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PD-L1 expression in systemic immune cell populations as a potential predictive biomarker of responses to PD-L1/PD-1 blockade therapy in lung cancer
dc.creator | Bocanegra Gondán, Ana Isabel | es_ES |
dc.creator | Fernandez Hinojal, Gonzalo | es_ES |
dc.creator | Zuazo Ibarra, Miren | es_ES |
dc.creator | Arasanz Esteban, Hugo | es_ES |
dc.creator | Garcia-Granda, María Jesús | es_ES |
dc.creator | Hernandez, Carlos | es_ES |
dc.creator | Ibáñez-Vea, María | es_ES |
dc.creator | Hernandez-Marin, Berta | es_ES |
dc.creator | Martinez-Aguillo, Maite | es_ES |
dc.creator | Lecumberri, María José | es_ES |
dc.creator | Fernández de Lascoiti, Ángela | es_ES |
dc.creator | Teijeira, Lucía | es_ES |
dc.creator | Morilla Ruiz, Idoia | es_ES |
dc.creator | Vera García, Ruth | es_ES |
dc.creator | Escors Murugarren, David | es_ES |
dc.creator | Kochan, Grazyna | es_ES |
dc.date.accessioned | 2022-08-08T11:08:29Z | |
dc.date.available | 2022-08-08T11:08:29Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Bocanegra, A.; Fernandez-Hinojal, G.; Zuazo-Ibarra, M.; Arasanz, H.; Garcia-Granda, M.J.; Hernandez, C.; Ibañez, M.; Hernandez-Marin, B.; Martinez-Aguillo, M.; Lecumberri, M.J.; Fernandez de Lascoiti, A., Teijeira, L., Morilla, I., Vera, R.; Escors, D.; Kochan, G.. (2019). PD-L1 Expression in Systemic Immune Cell Populations as a Potential Predictive Biomarker of Responses to PD-L1/PD-1 Blockade Therapy in Lung Cancer. International Journal of Molecular Sciences. 20,7. | en |
dc.identifier.issn | 1661-6596 | |
dc.identifier.uri | https://hdl.handle.net/2454/43707 | |
dc.description.abstract | PD-L1 tumor expression is a widely used biomarker for patient stratification in PD-L1/PD-1 blockade anticancer therapies, particularly for lung cancer. However, the reliability of this marker is still under debate. Moreover, PD-L1 is widely expressed by many immune cell types, and little is known on the relevance of systemic PD-L1+ cells for responses to immune checkpoint blockade. We present two clinical cases of patients with non-small cell lung cancer (NSCLC) and PD-L1-negative tumors treated with atezolizumab that showed either objective responses or progression. These patients showed major differences in the distribution of PD-L1 expression within systemic immune cells. Based on these results, an exploratory study was carried out with 32 cases of NSCLC patients undergoing PD-L1/PD-1 blockade therapies, to compare PD-L1 expression profiles and their relationships with clinical outcomes. Significant differences in the percentage of PD-L1+ CD11b+ myeloid cell populations were found between objective responders and non-responders. Patients with percentages of PD-L1+ CD11b+ cells above 30% before the start of immunotherapy showed response rates of 50%, and 70% when combined with memory CD4 T cell profiling. These findings indicate that quantification of systemic PD-L1+ myeloid cell subsets could provide a simple biomarker for patient stratification, even if biopsies are scored as PD-L1 null | en |
dc.description.sponsorship | This research was funded by Asociación Española Contra el Cáncer, grant number AECC PROYE16001ESCO; Instituto de Salud Carlos III, Spain, grant number FIS grant PI17/02119; and a 'Precipita' Crowdfunding grant (FECYT), no grant number. M.Z.-I. is supported by a scholarship from Universidad Pública de Navarra; H.A. is supported by a scholarship from AECC. C.H.S. is supported by a Roche fellowship 'Stop fuga de cerebros'. | en |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | en |
dc.publisher | MDPI | en |
dc.relation.ispartof | International Journal of Molecular Sciences, 2019, 20 (7),1631 | en |
dc.rights | © 2022 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject | PD-L1 | en |
dc.subject | Biomarker | en |
dc.subject | Lung cancer | en |
dc.subject | Immunotherapy | en |
dc.subject | Immune checkpoint blockade | en |
dc.title | PD-L1 expression in systemic immune cell populations as a potential predictive biomarker of responses to PD-L1/PD-1 blockade therapy in lung cancer | en |
dc.type | Artículo / Artikulua | es |
dc.type | info:eu-repo/semantics/article | en |
dc.date.updated | 2022-08-08T11:05:11Z | |
dc.contributor.department | Ciencias de la Salud | es_ES |
dc.contributor.department | Osasun Zientziak | eu |
dc.rights.accessRights | Acceso abierto / Sarbide irekia | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | en |
dc.identifier.doi | 10.3390/ijms20071631 | |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI17%2F02119/ES/ | en |
dc.relation.publisherversion | https://doi.org/10.3390/ijms20071631 | |
dc.type.version | Versión publicada / Argitaratu den bertsioa | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dc.contributor.funder | Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa | es |