Ubago Guisado, EstherGracia-Marco, LuisMedrano Echeverría, MaríaCadenas-Sánchez, CristinaArenaza Etxeberría, LideMigueles, Jairo H.Mora González, JoséTobalina, IgnacioEscolano Margarit, María VictoriaOsés Recalde, MaddiMartín Matillas, MiguelLabayen Goñi, IdoiaOrtega, Francisco B.2020-05-262020-05-2620190031-399810.1038/s41390-019-0708-xhttps://academica-e.unavarra.es/handle/2454/36986Objectives: To examine whether areal bone mineral density (aBMD) differs between metabolically healthy (MHO) and unhealthy (MUO) overweight/obese children and to examine the role of moderate-to-vigorous physical activity (MVPA) and cardiorespiratory fitness (CRF) in this association. Methods: A cross-sectional study was developed in 188 overweight/obese children (10.4 ± 1.2 years) from the ActiveBrains and EFIGRO studies. Participants were classified as MHO or MUO based on Jolliffe and Janssen’s metabolic syndrome cut-off points for triglycerides, glucose, high-density cholesterol and blood pressure. MVPA and CRF were assessed by accelerometry and the 20-m shuttle run test, respectively. Body composition was measured by dual-energy X-ray absorptiometry. Results: In model 1 (adjusted for sex, years from peak high velocity, stature and lean mass), MHO children had significantly higher aBMD in total body less head (Cohen’s d effect size, ES = 0.34), trunk (ES = 0.43) and pelvis (ES = 0.33) than MUO children. These differences were attenuated once MVPA was added to model 1 (model 2), and most of them disappeared once CRF was added to the model 1 (model 3). Conclusions: This novel research shows that MHO children have greater aBMD than their MUO peers. Furthermore, both MVPA and more importantly CRF seem to partially explain these findings.22 p.application/pdfapplication/zipeng© 2019, Springer NatureAreal bone mineral densityObesityChildrenPhysical activityCardiorespiratory fitnessinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccess