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Multi-platform detection of small ruminant lentivirus antibodies and provirus as biomarkers of production losses

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dc.contributor.authorEcheverría Garín, Irache
dc.contributor.authorMiguel, Ricardo de
dc.contributor.authorPablo Maiso, Lorena de
dc.contributor.authorGlaría Ezquer, Idoia
dc.contributor.authorBenito, Alfredo A.
dc.contributor.authorBlas, Ignacio de
dc.contributor.authorAndrés Cara, Damián de
dc.contributor.authorLuján, Lluís
dc.contributor.authorReina Arias, Ramsés
dc.contributor.departmentAgronomía, Biotecnología y Alimentaciónes_ES
dc.contributor.departmentAgronomia, Bioteknologia eta Elikaduraeu
dc.date.accessioned2024-06-06T08:41:06Z
dc.date.available2024-06-06T08:41:06Z
dc.date.issued2020
dc.date.updated2024-06-06T08:19:20Z
dc.description.abstractSmall ruminant lentiviruses (SRLVs) are endemic in most areas of Europe, causing a chronic infection and a multisystemic disease affecting the udder, carpal joints, lungs, and central nervous system. Due to the lack of treatments and protective vaccination strategies, infection control is focused on the identification of infected animals through serological or molecular techniques. However, antigenic and genetic heterogeneity of SRLVs represent a clear drawback for diagnosis. Infected animals may present lower animal production parameters such as birth weight or milk production and quality, depending on productive systems considered and, likely, to the diagnostic method applied. In this study, four sheep flocks dedicated to dairy or meat production were evaluated using three different ELISA and two PCR strategies to classify animal population according to SRLV infection status. Productive parameters were recorded along one whole lactation or reproductive period and compared between positive and negative animals. SRLV was present in 19% of the total population, being unequally distributed in the different flocks. Less than half of the infected animals were detected by a single diagnostic method, highlighting the importance of combining different diagnostic techniques. Statistical analysis employing animal classification using all the diagnostic methods associated lambing size, lamb weight at birth, and daily weight gain with SRLV infection status in meat flocks. Milk production, somatic cell count, fat, and protein content in the milk were associated with SRLV infection in dairy flocks, to a greater extent in the flock showing higher seroprevalence. A multi-platform SRLV diagnostic strategy was useful for ensuring correct animal classification, thus validating downstream studies investigating production traits.en
dc.description.sponsorshipThis research was funded by the Spanish Ministry of Science, Innovation and Universities, grant number RTI2018-096172-BC31, and by the Government of Navarra and European Union ERDF program, grant number PDR (210160006).en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationEcheverría, I., De Miguel, R., De Pablo-Maiso, L., Glaria, I., Benito, A. A., De Blas, I., De Andrés, D., Luján, L., Reina, R. (2020) Multi-platform detection of small ruminant lentivirus antibodies and provirus as biomarkers of production losses. Frontiers in Veterinary Science, 7, 1-10. https://doi.org/10.3389/fvets.2020.00182.es_ES
dc.identifier.doi10.3389/fvets.2020.00182
dc.identifier.issn2297-1769
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/48262
dc.language.isoengen
dc.publisherFrontiers Mediaen
dc.relation.ispartofFrontiers in Veterinary Science (2020), vol. 7es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-096172-B-C31/ES/en
dc.relation.projectIDinfo:eu-repo/grantAgreement/Gobierno de Navarra//210160006en
dc.relation.publisherversionhttps://doi.org/10.3389/fvets.2020.00182
dc.rights© 2020 Echeverría, De Miguel, De Pablo-Maiso, Glaria, Benito, De Blas, De Andrés, Luján and Reina. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectSmall ruminant lentivirusesen
dc.subjectDiagnosisen
dc.subjectMilk productionen
dc.subjectSomatic cell counten
dc.subjectBody weighten
dc.subjectLambing sizeen
dc.subjectELISAen
dc.subjectPCRen
dc.titleMulti-platform detection of small ruminant lentivirus antibodies and provirus as biomarkers of production lossesen
dc.typeinfo:eu-repo/semantics/article
dc.type.versionVersión publicada / Argitaratu den bertsioaes
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dspace.entity.typePublication
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