Celay Leoz, IonBlanco Luquin, IdoiaLázcoz Ripoll, PaulaRotinen Díaz, Mirja SofiaCastresana, Javier S.Encío Martínez, Ignacio2018-09-062018-09-0620131932-620310.1371/journal.pone.0062771https://academica-e.unavarra.es/handle/2454/30552To determine the effect of retinoic acid (RA) in neuroblastoma we treated RA sensitive neuroblastoma cell lines with 9-cis RA or ATRA for 9 days, or for 5 days followed by absence of RA for another 4 days. Both isomers induced apoptosis and reduced cell density as a result of cell differentiation and/or apoptosis. Flow cytometry revealed that 9-cis RA induced apoptosis more effectively than ATRA. The expression profile of apoptosis and survival pathways was cell line specific and depended on the isomer used.application/pdfeng© 2013 Celay et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Retinoic acidNeuroblastomaApoptosisinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccess