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Plasma inflammatory biomarkers and anorexia of ageing among community-dwelling older adults: an exploratory analysis of the MAPT Study
dc.creator | Sánchez Sánchez, Juan Luis | es_ES |
dc.creator | Guyonnet, Sophie | es_ES |
dc.creator | Lucas, Alexandre | es_ES |
dc.creator | Parini, Angelo | es_ES |
dc.creator | Rolland, Y. | es_ES |
dc.creator | Souto Barreto, Philipe de | es_ES |
dc.date.accessioned | 2024-05-08T15:19:32Z | |
dc.date.available | 2024-05-08T15:19:32Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Sánchez-Sánchez, J. L., Guyonnet, S., Lucas, A., Parini, A., Rolland, Y., & De Souto Barreto, P. (2023). Plasma inflammatory biomarkers and anorexia of ageing among community-dwelling older adults: An exploratory analysis of the mapt study. The Journal of Nutrition, Health and Aging, 27(11), 1127-1131. https://doi.org/10.1007/s12603-023-2024-8 | en |
dc.identifier.issn | 1279-7707 | |
dc.identifier.uri | https://hdl.handle.net/2454/48081 | |
dc.description.abstract | Anorexia of aging and biological aging might share physiological underpinnings. The aim of this secondary analysis was to investigate the associations between circulating inflammation-related markers and anorexia of aging in community-dwelling older adults. C-reactive protein (CRP), tumor necrosis factor receptor-1 (TNFR-1), interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1) and growth/differentiation factor-15 (GDF-15) were measured in plasma. Anorexia of aging was defined by the response “severe/moderate decrease in food intake” to the first item of the Mini-Nutritional Assessment. We included 463 subjects (median age=74y, IQR=71–78; 63.1% women). 33 subjects (7.1%) presented with anorexia at baseline, whereas 25 out of 363 (6.9%) developed it along 1-year follow-up. We found that TNFR1 (OR=1.74, 95%CI=1.27–2.39) and GDF-15 (OR=1.38, 95%CI=1.01–1.89) were associated with a significant increase in the odds of presenting with anorexia of aging cross-sectionally. No further significant associations were found. Biological aging mechanisms might be involved in the pathogenesis of anorexia of aging. | en |
dc.format.mimetype | application/pdf | en |
dc.format.mimetype | application/msword | en |
dc.language.iso | eng | en |
dc.publisher | Springer | en |
dc.relation.ispartof | The Journal of Nutrition, Health and Aging 27(11), 2023, 1127-1131 | en |
dc.rights | © Serdi and Springer-Verlag International SAS, part of Springer Nature, 2023. CC BY-NC-ND 4.0 Attribution-NonCommercial-NoDerivs 4.0 International. | en |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject | Anorexia of aging | en |
dc.subject | Biomarkers | en |
dc.subject | Inflammation | en |
dc.subject | Malnutrition | en |
dc.title | Plasma inflammatory biomarkers and anorexia of ageing among community-dwelling older adults: an exploratory analysis of the MAPT Study | en |
dc.type | Artículo / Artikulua | es |
dc.type | info:eu-repo/semantics/article | en |
dc.date.updated | 2024-05-08T14:54:08Z | |
dc.contributor.department | Ciencias de la Salud | es_ES |
dc.contributor.department | Osasun Zientziak | eu |
dc.rights.accessRights | Acceso abierto / Sarbide irekia | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | en |
dc.identifier.doi | 10.1007/s12603-023-2024-8 | |
dc.relation.publisherversion | https://doi.org/10.1007/s12603-023-2024-8 | |
dc.type.version | Versión publicada / Argitaratu den bertsioa | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |