Arasanz Esteban, HugoGato Cañas, MaríaZuazo Ibarra, MirenIbañez Vea, MaríaBreckpot, KarineKochan, GrazynaEscors Murugarren, David2022-08-082022-08-082017Arasanz, H.; Gato-Cañas, M.; Zuazo, M.; Ibáñez-Vea, M.; Breckpot, K.; Kochan, G.; Escors, D.. (2017). PD1 signal transduction pathways in T cells. Oncotarget. 8,31, pp. 51936-519451949-255310.18632/oncotargethttps://academica-e.unavarra.es/handle/2454/43708The use of immune checkpoint inhibitors for the treatment of cancer is revolutionizing oncology. Amongst these therapeutic agents, antibodies that block PD-L1/PD1 interactions between cancer cells and T cells are demonstrating high efficacies and low toxicities. Despite all the recent advances, very little is yet known on the molecular intracellular signaling pathways regulated by either PD-L1 or PD1. Here we review the current knowledge on PD1-dependent intracellular signaling pathways, and the consequences of disrupting PD1 signal transduction.application/pdfeng© Arasanz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0PD-L1PDL1PD1B7-H1Cancerinfo:eu-repo/semantics/article2022-08-08info:eu-repo/semantics/openAccess