Lorea Revilla, BeñatGarcía-Urricelqui, AneOdriozola Ibarguren, José ManuelRazkin Lizarraga, JesúsEspinal Viguri, MaialenOiarbide, MikelMielgo, AntoniaGarcía Castillo, Jesús MaríaPalomo, Claudio2024-01-082024-01-082023Lorea, B., García-Urricelqui, A., Odriozola, J. M., Razkin, J., Espinal-Viguri, M., Oiarbide, M., Mielgo, A., García, J. M., & Palomo, C. (2023). Organocatalytic michael addition of unactivated α-branched nitroalkanes to afford optically active tertiary nitrocompounds. Organic Letters, 25(48), 8590-8595. https://doi.org/10.1021/acs.orglett.3c033401523-706010.1021/acs.orglett.3c03340https://academica-e.unavarra.es/handle/2454/46968The direct, asymmetric conjugate addition of unactivated ¿-branched nitroalkanes is developed based on the combined use of chiral amine/ureidoaminal bifunctional catalysts and a tunable acrylate template to provide tertiary nitrocompounds in 55¿80% isolated yields and high enantioselectivity (e.r. up to 96:4). Elaboration of the ketol moiety in thus obtained adducts allows a fast entry to not only carboxylic and aldehyde derivatives but also nitrile compounds and enantioenriched 5,5-disubstituted ¿-lactams.application/pdfeng© 2023 The Authors. This article is licensed under CC-BY 4.0.Artículo / Artikulua2024-01-08Acceso abierto / Sarbide irekiainfo:eu-repo/semantics/openAccess