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Th17-related genes and celiac disease susceptibility

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dc.contributor.authorMedrano, Luz María
dc.contributor.authorGarcía Magariños, Manuel
dc.contributor.authorDema, Barbara
dc.contributor.authorEspino, Laura
dc.contributor.authorMaluenda, Carlos
dc.contributor.authorPolanco, Isabel
dc.contributor.authorFigueredo, María Ángeles
dc.contributor.authorFernández Arquero, Miguel
dc.contributor.authorNúñez, Concepción
dc.contributor.departmentEstadística e Investigación Operativaes_ES
dc.contributor.departmentEstatistika eta Ikerketa Operatiboaeu
dc.date.accessioned2014-06-05T07:57:16Z
dc.date.available2014-06-05T07:57:16Z
dc.date.issued2012
dc.description.abstractTh17 cells are known to be involved in several autoimmune or inflammatory diseases. In celiac disease (CD), recent studies suggest an implication of those cells in disease pathogenesis. We aimed at studying the role of genes relevant for the Th17 immune response in CD susceptibility. A total of 101 single nucleotide polymorphisms (SNPs), mainly selected to cover most of the variability present in 16 Th17-related genes (IL23R, RORC, IL6R, IL17A, IL17F, CCR6, IL6, JAK2, TNFSF15, IL23A, IL22, STAT3, TBX21, SOCS3, IL12RB1 and IL17RA), were genotyped in 735 CD patients and 549 ethnically matched healthy controls. Case-control comparisons for each SNP and for the haplotypes resulting from the SNPs studied in each gene were performed using chi-square tests. Gene-gene interactions were also evaluated following different methodological approaches. No significant results emerged after performing the appropriate statistical corrections. Our results seem to discard a relevant role of Th17 cells on CD risk.en
dc.description.sponsorshipThis work was supported by a grant from ‘‘Fondo de Investigaciones Sanitarias’’ (CP08/00213).en
dc.format.mimetypeapplication/pdfen
dc.identifier.doi10.1371/journal.pone.0031244
dc.identifier.issn1932-6203 (electronic)
dc.identifier.other535
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/10743
dc.language.isoengen
dc.publisherPublic Library of Scienceen
dc.relation.ispartofPlos One, 2012, 7(2): e31244en
dc.relation.publisherversionhttps://dx.doi.org/10.1371/journal.pone.0031244
dc.rights© 2012 Medrano et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/
dc.subjectGenome wide associationen
dc.subjectMultiple sclerosisen
dc.subjectCrohns diseaseen
dc.subjectRisken
dc.subjectVariantsen
dc.subjectTh17 cellsen
dc.subjectIL23Ren
dc.subjectGliadinen
dc.subjectInterleukin 23en
dc.subjectAutoimmunityen
dc.subjectInflammationen
dc.titleTh17-related genes and celiac disease susceptibilityen
dc.typeinfo:eu-repo/semantics/article
dc.type.versionVersión publicada / Argitaratu den bertsioaes
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dspace.entity.typePublication
relation.isAuthorOfPublication129d485e-b0d4-4c15-92b0-802d2abb5704
relation.isAuthorOfPublication.latestForDiscovery129d485e-b0d4-4c15-92b0-802d2abb5704

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