Rivero Fuente, Pedro J.Urrutia Azcona, AitorGoicoechea Fernández, JavierRodríguez, YoanyCorres Sanz, Jesús MaríaArregui San Martín, Francisco JavierMatías Maestro, Ignacio2024-08-082024-08-082012Rivero P.J., Urrutia A., Goicoechea J., Rodriguez Y., Corres J.M., Arregui F.J., Matias I.R. (2012) An antibacterial submicron fiber mat with in situ synthesized silver nanoparticles. Journal of Applied Polymer Science, 126(4), 1228-1235. https://doi.org/10.1002/app.36886.0021-899510.1002/app.36886https://academica-e.unavarra.es/handle/2454/50634This work presents an alternative approachfor fabricating electrospun submicron highly hydrophilicfiber mats loaded with silver nanoparticles. These fiber matsshow a high efficient antibacterial behavior, very attractivefor applications like wound healing and skin regenerationprocesses. The fabrication method is divided in two steps.First, poly(acrylic acid) (PAA) and b-cyclodextrin (b-CD)submicron fibers were electrospun and further stabilizedusing a thermal treatment, yielding stable hydrogel-likefibers with diameters ranging from 100 nm up to severalmicrons. In the second step, silver ions were loaded into thefibers and then reduced to silver nanoparticles in-situ. Theelectrospinning parameters were adjusted to achieve thedesired properties of the fiber mat (density, size) and after-wards, the characteristics of the silver nanoparticles(amount, size, aggregation) were tuned by controlling thesilver ion loading mechanism. Highly biocide surfaces wereachieved showing more than 99.99% of killing efficiency.The two-step process improves the reproducibility and tun-ability of the fiber mats. To our knowledge, this is the firsttime that stable hydrogel fibers with a highly biocide behav-ior have been fabricated using electrospinning.application/pdfeng© 2012 Wiley Periodicals, Inc.AntibacterialSubmicron fiber matSilver nanoparticlesinfo:eu-repo/semantics/article2024-08-08info:eu-repo/semantics/openAccess