:56Z
dc.descriptionAcceso cerrado a este documento. No se encuentra disponible para la consulta pública. Depositado en Academica-e para cumplir con los requisitos de evaluación y acreditación académica del autor/a (sexenios, acreditaciones, etc.).
dc.description.abstractBax-induced mitochondrial outer membrane permeabilization (MOMP) is considered as one of the key control switches of apoptosis. MOMP requires Bax relocation to and insertion into the outer mitochondrial membrane to oligomerize and form pores allowing the release of apoptogenic factors such as cytochrome c. Even if these essential steps are now well-defined, it is necessary to better understand the molecular changes underlying the switch between inactive Bax and active (pore-forming) Bax. One of the ongoing issues is to determine whether Bax mitochondrial translocation is a critical step in the control of Bax activation or if this control is carried by latter regulatory steps. In this focus article we discuss recent data suggesting that although Bcl-2 and Bcl-xL block the MOMP, they can also regulate the mitochondrial Bax content. A new model in which Bax inhibition by Bcl-xL occurs at the immediate proximity of the outer mitochondrial membrane is also discussed. This article is part of a Directed Issue entitled: Bioenergetic dysfunction, adaptation and therapy.
dc.format.mimetypeapplication/pdfen
dc.identifier.citationRenault, T. T., Teijido, O., Antonsson, B., Dejean, L. M., Manon, S. (2013) Regulation of bax mitochondrial localization by Bcl-2 and Bcl-xL: keep your friends close but your enemies closer. International Journal of Biochemistry and Cell Biology, 45(1), 64-67. https://doi.org/10.1016/j.biocel.2012.09.022.
dc.identifier.doi10.1016/j.biocel.2012.09.022
dc.identifier.issn1357-2725
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/53151
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofInternational Journal of Biochemistry and Cell Biology 45(1), 64-67
dc.relation.publisherversionhttps://doi.org/10.1016/j.biocel.2012.09.022
dc.rights.accessRightsinfo:eu-repo/semantics/closedAccess
dc.subjectBax
dc.subjectBcl-2 family
dc.subjectMitochondria
dc.subjectApoptosis
dc.titleRegulation of Bax mitochondrial localization by Bcl-2 and Bcl-xL: keep your friends close but your enemies closeren
dc.typeinfo:eu-repo/semantics/article
dspace.entity.typePublication
relation.isAuthorOfPublication2af87636-fad2-48e3-b5f6-f4a704d93613
relation.isAuthorOfPublication.latestForDiscovery2af87636-fad2-48e3-b5f6-f4a704d93613

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