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Relapse, cognitive reserve and their relationship with cognition in first episode schizophrenia: a 3-year follow-up study

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dc.contributor.authorSánchez Torres, Ana María
dc.contributor.authorAmoretti, Silvia
dc.contributor.authorEnguita Germán, Mónica
dc.contributor.authorMezquida, Gisela
dc.contributor.authorMoreno-Izco, Lucía
dc.contributor.authorPanadero-Gómez, Rocío
dc.contributor.authorRementería, Lide
dc.contributor.authorToll, Alba
dc.contributor.authorRodríguez-Jiménez, Roberto
dc.contributor.authorRoldán, Alexandra
dc.contributor.authorPomarol-Clotet, Edith
dc.contributor.authorIbáñez, Ángela
dc.contributor.authorUsall, Judith
dc.contributor.authorContreras, Fernando
dc.contributor.authorVieta, Eduard
dc.contributor.authorLópez-Ilundain, José M.
dc.contributor.authorMerchán-Naranjo, Jessica
dc.contributor.authorGonzález Pinto, Ana
dc.contributor.authorBerrocoso, Esther
dc.contributor.authorBernardo, Miguel
dc.contributor.authorCuesta, Manuel J.
dc.contributor.authorForte, María Florencia
dc.contributor.authorGonzález-Díaz, Jairo M.
dc.contributor.authorParellada, Mara
dc.contributor.authorAbrokwa, Hayford
dc.contributor.authorSegura, María Sans
dc.contributor.authorGonzález, Judtih Selma
dc.contributor.authorZorrilla, Iñaki
dc.contributor.authorGonzález-Ortega, Itxaso
dc.contributor.authorLegido, Teresa
dc.contributor.authorMané, Anna
dc.contributor.authorSanchez-Pastor, Luis
dc.contributor.authorRentero, David
dc.contributor.authorSarró, Salvador
dc.contributor.authorGarcía-León, María Ángeles
dc.contributor.authorButjosa, Anna
dc.contributor.authorPardo, Marta
dc.contributor.authorZarzuela, Amalia
dc.contributor.authorRibeiro Fernández, María
dc.contributor.authorSáiz-Ruiz, Jerónimo
dc.contributor.authorLeón-Quismondo, Leticia
dc.contributor.authorHernández, Miguel
dc.contributor.authorCámara, Concepción de la
dc.contributor.authorGutiérrez-Fraile, Miguel
dc.contributor.authorGonzález-Blanco, Leticia
dc.contributor.departmentCiencias de la Saludes_ES
dc.contributor.departmentOsasun Zientziakeu
dc.date.accessioned2023-05-11T06:52:23Z
dc.date.available2024-02-01T00:00:07Z
dc.date.issued2023
dc.date.updated2023-05-11T06:46:26Z
dc.description.abstractSchizophrenia is frequently characterized by the presence of multiple relapses. Cognitive impairments are core features of schizophrenia. Cognitive reserve (CR) is the ability of the brain to compensate for damage caused by pathologies such as psychotic illness. As cognition is related to CR, the study of the relationship between relapse, cognition and CR may broaden our understanding of the course of the disease. We aimed to determine whether relapse was associated with cognitive impairment, controlling for the effects of CR. Ninety-nine patients with a remitted first episode of schizophrenia or schizophreniform disorder were administered a set of neuropsychological tests to assess premorbid IQ, attention, processing speed, working memory, verbal and visual memory, executive functions and social cognition. They were followed up for 3 years (n=53) or until they relapsed (n=46). Personal and familial CR was estimated from a principal component analysis of the premorbid information gathered. Linear mixed-effects models were applied to analyse the effect of time and relapse on cognitive function, with CR as covariate. Patients who relapsed and had higher personal CR showed less deterioration in attention, whereas those with higher CR (personal and familial CR) who did not relapse showed better performance in processing speed and visual memory. Taken together, CR seems to ameliorate the negative effects of relapse on attention performance and shows a positive effect on processing speed and visual memory in those patients who did not relapse. Our results add evidence for the protective effect of CR over the course of the illness.en
dc.description.sponsorshipR. Rodriguez-Jimenez was supported by the Instituto de Salud Carlos III (PI19/00766; Fondo de Investigaciones Sanitarias/FEDER) and of Madrid Regional Government (S2017/BMD-3740)en
dc.embargo.lift2024-02-01
dc.embargo.terms2024-02-01
dc.format.mimetypeapplication/pdfen
dc.identifier.citationSánchez-Torres, A. M., Amoretti, S., Enguita-Germán, M., Mezquida, G., Moreno-Izco, L., Panadero-Gómez, R., Rementería, L., Toll, A., Rodriguez-Jimenez, R., Roldán, A., Pomarol-Clotet, E., Ibáñez, Á., Usall, J., Contreras, F., Vieta, E., López-Ilundain, J. M., Merchán-Naranjo, J., González-Pinto, A., Berrocoso, E., Bernardo, M., Cuesta, M. J., Forte, M. F., González-Díaz, J. M., Parellada, M., Abrokwa, H., Segura, M. S., González, J. S., Zorrilla, I., González-Ortega, I., Legido, T., Mané, A., Sanchez-Pastor, L., Rentero, D., Sarró, S., García-León, M. Á., Butjosa, A., Pardo, M., Zarzuela, A., Ribeiro, M., Saiz-Ruiz, J., León-Quismondo, L., Hernández, M., de la Cámara, C., Gutiérrez-Fraile, M., González-Blanco, L. (2023) Relapse, cognitive reserve and their relationship with cognition in first episode schizophrenia: a 3-year follow-up study. European Neuropsychopharmacology, 67, 53-65. https://doi.org/10.1016/j.euroneuro.2022.11.011.en
dc.identifier.doi10.1016/j.euroneuro.2022.11.011
dc.identifier.issn0924-977X
dc.identifier.urihttps://academica-e.unavarra.es/handle/2454/45284
dc.language.isoengen
dc.publisherElsevieren
dc.relation.ispartofEuropean Neuropsychopharmacology, 67 (2023) 53-65en
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI19%2F00766/ES/en
dc.relation.publisherversionhttps://doi.org/10.1016/j.euroneuro.2022.11.011
dc.rights© 2022 Elsevier B.V. and ECNP. This manuscript version is made available under the CC-BY-NC-ND 4.0en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCognitionen
dc.subjectCognitive reserveen
dc.subjectRelapseen
dc.subjectSchizophreniaen
dc.titleRelapse, cognitive reserve and their relationship with cognition in first episode schizophrenia: a 3-year follow-up studyen
dc.typeinfo:eu-repo/semantics/article
dc.type.versionVersión aceptada / Onetsi den bertsioaes
dc.type.versioninfo:eu-repo/semantics/acceptedVersionen
dspace.entity.typePublication
relation.isAuthorOfPublication6cfdb372-fb89-4760-b1b8-404b0f0ae941
relation.isAuthorOfPublicationea88491f-9642-4b5b-b1d7-02987d63fc1b
relation.isAuthorOfPublicationc60095c1-5436-4633-9b1c-f7d8a73c0e32
relation.isAuthorOfPublication.latestForDiscovery6cfdb372-fb89-4760-b1b8-404b0f0ae941

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