The dietary inflammatory index and hepatic health in the US adult population

Ramírez Vélez, Robinson; García Hermoso, Antonio; Izquierdo Redín, Mikel; Correa Rodríguez, María

Publication:
The dietary inflammatory index and hepatic health in the US adult population

dc.contributor.author	Ramírez Vélez, Robinson
dc.contributor.author	García Hermoso, Antonio
dc.contributor.author	Izquierdo Redín, Mikel
dc.contributor.author	Correa Rodríguez, María
dc.contributor.department	Ciencias de la Salud	es_ES
dc.contributor.department	Osasun Zientziak	eu
dc.date.accessioned	2022-06-09T12:23:29Z
dc.date.available	2022-06-09T12:23:29Z
dc.date.issued	2021
dc.date.updated	2022-06-09T12:21:57Z
dc.description.abstract	Background: There is limited evidence on the role of an anti‐/pro‐inflammatory diet in the prevention of non‐alcoholic fatty liver disease (NAFLD). We aimed (i) to assess the anti‐inflammatory diet profile and its association with transient elastography parameters, including liver stiffness measurement (LSM) and controlled attenuation parameter (CAP), and (ii) to analyse the relationship between the anti‐inflammatory diet and surrogate markers of liver disease in a multiethnic US population. Methods: A cross‐sectional study was conducted on a nationally representative population of 4189 US adults aged 20–80 years. A FibroScan® 502 V2 device (Echosens) was used to estimate the CAP and LSM. Liver markers, including the aspartate transaminase (AST) to alanine transaminase (ALT) ratio, fatty liver index (FLI) and fibrosis‐4 score, were also calculated. The Dietary Inflammatory Index (DII) was calculated using a 24‐h diet recall. Results: Lower DII scores (anti‐inflammatory diet) were associated with a lower AST:ALT ratio (p < 0.001) and FLI (p < 0.036) after adjusting for covariates. Linear regression analysis revealed that gamma‐glutamyl transferase levels (β = 1.702, 95% confidence interval [CI] = 0.325–3.080, p = 0.015), ALT levels (β = −0.616, 95% CI = −1.097 to −0.135, p = 0.012), AST:ALT ratio (β = 0.025, 95% CI = 0.014–0.036, p < 0.001) and FLI (β = 1.168, 95% CI = 0.224–2.112, p = 0.015) were significantly associated with the DII in the multivariable‐adjusted model. Participants in the highest anti‐inflammatory tertile had the lowest odds ratio (OR) for NAFLD assessed by FLI in both unadjusted (OR = 0.652, 95% CI = 0.539–0.788, p ≤ 0.001) and adjusted models (OR = 0.722, 95% CI = 0.537–0.972, p = 0.032). For the transient elastography parameters (LSM and CAP), no significant associations were identified. Conclusions: There was no relationship between the transient elastography parameters and the anti‐inflammatory diet profile, although our study showed an association between higher pro‐inflammatory properties of diet and poorer hepatic health assessed by surrogate markers of liver disease. Therefore, strategies to promote an anti‐inflammatory diet should be considered to prevent NAFLD in adults.	en
dc.description.sponsorship	Funding for open access charge, Universidad de Granada/CBUA	es_ES
dc.format.extent	12 p.
dc.format.mimetype	application/pdf	en
dc.identifier.citation	Ramírez‐Vélez R, García‐Hermoso A, Izquierdo M, Correa‐Rodríguez M. The Dietary Inflammatory Index and hepatic health in the US adult population. J Hum Nutr Diet. 2021;1–12	es
dc.identifier.doi	10.1111/jhn.12962
dc.identifier.issn	1365-277X
dc.identifier.uri	https://academica-e.unavarra.es/handle/2454/43089
dc.language.iso	spa	en
dc.publisher	The British Dietetic Association Ltd	en
dc.relation.ispartof	Journal of Human Nutrition and Dietetics, 2021, 1-12	en
dc.relation.publisherversion	https://doi.org/10.1111/jhn.12962
dc.rights	This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited	en
dc.rights.accessRights	info:eu-repo/semantics/openAccess	en
dc.rights.accessRights	Acceso abierto / Sarbide irekia	es
dc.subject	Anti-inflammatory diet	en
dc.subject	Diet	en
dc.subject	Inflammation	en
dc.subject	Liver	en
dc.subject	Non-alcoholic fatty liver disease	en
dc.title	The dietary inflammatory index and hepatic health in the US adult population	en
dc.type	info:eu-repo/semantics/article	en
dc.type	Artículo / Artikulua	es
dc.type.version	info:eu-repo/semantics/publishedVersion	en
dc.type.version	Versión publicada / Argitaratu den bertsioa	es
dspace.entity.type	Publication
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