Saz-Lara, AliciaCavero-Redondo, IvánMoreno-Herráiz, NereaRescalvo-Fernández, ElenaBerlanga-Macías, CarlosMedrano Echeverría, MaríaFuentes Chacón, Rosa MaríaPascual-Morena, Carlos2025-02-202024-10-28Saz-Lara, A., Cavero-Redondo, I., Moreno-Herráiz, N., Rescalvo-Fernández, E., Berlanga-Macías, C., Medrano, M., Fuentes Chacón, R. M., Pascual-Morena, C. (2024). Association between body shape index and arterial stiffness: results of the EVasCu study and a meta-analysis. International Journal of Obesity. 49, 554-563. https://doi.org/10.1038/s41366-024-01663-80307-056510.1038/s41366-024-01663-8https://academica-e.unavarra.es/handle/2454/53508Objective: The aim of this study was to analyse the association between body shape index (ABSI) and arterial stiffness in healthy subjects using data from the EVasCu study. In addition, a meta-analysis was performed to compare the association between ABSI and central, peripheral and systemic arterial stiffness in the general population. Methods: The EVasCu study included 390 healthy subjects. ABSI was calculated from waist circumference, body mass index and height, and arterial stiffness was assessed with aortic pulse wave velocity (a-PWv) and cardio-ankle vascular index (CAVI). A meta-analysis of previous studies, including data from the EVasCu study, was performed to obtain pooled estimates of correlation coefficients (r) and their respective 95% confidence intervals (95% CIs) for the association between ABSI and central, peripheral and systemic arterial stiffness. In addition, pooled OR estimates and their 95% CIs were calculated. Results: In the EVasCu study, the correlation coefficient estimate was 0.458 (p < 0.01) for the association of a-PWv and ABSI and 0.408 (p < 0.01) for the association of CAVI and ABSI. In the meta-analysis, the pooled correlation coefficient estimate was 0.22 (95% CIs: 0.16, 0.28) for central arterial stiffness and ABSI, 0.21 (95% CIs: 0.14, 0.28) for peripheral arterial stiffness and ABSI, and 0.28 (95% CI: 0.21, 0.3) for systemic arterial stiffness and ABSI. When pooled ORs were calculated, the pooled OR estimate was 2.12 (95% CIs: 1.68, 2.56) for central arterial stiffness and ABSI, 2.21 (95% CIs: 1.81, 2.60) for peripheral arterial stiffness and ABSI, and 2.99 (95% CIs: 2.14, 3.85) for systemic arterial stiffness and ABSI. Conclusion: Based on both the results obtained in the EVasCu study and the meta-analysis, there is a positive association between ABSI and arterial stiffness, both in healthy subjects and in participants with comorbidities. For each unit of cm/kg/m²/m increase in ABSI, the risk of arterial stiffness increased by 112% for central arterial stiffness, 121% for peripheral arterial stiffness, and 199% for systemic arterial stiffness. However, further research is needed in this field of knowledge.application/pdfeng© 2024, The Author(s), under exclusive licence to Springer Nature LimitedBody shape indexArterial stiffnessPulse wave velocityCardio-ankle vascular indexAdult populationinfo:eu-repo/semantics/article2025-02-20info:eu-repo/semantics/openAccess