Asymmetric assembly of all‐carbon tertiary/quaternary nonadjacent stereocenters through organocatalytic conjugate addition of α‐cyanoacetates to a methacrylate equivalent

Iriarte, IgorVera, SilviaBadiola, EiderMielgo, AntoniaOiarbide, MikelGarcía Castillo, Jesús MaríaOdriozola Ibarguren, José ManuelPalomo, Claudio2024-01-302024-01-302016Iriarte, I., Vera, S., Badiola, E., Mielgo, A., Oiarbide, M., García, J. M., Odriozola, J. M., & Palomo, C. (2016). Asymmetric assembly of all‐carbon tertiary/quaternary nonadjacent stereocenters through organocatalytic conjugate addition of α‐cyanoacetates to a methacrylate equivalent. Chemistry – A European Journal, 22(38), 13690-13696. https://doi.org/10.1002/chem.2016030820947-653910.1002/chem.201603082https://academica-e.unavarra.es/handle/2454/47251An efficient, highly diastereo- and enantioselective assembly of acyclic carbonyl fragments possessing nonadjacent all-carbon tertiary/quaternary stereoarrays is reported based on a Brønsted base catalyzed Michael addition/a-protonation sequence involving a-cyanoacetates and 2,4-dimethyl-4-hydroxypenten-3-one as novel methacrylate equivalent.application/pdfeng© 2016 Wiley-VCH Verlag GmbH & Co.Asymmetric organocatalysisMichael reactionsStereoselective protonationQuaternary stereocentersBrønsted basesAsymmetric assembly of all‐carbon tertiary/quaternary nonadjacent stereocenters through organocatalytic conjugate addition of α‐cyanoacetates to a methacrylate equivalentArtículo / Artikulua2024-01-30Acceso abierto / Sarbide irekiainfo:eu-repo/semantics/openAccess