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Revisiting skeletal myopathy and exercise training in heart failure: emerging role of myokines

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dc.contributor.authorRamírez Vélez, Robinson
dc.contributor.authorGonzález, Arantxa
dc.contributor.authorGarcía Hermoso, Antonio
dc.contributor.authorLatasa Amézqueta, Íñigo
dc.contributor.authorIzquierdo Redín, Mikel
dc.contributor.authorDíez, Javier
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.contributor.funderUniversidad Pública de Navarra / Nafarroako Unibertsitate Publikoaes
dc.date.accessioned2023-02-16T07:43:33Z
dc.date.available2023-02-16T07:43:33Z
dc.date.issued2023
dc.date.updated2023-02-16T07:25:27Z
dc.description.abstractExercise intolerance remains a major unmet medical need in patients with heart failure (HF). Skeletal myopathy is currently considered as the major limiting factor for exercise capacity in HF patients. On the other hand, emerging evidence suggest that physical exercise can decrease morbidity and mortality in HF patients. Therefore, mechanistic insights into skeletal myopathy may uncover critical aspects for therapeutic interventions to improve exercise performance in HF. Emerging data reviewed in this article suggest that the assessment of circulating myokines (molecules synthesized and secreted by skeletal muscle in response to contraction that display autocrine, paracrine and endocrine actions) may provide new insights into the pathophysiology, phenotyping and prognostic stratification of HF-related skeletal myopathy. Further studies are required to determine whether myokines may also serve as biomarkers to personalize the modality and dose of physical training prescribed for patients with HF and exercise intolerance. In addition, the production and secretion of myokines in patients with HF may interact with systemic alterations (e.g., inflammation and metabolic disturbances), frequently present in patients with HF. Furthermore, myokines may exert beneficial or detrimental effects on cardiac structure and function, which may influence adverse cardiac remodelling and clinical outcomes in HF patients. Collectively, these data suggest that a deeper knowledge on myokines regulation and actions may lead to the identification of novel physical exercise-based therapeutic approaches for HF patients.en
dc.description.sponsorshipInstituto de Salud Carlos III (Spain) (CB16/11/00483 to JD, PI18/01469 co-financed by “Fondos Europeos de Desarrollo Regional to AG, CP18/0150 Miguel Servet Fellow to AG-H); Ministerio de Ciencia e Innovación (Spain) (PID2020-113098RB-I00 to MI); European Commission CRUCIAL project (grant agreement 848109 to AG). Open access funding provided by Universidad Pública de Navarra.en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationRamírez-Vélez R., González, A.,, García-Hermoso, A., Amézqueta, I. L., Izquierdo, M., Díez, J. (2023) Revisiting skeletal myopathy and exercise training in heart failure: Emerging role of myokines. Metabolism, 138, 1-10. https://doi.org/10.1016/j.metabol.2022.155348.en
dc.identifier.doi10.1016/j.metabol.2022.155348
dc.identifier.issn0026-0495
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/44731
dc.language.isoengen
dc.publisherElsevieren
dc.relation.ispartofMetabolism 138 (2023) 155348en
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//CB16%2F11%2F00483/ES/en
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI18%2F01469/ES/en
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-113098RB-I00/ES/en
dc.relation.projectIDinfo:eu-repo/grantAgreement/European Commission/Horizon 2020 Framework Programme/848109en
dc.relation.publisherversionhttps://doi.org/10.1016/j.metabol.2022.155348
dc.rights© 2022 The Authors. This is an open access article under the CC BY-NC-ND license.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectHeart failureen
dc.subjectSkeletal myopathyen
dc.subjectPhysical exerciseen
dc.subjectMyokinesen
dc.subjectBiomarkersen
dc.subjectPersonalized trainingen
dc.titleRevisiting skeletal myopathy and exercise training in heart failure: emerging role of myokinesen
dc.typeinfo:eu-repo/semantics/article
dc.type.versionVersión publicada / Argitaratu den bertsioaes
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dspace.entity.typePublication
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relation.isAuthorOfPublicationef73585d-4750-4f56-9d4f-0d759232dbca
relation.isAuthorOfPublication.latestForDiscoveryd0c2c11e-01d0-46ff-93b4-36b11beaf269

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