Nontypable haemophilus influenzae displays a prevalent surface structure molecular pattern in clinical isolates
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Fecha
2011Autor
Versión
Acceso abierto / Sarbide irekia
Tipo
Artículo / Artikulua
Versión
Versión publicada / Argitaratu den bertsioa
Impacto
|
10.1371/journal.pone.0021133
Resumen
Non-typable Haemophilus influenzae (NTHi) is a Gram negative pathogen that causes acute respiratory infections and is associated with the progression of chronic respiratory diseases. Previous studies have established the existence of a remarkable genetic variability among NTHi strains. In this study we show that, in spite of a high level of genetic heterogeneity, NTHi clinical isolates display ...
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Non-typable Haemophilus influenzae (NTHi) is a Gram negative pathogen that causes acute respiratory infections and is associated with the progression of chronic respiratory diseases. Previous studies have established the existence of a remarkable genetic variability among NTHi strains. In this study we show that, in spite of a high level of genetic heterogeneity, NTHi clinical isolates display a prevalent molecular feature, which could confer fitness during infectious processes. A total of 111 non-isogenic NTHi strains from an identical number of patients, isolated in two distinct geographical locations in the same period of time, were used to analyse nine genes encoding bacterial surface molecules, and revealed the existence of one highly prevalent molecular pattern (lgtF+, lic2A+, lic1D+, lic3A+, lic3B+, siaA-, lic2C+, ompP5+, oapA+) displayed by 94.6% of isolates. Such a genetic profile was associated with a higher bacterial resistance to serum mediated killing and enhanced adherence to human respiratory epithelial cells. [--]
Materias
Outer membrane protein,
C reactive protein,
Epithelial cells,
Otitis media,
Phase variation,
Biofilm communities,
Serum resistance,
Sialic acid,
Middle ear,
Inner core
Editor
Public Library of Science
Publicado en
Plos One, 2011, 6(6): e21133
Departamento
Universidad Pública de Navarra/Nafarroako Unibertsitate Publikoa. IdAB. Instituto de Agrobiotecnología / Agrobioteknologiako Institutua
Versión del editor
Entidades Financiadoras
This work was supported by grants from Instituto de Salud Carlos III (ISCIII, Spain) with references CP05-0027, PI06-1251 and PS09-0130, and from Fundación Mutua Madrileña 2008 to JG, and by a grant from Instituto de Salud Carlos III (ISCIII, Spain) with reference PS09-1904 to JL.
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La licencia del ítem se describe como © 2011 Martí–Lliteras et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.