Cadenas-Sánchez, CristinaMedrano Echeverría, MaríaVillanueva Larre, ArantxaCabeza Laguna, RafaelIdoate, FernandoOsés Recalde, MaddiRodríguez Vigil, BeatrizÁlvarez de Eulate, NataliaAlberdi Aldasoro, NereaOrtega, Francisco B.Labayen Goñi, Idoia2023-08-212023-08-212023Cadenas-Sanchez, C., Medrano, M., Villanueva, A., Cabeza, R., Idoate, F., Osés, M., Rodríguez-Vigil, B., Álvarez de Eulate, N., Alberdi Aldasoro, N., Ortega, F. B., Labayen, I. (2023) Differences in specific abdominal fat depots between metabolically healthy and unhealthy children with overweight/obesity: the role of cardiorespiratory fitness. Scandinavian Journal of Medicine and Science in Sports, 1-11. https://doi.org/10.1111/sms.14372.0905-718810.1111/sms.14372https://academica-e.unavarra.es/handle/2454/45959Objectives: Fat depots localization has a critical role in the metabolic health status of adults. Nevertheless, whether that is also the case in children remains under- studied. Therefore, the aims of this study were: (i) to examine the differ-ences between metabolically healthy (MHO) and unhealthy (MUO) overweight/obesity phenotypes on specific abdominal fat depots, and (ii) to further explore whether cardiorespiratory fitness plays a major role in the differences between metabolic phenotypes among children with overweight/obesity. Methods: A total of 114 children with overweight/obesity (10.6 ±1.1 years, 62 girls) were included. Children were classified as MHO (n=68) or MUO. visceral (VAT), abdominal subcutaneous (ASAT), intermuscular abdominal (IMAAT), psoas, hepatic, pancreatic, and lumbar bone marrow adipose tissues were measured by magnetic resonance imaging. Cardiorespiratory fitness was assessed using the 20 m shuttle run test. Results: MHO children had lower VAT and ASAT contents and psoas fat fraction compared to MUO children (difference =12.4%– 25.8%, all p<0.035). MUO- unfit had more VAT and ASAT content than those MUO- fit and MHO- fit (difference =34.8%– 45.3%, all p<0.044). MUO- unfit shows also greater IMAAT fat fraction than those MUO- fit and MHO- fit peers (difference =16.4%– 13.9% respectively, all p≤0.001). In addition, MHO- unfit presented higher IMAAT fat fraction than MHO- fit (difference =13.4%, p<0.001). MUO- unfit presented higher psoas fat fraction than MHO- fit (difference =29.1%, p=0.008). Conclusions: VAT together with ASAT and psoas fat fraction, were lower in MHO than in MUO children. Further, we also observed that being fit, regardless of metabolic phenotype, has a protective role over the specific abdominal fat depots among children with overweight/obesity.application/pdfeng© The Author(s) 2023. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.Abdominal subcutaneous fatAerobic capacityHepatic fatLumbar bone marrow fatPancreatic fatPsoas fatVisceral fatYouthArtículo / Artikulua2023-08-21Acceso abierto / Sarbide irekiainfo:eu-repo/semantics/openAccess