Garrido Ruiz, Patricia AlejandraGonzález-Tablas, MaríaPasco Peña, AlejandroZelaya Huerta, María VictoriaOrtiz, JavierOtero, ÁlvaroCorchete, Luis AntonioLudeña, María DoloresCaballero Martínez, María CristinaCórdoba Iturriagagoitia, AliciaFernández, Inmaculada CatalinaGonzález-Carreró Fojón, JoaquínHernández Laín, AurelioOrfao, AlbertoTabernero, María Dolores2023-05-052023-05-052023Garrido Ruiz, P. A., González-Tablas, M., Pasco Peña, A., Zelaya Huerta, M. V., Ortiz, J., Otero, Á., Corchete, L. A., Ludeña, M. D., Caballero Martínez, M. C., Córdoba Iturriagagoitia, A., Fernández, I. C., González-Carreró Fojón, J., Hernández Laín, A., Orfao, A., & Tabernero, M. D. (2023). Clinical, histopathologic and genetic features of rhabdoid meningiomas. International Journal of Molecular Sciences, 24(2), 1116. https://doi.org/10.3390/ijms240211161661-659610.3390/ijms24021116https://academica-e.unavarra.es/handle/2454/45244Rhabdoid meningiomas (RM) shows heterogeneous histological findings, and a wide variety of chromosomal copy number alterations (CNA) are associated with an unpredictable course of the disease. In this study, we analyzed a series of 305 RM samples from patients previously reported in the literature and 33 samples from 23 patients studied in our laboratory. Monosomy 22-involving the minimal but most common recurrent region loss of the 22q11.23 chromosomal region was the most observed chromosomal alteration, followed by losses of chromosomes 14, 1, 6, and 19, polysomies of chromosomes 17, 1q, and 20, and gains of 13q14.2, 10p13, and 21q21.2 chromosomal regions. Based on their CNA profile, RM could be classified into two genetic subgroups with distinct clinicopathologic features characterized by the presence of (1) chromosomal losses only and (2) combined losses and gains of several chromosomes. The latter displays a higher frequency of WHO grade 3 tumors and poorer clinical outcomes.application/pdfapplication/zipeng© 2023 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.Chromosome copy number alterationsDiagnosisHistopathologyPrognosisRhabdoid meningiomaSurvivalArtículo / Artikulua2023-05-05Acceso abierto / Sarbide irekiainfo:eu-repo/semantics/openAccess