Crespo Otano, HelenaJauregui, PaulaGlaría Ezquer, IdoiaSanjosé, LeticiaPolledo, LauraGarcía Marín, Juan F.Luján, LluísAndrés Cara, Damián deAmorena Zabalza, BeatrizReina Arias, Ramsés2015-09-302015-09-3020120928-4249 (print)1297-9716 (electronic)10.1186/1297-9716-43-43https://academica-e.unavarra.es/handle/2454/18320Thirty-one sheep naturally infected with small ruminant lentiviruses (SRLV) of known genotype (A or B), and clinically affected with neurological disease, pneumonia or arthritis were used to analyse mannose receptor (MR) expression (transcript levels) and proviral load in virus target tissues (lung, mammary gland, CNS and carpal joints). Control sheep were SRLV-seropositive asymptomatic (n = 3), seronegative (n = 3) or with chronic listeriosis, pseudotuberculosis or parasitic cysts (n = 1 in each case). MR expression and proviral load increased with the severity of lesions in most analyzed organs of the SRLV infected sheep and was detected in the affected tissue involved in the corresponding clinical disease (CNS, lung and carpal joint in neurological disease, pneumonia and arthritis animal groups, respectively). The increased MR expression appeared to be SRLV specific and may have a role in lentiviral pathogenesis.application/pdfeng© 2012 Crespo et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Maedi VisnaAlveolar macrophagesVirus-infectionSheepExpressionDiagnosisCorrelateLesionSystemLoadinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessAcceso abierto / Sarbide irekia