Cano Montoya, JohnattanRojas-Vargas, MarcelaBáez Vargas, SebastiánNúñez Vergara, CarolinaMartínez-Huenchullán, SergioGallegos, FernandoÁlvarez, CristianIzquierdo Redín, Mikel2025-07-182025-07-182025-04-11Cano-Montoya, J., Rojas Vargas, M., Báez Vargas, S., Núñez Vergara, C., Martínez Huenchullán, S., Gallegos, F., Álvarez, C., Izquierdo, M. (2025) Impact of resistance and high-intensity interval training on body composition, physical function, and temporal dynamics of adaptation in older women with impaired cardiometabolic health: a randomized clinical trial. BMC Sports Science, Medicine and Rehabilitation, 17, 1-17. https://doi.org/10.1186/s13102-025-01119-0.2052-184710.1186/s13102-025-01119-0https://academica-e.unavarra.es/handle/2454/54419Purpose: Physical inactivity is associated with reduced physical fitness (PF) in older women with impaired cardiometabolic health. Although exercise has been shown to improve PF, interindividual variability in response and adaptation changes over time remain unclear. This study evaluated the effects of eight weeks of resistance training (RT) and high-intensity interval training (HIIT) on body composition, isometric strength, and the 6-minute walk test (6MWT) in older women with impaired cardiometabolic health. Additionally, the study explored the reduction of non-responders (NRs) and adaptation changes over time. Methods: This randomized clinical trial involved 36 older women (64 ± 8.4 years; BMI: 31.8 ± 5.5) with impaired cardiometabolic health, divided into RT-G (n = 12; 62 ± 7 years; BMI: 32.2 ± 4.1), HIIT-G (n = 12; 66 ± 10 years; BMI: 31.2 ± 4.1), and CG (n = 12; 64 ± 9 years; BMI: 31.8 ± 6) groups. RT-G performed elastic band exercises, and HIIT-G performed cycle ergometer intervals. BMI, body fat, lean mass, isometric strength, and 6MWT were measured at baseline and at four and eight weeks. The Student’s t-test was applied for normally distributed variables and the Mann–Whitney U test for non-normal variables. Intra- and inter-group differences were analyzed using a two-way repeated measures ANOVA, considering group, time, and their interaction. Post-hoc comparisons were conducted using the Bonferroni test. Individual responses (IR) were calculated using the equation proposed by Hopkins: SDIR = √(SDExp2 − SDCon2). The prevalence of responders (Rs) and non-responders (NRs) was expressed as a percentage, and percentage changes from baseline to weeks four and eight were used to evaluate adaptations dynamics. Results: By week eight, isometric strength in RT-G significantly improved from 21.3 ± 4.4 to 24.37 ± 3.99 kg (p = 0.027; 95% CI: 1.8, 4.3 kg; Cohen’s d = 0.731) and 6MWT distance in HIIT-G increased from 441.0 ± 48.9 to 480.0 ± 53.0 m. (p = 0.002; 95% CI: 22, 55 m; Cohen’s d = 0.757). Both protocols reduced NRs for body fat, lean mass, and 6MWT. Responders showed greater adaptations in the first four weeks, stabilizing by week eight. Conclusion: RT and HIIT improved PF in older women with impaired cardiometabolic health, reducing NRs in terms of body composition and 6MWT over eight weeks, with similar adaptation changes over time among the responders. These findings highlight the importance of individualized exercise interventions to maximize health benefits. Trial registration: This study was part of a trial registered at ClinicalTrials.gov (ID: NCT06201273). Date: 22/12/2023.application/pdfeng© The Author(s) 2025. This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material.Resistance training (RT)High-intensity interval training (HIIT)Interindividual responseTemporal dynamics of adaptationCardiometabolic risk factorsPhysical fitnessinfo:eu-repo/semantics/article2025-07-18info:eu-repo/semantics/openAccess