Faraji, Ali RezaGil Bravo, AntonioFarahanipour, AlirezaTehrani, ElnazKhoramdareh, Niloufar BakhshiDashtabadi, E.Jafari, Seyede ZeynabShojaei, NajmehHekmatian, ZahraSaeedi, S.2025-07-042025-07-042025-09-01Faraji, A. R., Gil, A., Farahanipour, A., Tehrani, E., Khoramdareh, N. B., Dashtabadi, E., Jafari, S., Shojaei, N., Hekmatian, Z., Saeedi, S. (2025). Synergic removal of Aflatoxin B1 in oily matrices by focusing on the peroxidase-like nanozymes-driven strategies: mechanisms and intermediate toxicity, nutritional impact, advances and challenges. Trends in Food Science & Technology, 163, 1-22. https://doi.org/10.1016/j.tifs.2025.105135.0924-224410.1016/j.tifs.2025.105135https://academica-e.unavarra.es/handle/2454/54394Background: oilseeds and extracted oils, as the supplier of at least 40 % of calories, dietary essential fatty acids, and food flavor, due to insufficient cultivation-harvesting techniques, processing and long-term storage in improper conditions, and lack of adequate food-safety standards and/or official consideration, are prone to contamination by AFB1. Given its irreversible adverse effects on consumer health and food/feed safety due to various factors (e.g., high chemical stability of lipophilic AFB1, transformation to other toxic derivatives, and chemical interaction with oily matrices), developing a decontamination approach from a safety/efficiency perspective is imperative. Scope and approach: this review provides the recent progress on the AFB1 detoxification from oily matrices by focusing on the peroxidase-based nanozymes technologies and enzymatic-like mechanisms of reactive species in detail for the first time. Significantly, the superiority of enzymatic-like activity in capturing/detoxifying AFB1 from oily matrices, change in nutritional quality, organoleptic profiles, and physicochemical properties of oils, and mechanism of action are highlighted by a comparison with various edible oil remediation systems (i.e., physicochemical, physical, chemical, and biological). Key findings and conclusions: The peroxidase nanozyme-based technologies could be of primary importance in the remediation of AFB1 from oily matrices due to the unique merits of nanozymes (e.g., low-cost, size/surface-dependent properties, excellent efficiency and durability/stability, recoverability, biocompatibility, many capabilities to maintain the nutritional quality, and without require to any pre-treatment). Finally, this review aimed to provide several beneficial insights regarding safety, universality, finance, ecology, rapidity, selectivity, detoxification path, and toxicity/biological nature of transformed products in peroxidase-mimicking nanozyme technologies.application/pdfeng© 2025 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license.Aflatoxin B1NanozymePeroxidase-likeEnzyme-mimetic degradationEdible oilDetoxificationinfo:eu-repo/semantics/article2025-07-04info:eu-repo/semantics/openAccess