Biomarkers of delirium risk in older adults: a systematic review and meta-analysis

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dc.contributor.authorLozano Vicario, Lucía
dc.contributor.authorGarcía Hermoso, Antonio
dc.contributor.authorCedeño Veloz, Bernardo Abel
dc.contributor.authorFernández Irigoyen, Joaquín
dc.contributor.authorSantamaría Martínez, Enrique
dc.contributor.authorRomero Ortuno, Román
dc.contributor.authorZambom Ferraresi, Fabrício
dc.contributor.authorLópez Sáez de Asteasu, Mikel
dc.contributor.authorMuñoz-Vázquez, Ángel Javier
dc.contributor.authorIzquierdo Redín, Mikel
dc.contributor.authorMartínez Velilla, Nicolás
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.date.accessioned2023-10-25T18:23:08Z
dc.date.available2023-10-25T18:23:08Z
dc.date.issued2023
dc.date.updated2023-10-25T17:22:57Z
dc.description.abstractDelirium is a neuropsychiatric syndrome associated with increased morbidity and mortality in older patients. The aim of this study was to review predictive biomarkers of delirium in older patients to gain insights into the pathophysiology of this syndrome and provide guidance for future studies. Two authors independently and systematically searched MEDLINE, Embase, Cochrane Library, Web of Science and Scopus databases up to August 2021. A total of 32 studies were included. Only 6 studies were eligible for the meta-analysis, pooled results showed a significant increase in some serum biomarkers (C-reactive protein [CRP], tumour necrosis factor alpha [TNF-α] and interleukin-6 [IL-6]) among patients with delirium (odds ratio = 1.88, 95% CI 1.01 to 1.637; I2 = 76.75%). Although current evidence does not favour the use of any particular biomarker, serum CRP, TNF-α, and IL-6 were the most consistent biomarkers of delirium in older patients.en
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dc.identifier.citationLozano-Vicario, L., García-Hermoso, A., Cedeno-Veloz, B. A., Fernández-Irigoyen, J., Santamaría, E., Romero-Ortuno, R., Zambom-Ferraresi, F., Sáez de Asteasu, M. L., Muñoz-Vázquez, Á. J., Izquierdo, M., Martínez-Velilla, N. (2023) Biomarkers of delirium risk in older adults: a systematic review and meta-analysis. Frontiers in Aging Neuroscience, 15, 1-13. https://doi.org/10.3389/fnagi.2023.1174644.en
dc.identifier.doi10.3389/fnagi.2023.1174644
dc.identifier.issn1663-4365
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/46647
dc.language.isoengen
dc.publisherFrontiers Mediaen
dc.relation.ispartofFrontiers in Aging Neuroscience 2023, 15en
dc.relation.publisherversionhttps://doi.org/10.3389/fnagi.2023.1174644
dc.rights© 2023 Lozano-Vicario, García-Hermoso, Cedeno-Veloz, Fernández-Irigoyen, Santamaría, Romero-Ortuno, Zambom- Ferraresi, Sáez de Asteasu, Muñoz-Vázquez, Izquierdo and Martínez-Velilla. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY).en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBiomarkersen
dc.subjectCognitive impairmenten
dc.subjectDeliriumen
dc.subjectNeuroinflammationen
dc.subjectOlder peopleen
dc.titleBiomarkers of delirium risk in older adults: a systematic review and meta-analysisen
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublication
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