Vázquez Urio, IriaMaicas, MirenMarcotegui, NereaConchillo, AnaGuruceaga, ElizabethRomán-Gómez, JoséCalasanz, María JoséAgirre, XabierPrósper, FelipeOdero, María D.2025-01-142025-01-142010-01-07Vázquez, I., Maicas, M., Marcotegui, N., Conchillo, A., Guruceaga, E., Roman-Gomez, J., Calasanz, M. J., Agirre, X., Prosper, F., Odero, M. D. (2010). Silencing of hsa-miR-124 by EVI1 in cell lines and patients with acute myeloid leukemia. Proceedings of the National Academy of Sciences of the United States of America, 107(44), 167-168. https://doi.org/10.1073/pnas.1011540107.0027-842410.1073/pnas.1011540107https://academica-e.unavarra.es/handle/2454/52918Acceso cerrado a este documento. No se encuentra disponible para la consulta pública. Depositado en Academica-e para cumplir con los requisitos de evaluación y acreditación académica del autor/a (sexenios, acreditaciones, etc.).We read with great interest the work published by Dickstein et al. (1) showing that induced EVI1 expression in a murine model silences miR-124 expression by DNA methylation. The EVI1 gene codes for a transcription factor implicated in the development and progression of high-risk acute myeloid leukemia (AML) (2, 3). We quantify the expression of 250 microRNAs (miRNAs; TaqManHuman miRNA assay set) in 15 myeloid cell lines. Statistical analysis comparing cell lines with and without EVI1 protein identified miRNAs differentially expressed (B > 0)application/pdfeng© 2010 PNASEVI1 Overexpressionhsa-miR-124 SilencingDNA Methylationinfo:eu-repo/semantics/article2025-01-14info:eu-repo/semantics/closedAccess