Zuazo Ibarra, MirenArasanz Esteban, HugoBocanegra Gondán, Ana IsabelChocarro de Erauso, LuisaVera García, Ruth2021-02-042021-02-0420201757-4684 (Electronic)10.15252/emmm.202012706https://academica-e.unavarra.es/handle/2454/39145The search for non-invasive systemic biomarkers of response to PD-L1/PD-1 blockade immunotherapy is currently a priority in oncoimmunology. In contrast to classical tumor biomarkers, the identification of clinically useful immunological biomarkers is certainly a challenge, as anti-cancer immune responses depend on the coordinated action of many cell types. Studies on the dynamics of systemic CD8 T-cell populations have provided indications that such biomarkers may have a place in clinical practice. However, the power of CD8 T-cell subsets to discriminate clinical responses in immunotherapy has so far proven to be limited. The systemic evaluation of CD8 T-cell regulators such as myeloid cells and CD4 T cells may provide the solution. Here we discuss the value of systemic quantification of CD4 T-cell subsets for patient selection in light of the results obtained by Prof. Kagamu′s and our team. Our studies have independently demonstrated that the evaluation of the pre-treatment status of systemic CD4 immunity is a critical factor for the clinical outcome of PD-L1/PD-1 blockade therapy with robust predictive capacities.3 p.application/pdfeng© 2020 The Authors. Published under the terms of the CC BY 4.0 licenseBiomakersImmunityCancerinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccess