Cuesta, Manuel J.Campos, María S.García de Jalón, ElenaSánchez Torres, Ana MaríaPeralta Martín, Víctor2024-01-302024-01-302012Cuesta, M. J., Campos, M. S., García-Jalón, E., Sánchez-Torres, A. M., & Peralta, V. (2012). Treatment response of neurological soft signs in drug-naïve patients with a first psychotic episode. Schizophrenia Research, 139(1-3), 144-150. https://doi.org/10.1016/j.schres.2012.05.0190920-996410.1016/j.schres.2012.05.019https://academica-e.unavarra.es/handle/2454/47244Background: Neurological soft signs (NSS) are intrinsic features of psychosis that appear years before beginning a drug treatment. However, whether NSS respond to antipsychotics and whether these changes are clinically reliable and significant remains to be seen. Objective: We sought to determine the effect of antipsychotics on NSS in a first-episode psychosis (FEP) sample who had never exposed to antipsychotics. Methods: We included 100 antipsychotic-naïve patients with FEP in this study. 77 patients completed the study assessments at baseline, 1 month and 6 months. The Neurological Evaluation Scale (NES) evaluated NSS. Patients were alternatively selected to receive risperidone or olanzapine treatments and continued participation in their mental health setting during follow-up with one of four treatment groups: risperidone, olanzapine, mixed antipsychotics or no medication. We also included a control group of 28 healthy volunteers. Results: Treatment groups showed a statistically significant improvement on total NES scores and most NES subscales except for ‘frontal signs’, regardless of antipsychotic allocation. NSS changes were reliable; however, there was great variation in the total NES scores between treatment groups, ranging from 4% to 24%. Clinically meaningful changes (CMCs) on total NES scores ranged from 25% to 50%. Six patients (7.8%) demonstrated a reliable change (RC) and CMC on total NES scores. Conclusions: NSS improved significantly over follow up regardless of the treatment regimen assigned to antipsychotic-naïve patients with a FEP. However, only 6 (7.8%) achieved a reliable and clinically meaningful improvement. The pattern of response of NSS to antipsychotic drugs evidenced both state and trait characteristics.application/pdfeng© 2012 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0.Neurological soft signsPsychosisSchizophreniaFirst-episode psychosisDrug-naïve patientsNever-treated patientsArtículo / Artikulua2024-01-30Acceso abierto / Sarbide irekiainfo:eu-repo/semantics/openAccess