Cuesta, Manuel J.García de Jalón, ElenaSánchez Torres, Ana MaríaGil Berrozpe, Gustavo JoséAranguren Conde, LidiaGutiérrez, GerardoCorrales, AsierZarzuela, AmaliaIbáñez Beroiz, BertaPeralta Martín, VíctorPEPsNa Group2024-09-092024-09-092024Cuesta, M. J., De Jalón, E. G., Sánchez-Torres, A. M., Gil-Berrozpe, G. J., Aranguren, L., Gutierrez, G., Corrales, A., Zarzuela, A., Ibañez, B., Peralta, V., Group, Pep (2024) Additive effects of a family history of schizophrenia spectrum disorders and an environmental risk score for the outcome of patients with non-affective first-episode psychosis. Psychological Medicine, 1-9. https://doi.org/10.1017/S0033291724000576.0033-291710.1017/S0033291724000576https://academica-e.unavarra.es/handle/2454/51557Background: First-episode psychotic disorders comprise a heterogeneous phenotype with a complex etiology involving numerous common small-effect genetic variations and a wide range of environmental exposures. We examined whether a family of schizophrenia spectrum disorder (FH-Sz) interacts with an environmental risk score (ERS-Sz) regarding the outcome of patients with non-affective first episode psychosis (NAFEP). Methods: We included 288 patients with NAFEP who were evaluated after discharge from an intensive 2-year program. We evaluated three outcome measures: symptomatic remission, psychosocial functioning, and personal recovery. We analyzed the main and joint associations of a FH-Sz and the ERS-Sz on the outcomes by using the relative excess risk due to interaction (RERI) approach. Results: A FH-Sz showed a significant association with poor symptomatic remission and psychosocial functioning outcomes, although there was no significant interaction between a FH-Sz and the ERS-Sz on these outcomes. The ERS-Sz did not show a significant association with poor symptomatic remission and psychosocial functioning outcomes, even though the magnitude of the interaction between ERS-Sz and FH-Sz with the later outcome was moderate (RERI = 6.89, 95% confidence interval -16.03 to 29.81). There was no association between a FH-Sz and the ERS-Sz and personal recovery. Conclusions: Our results provide further empirical support regarding the contribution of FH-Sz to poor symptomatic remission and poor psychosocial functioning outcomes in patients with NAFEP.application/pdfapplication/zipeng© The Author(s), 2024.Environmental risk scoreFamily of schizophrenia spectrum disorderFirst-episode psychosisNon-affective psychosisRERIinfo:eu-repo/semantics/article2024-09-09info:eu-repo/semantics/openAccess