Galbete Jiménez, Arkaitz2021-09-242021-09-2420140214-9001https://academica-e.unavarra.es/handle/2454/40570Saiakera klinikoak esperimentu estatistikoen artean kasu bereziak dira bere sekuentzia egiturarengatik eta saiakeraren unitateak gizakiak direlako. Honek erregulazio zorrotza eskatzen du eta datuen biltze eta tratatze prozesuan eragina du, askotan metodologia espezifikoa edo berria erabiliz gainera. Artikulu honetan, saiakera klinikoen diseinuan agertzen diren arazo estatistiko batzuk azaltzen dira, pazienteak tratamenduetan esleitzeko metodo esanguratsu batzuen bilduma bat egiten da eta azken urteotan garrantzia hartzen ari den inferentzia prozesu desberdin bat aurkezten da.Clinical trials are a special case of statistical experiments due to their sequential structure and the fact that the experimental units are patients. This requires a strict regulation with a big effect in the process of data collection and processing, often using specific methodology or a new one. In this article, some statistical issues in the design of clinical trials are explained, a collection of different significant patient randomization rules is made and a randomization based inference process is presented, a topic which is gaining importance in recent years.9 p.application/pdfeusCreative Commons Reconocimiento-NoComercial-CompartirIgual 3.0info:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccess