García Rodríguez, LucíaGarayo Urabayen, EnekoLópez Ortega, AlbertoGalarreta Rodríguez, ItziarCervera Gabalda, Laura MaríaCruz Quesada, GuillermoCornejo Ibergallartu, AlfonsoGarrido Segovia, Julián JoséGómez Polo, CristinaPérez de Landazábal Berganzo, José Ignacio2025-01-272025-01-272022-12-23García, L., Garaio, E., López-Ortega, A., Galarreta-Rodriguez, I., Cervera-Gabalda, L., Cruz-Quesada, G., Cornejo, A., Garrido, J. J., Gómez-Polo, C., Pérez-Landazábal, J. I. (2023). Fe3O4-SiO2 mesoporous core/shell nanoparticles for magnetic field-induced ibuprofen-controlled release. Langmuir, 31(1), 211-219. https://doi.org/10.1021/acs.langmuir.2c02408.0743-746310.1021/acs.langmuir.2c02408https://academica-e.unavarra.es/handle/2454/53095Hybrid magnetic nanoparticles made up of an iron oxide, Fe3O4, core and a mesoporous SiO2 shell with high magnetization and a large surface area were proposed as an efficient drug delivery platform. The core/shell structure was synthesized by two seed-mediated growth steps combining solvothermal and sol—gel approaches and using organic molecules as a porous scaffolding template. The system presents a mean particle diameter of 30(5) nm (9 nm magnetic core diameter and 10 nm silica shell thickness) with superparamagnetic behavior, saturation magnetization of 32 emu/g, and a significant AC magnetic-field-induced heating response (SAR = 63 W/gFe3O4, measured at an amplitude of 400 Oe and a frequency of 307 kHz). Using ibuprofen as a model drug, the specific surface area (231 m2/g) of the porous structure exhibits a high molecule loading capacity (10 wt %), and controlled drug release efficiency (67%) can be achieved using the external AC magnetic field for short time periods (5 min), showing faster and higher drug desorption compared to that of similar stimulus-responsive iron oxide-based nanocarriers. In addition, it is demonstrated that the magnetic field-induced drug release shows higher efficiency compared to that of the sustained release at fixed temperatures (47 and 53% for 37 and 42 °C, respectively), considering that the maximum temperature reached during the exposure to the magnetic field is well below (31 °C). Therefore, it can be hypothesized that short periods of exposure to the oscillating field induce much greater heating within the nanoparticles than in the external solution.application/pdfeng© 2022 American Chemical Society.Drug releaseHyperthermiaMagnetic propertiesNanoparticlesSilicainfo:eu-repo/semantics/article2025-01-27info:eu-repo/semantics/openAccess