Lasa Uzcudun, ÍñigoToledo Arana, AlejandroGingeras, Thomas R.2016-11-042016-11-0420121547-6286 (Print)1555-8584 (Electronic)10.4161/rna.21167https://academica-e.unavarra.es/handle/2454/22581This is an accepted manuscript of an article published by Taylor & Francis in RNA Biology on August 1st 2012, available online: http://dx.doi.org/10.4161/rna.21167.Analysis of bacterial transcriptomes have shown the existence of a genome-wide process of overlapping transcription due to the presence of antisense RNAs, as well as mRNAs that overlapped in their entire length or in some portion of the 5′- and 3′-UTR regions. The biological advantages of such overlapping transcription are unclear but may play important regulatory roles at the level of transcription, RNA stability and translation. In a recent report, the human pathogen Staphylococcus aureus is observed to generate genome-wide overlapping transcription in the same bacterial cells leading to a collection of short RNA fragments generated by the endoribonuclease III, RNase III. This processing appears most prominently in Gram-positive bacteria. The implications of both the use of pervasive overlapping transcription and the processing of these double stranded templates into short RNAs are explored and the consequences discussed.application/pdfeng© 2012 Landes BioscienceOverlapping transcriptionRNase IIIRNA processingBacteriaTranscriptomeinfo:eu-repo/semantics/articleAcceso abierto / Sarbide irekiainfo:eu-repo/semantics/openAccess