Publication:
Nontypable haemophilus influenzae displays a prevalent surface structure molecular pattern in clinical isolates

Date

2011

Authors

Martí Lliteras, Pau
Mauro, Silvia
Hood, Derek W.
Calatayud, Laura
Morey Sancho, Pau
Servin, Alain
Liñares, Josefina
Oliver, Antonio

Director

Publisher

Public Library of Science
Acceso abierto / Sarbide irekia
Artículo / Artikulua
Versión publicada / Argitaratu den bertsioa

Project identifier

Métricas Alternativas

Abstract

Non-typable Haemophilus influenzae (NTHi) is a Gram negative pathogen that causes acute respiratory infections and is associated with the progression of chronic respiratory diseases. Previous studies have established the existence of a remarkable genetic variability among NTHi strains. In this study we show that, in spite of a high level of genetic heterogeneity, NTHi clinical isolates display a prevalent molecular feature, which could confer fitness during infectious processes. A total of 111 non-isogenic NTHi strains from an identical number of patients, isolated in two distinct geographical locations in the same period of time, were used to analyse nine genes encoding bacterial surface molecules, and revealed the existence of one highly prevalent molecular pattern (lgtF+, lic2A+, lic1D+, lic3A+, lic3B+, siaA-, lic2C+, ompP5+, oapA+) displayed by 94.6% of isolates. Such a genetic profile was associated with a higher bacterial resistance to serum mediated killing and enhanced adherence to human respiratory epithelial cells.

Description

Keywords

Outer membrane protein, C reactive protein, Epithelial cells, Otitis media, Phase variation, Biofilm communities, Serum resistance, Sialic acid, Middle ear, Inner core

Department

IdAB. Instituto de Agrobiotecnología / Agrobioteknologiako Institutua

Faculty/School

Degree

Doctorate program

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© 2011 Martí–Lliteras et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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