Rosa canina extracts have antiproliferative and antioxidant effects on caco-2 human colon cancer

Jiménez Alonso, Sandra; Gascón, Sonia; Luquin, Asunción; Laguna, Mariano; Ancín Azpilicueta, Carmen; Rodríguez Yoldi, María Jesús

doi:10.1371/journal.pone.0159136

dc.creator	Jiménez Alonso, Sandra	es_ES
dc.creator	Gascón, Sonia	es_ES
dc.creator	Luquin, Asunción	es_ES
dc.creator	Laguna, Mariano	es_ES
dc.creator	Ancín Azpilicueta, Carmen	es_ES
dc.creator	Rodríguez Yoldi, María Jesús	es_ES
dc.date.accessioned	2018-09-06T12:20:23Z
dc.date.available	2018-09-06T12:20:23Z
dc.date.issued	2016
dc.identifier.issn	1932-6203
dc.identifier.uri	https://hdl.handle.net/2454/30557
dc.description.abstract	The in vitro antiproliferative and antioxidant effects of different fractions of Rosa canina hips on human colon cancer cell lines (Caco-2) was studied. The compounds tested were total extract (fraction 1), vitamin C (fraction 2), neutral polyphenols (fraction 3) and acidic polyphenols (fraction 4). All the extracts showed high cytotoxicity after 72 h, both low and high concentrations. The flow cytometric analysis revealed that all the fractions produce disturbances in the cell cycle resulting in a concomitant cell death by an apoptotic pathway. Changes in the redox status of Caco-2 cells in response to Rosa canina hips were determined. Cells were exposed to hydrogen peroxide in presence of plant fractions and the production of Reactive Oxygen Species (ROS) was significantly decreased. Therefore, our data demonstrate that rosehip extracts are a powerful antioxidant that produces an antiproliferative effect in Caco-2 cells. Therefore, these results predict a promising future for Rosa canina as a therapeutic agent. Thus, this natural plant could be an effective component of functional foods addressed towards colorectal carcinoma.	en
dc.description.sponsorship	This study was supported by the projects: the Ministry of Science and Innovation (SAF2013-41651), funding from Aragón Regional Government (A-32) and CIBER (Centros de Investigación Biomédica en Red) Sub-program (CIBERobn, CB06/03/1012,) by the Instituto de Salud Carlos III and Proyecto ELENA, EFA 220/11 ELENA.	en
dc.format.mimetype	application/pdf	en
dc.format.mimetype	application/zip	en
dc.language.iso	eng	en
dc.publisher	Public Library of Science	en
dc.relation.ispartof	Plos One, 11(7): e0159136	en
dc.rights	© 2016 Jiménez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.	en
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/
dc.subject	Rosa canina hips	en
dc.subject	Colon cancer	en
dc.subject	Caco-2 cells	en
dc.subject	Antiproliferative effect	en
dc.subject	Antioxidant effect	en
dc.title	Rosa canina extracts have antiproliferative and antioxidant effects on caco-2 human colon cancer	en
dc.type	info:eu-repo/semantics/article	en
dc.type	Artículo / Artikulua	es
dc.contributor.department	Química Aplicada	es_ES
dc.contributor.department	Kimika Aplikatua	eu
dc.rights.accessRights	info:eu-repo/semantics/openAccess	en
dc.rights.accessRights	Acceso abierto / Sarbide irekia	es
dc.identifier.doi	10.1371/journal.pone.0159136
dc.relation.projectID	info:eu-repo/grantAgreement/MINECO//SAF2013-41651-R/ES/	en
dc.relation.publisherversion	https://doi.org/10.1371/journal.pone.0159136
dc.type.version	info:eu-repo/semantics/publishedVersion	en
dc.type.version	Versión publicada / Argitaratu den bertsioa	es

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© 2016 Jiménez et al. This is an open
access article distributed under the terms of the
Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any
medium, provided the original author and source are
credited.

La licencia del ítem se describe como © 2016 Jiménez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.