Sánchez Sánchez, Juan LuisGuyonnet, SophieLucas, AlexandreParini, AngeloRolland, Y.Souto Barreto, Philipe de2024-05-082024-05-082023Sánchez-Sánchez, J. L., Guyonnet, S., Lucas, A., Parini, A., Rolland, Y., & De Souto Barreto, P. (2023). Plasma inflammatory biomarkers and anorexia of ageing among community-dwelling older adults: An exploratory analysis of the mapt study. The Journal of Nutrition, Health and Aging, 27(11), 1127-1131. https://doi.org/10.1007/s12603-023-2024-81279-770710.1007/s12603-023-2024-8https://academica-e.unavarra.es/handle/2454/48081Anorexia of aging and biological aging might share physiological underpinnings. The aim of this secondary analysis was to investigate the associations between circulating inflammation-related markers and anorexia of aging in community-dwelling older adults. C-reactive protein (CRP), tumor necrosis factor receptor-1 (TNFR-1), interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1) and growth/differentiation factor-15 (GDF-15) were measured in plasma. Anorexia of aging was defined by the response “severe/moderate decrease in food intake” to the first item of the Mini-Nutritional Assessment. We included 463 subjects (median age=74y, IQR=71–78; 63.1% women). 33 subjects (7.1%) presented with anorexia at baseline, whereas 25 out of 363 (6.9%) developed it along 1-year follow-up. We found that TNFR1 (OR=1.74, 95%CI=1.27–2.39) and GDF-15 (OR=1.38, 95%CI=1.01–1.89) were associated with a significant increase in the odds of presenting with anorexia of aging cross-sectionally. No further significant associations were found. Biological aging mechanisms might be involved in the pathogenesis of anorexia of aging.application/pdfapplication/mswordeng© Serdi and Springer-Verlag International SAS, part of Springer Nature, 2023. CC BY-NC-ND 4.0 Attribution-NonCommercial-NoDerivs 4.0 International.Anorexia of agingBiomarkersInflammationMalnutritioninfo:eu-repo/semantics/article2024-05-08info:eu-repo/semantics/openAccess