Anti-inflammatory and antioxidant capacity of a fruit and vegetable-based nutraceutical measured by urinary oxylipin concentration in a healthy population: a randomized, double-blind, placebo-controlled clinical trial

Arcusa, RaúlCarrillo, Juan ÁngelCerdá, BegoñaDurand, ThierryGil-Izquierdo, ÁngelMedina, SoniaGalano, Jean-MarieVillaño Valencia, DéboraMarhuenda, JavierZafrilla, Pilar2023-09-052023-09-052022Arcusa, R., Carrillo, J. Á., Cerdá, B., Durand, T., Gil-Izquierdo, Á., Medina, S., Galano, J.-M., Villaño Valencia, D., Marhuenda, J., & Zafrilla, P. (2022). Anti-inflammatory and antioxidant capacity of a fruit and vegetable-based nutraceutical measured by urinary oxylipin concentration in a healthy population: A randomized, double-blind, placebo-controlled clinical trial. Antioxidants, 11(7), 1342. https://doi.org/10.3390/antiox110713422076-392110.3390/antiox11071342https://academica-e.unavarra.es/handle/2454/46218Oxylipins, lipid biomarkers of inflammation are considered the gold standard method to evaluate the inflammatory and antioxidant status. The aim of the present study was to investigate whether the administration of a polyphenolic extract shot in the form of a nutraceutical was able to reduce inflammation, measured in urine markers. Ninety-two participants (45 males, 47 females, age 34 ± 11 years, weight 73.10 ± 14.29 kg, height 1.72 ± 9 cm, BMI 24.40 ± 3.43 kg/m2 ) completed the study after an intervention of two 16-week periods consuming extract or placebo separated by a 4-week washout period. The results showed significant differences in terms of reduction of different pro-inflammatory oxylipins (15-keto-PGF2α (from 0.90 ± 0.25 ng/mL to 0.74 ± 0.19 ng/mL p < 0.05), ent-PGF2α (from 1.59 ± 0.37 ng/mL to 1.44 ± 0.32 ng/mL p < 0.05), 2,3-dinor-15-F2t-Isop) (from 1.17 ± 0.35 ng/mL to 1.02 ± 0.27 ng/mL p < 0.05), in total oxylipins count (from 8.03 ± 1.86 ng/mL to 7.25 ± 1.23 ng/mL p < 0.05), and increase in PGE2 (from 1.02 ± 0.38 ng/mL to 1.26 ± 0.38 ng/mL p < 0.05) which has an anti-inflammatory character, after extract consumption compared to placebo. The available data seem to indicate that long-term consumption of a nutraceutical with high polyphenol content improves inflammation and oxidation parameters measured in urine, through UHPLCQqQ-ESI-MS/MS.application/pdfeng© 2022 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.Oxidative stressMetabolic syndromeInflammationMetabolic diseasesIsoprostanesOxylipinsAnti-inflammatory and antioxidant capacity of a fruit and vegetable-based nutraceutical measured by urinary oxylipin concentration in a healthy population: a randomized, double-blind, placebo-controlled clinical trialinfo:eu-repo/semantics/article2023-09-05info:eu-repo/semantics/openAccess