Martín Peláez, SandraSerra-Majem, LluisCano Ibáñez, NoemíMartínez González, Miguel ÁngelSalas-Salvadó, JordiCorella, DoloresLassale, CamilleMartínez, Jose AlfredoAlonso Gómez, Ángel M.Wärnberg, JuliaVioque, JesúsRomaguera, DoraLópez Miranda, JoséEstruch, RamónTinahones, Francisco J.Lapetra, JoséFernández-Aranda, FernandoBueno Cavanillas, AuroraTur, Josep A.Martín, VicentePintó, XavierDelgado Rodríguez, MiguelMatía, PilarVidal, JosepVázquez, ClotildeDaimiel, LidiaRos, EmilioToledo, EstefaníaNishi, Stephanie K.Sorli, Jose V.Malcampo, MireiaZulet, María ÁngelesMoreno Rodríguez, AnaíCueto Galán, RaquelVivancos Aparicio, DiegoColom, AntoniGarcía-Rios, AntonioCasas, RosaBernal López, M. RosaSantos Lozano, José ManuelVázquez, ZenaidaGómez-Martínez, CarlosOrtega Azorín, CarolinaVal, José Luis delAbete, ItziarGoikoetxea Bahon, AmaiaPascual, ElenaBecerra-Tomás, NereaChillarón, Juan J.Sánchez Villegas, María Almudena2022-09-052022-09-052022Martín-Peláez, S.; Serra-Majem, L.; Cano-Ibáñez, N.; Martínez-González, M. Á.; Salas-Salvadó, J.; Corella, D.; Lassale, C.; Martínez, J. A.; Alonso-Gómez, Á. M.; Wärnberg, J.; Vioque, J.; Romaguera, D.; López-Miranda, J.; Estruch, R.; Tinahones, F. J.; Lapetra, J.; Fernández-Aranda, F.; Bueno-Cavanillas, A.; Tur, J. A.; Martín, V.; Pintó, X.; Delgado-Rodríguez, M.; Matía, P.; Vidal, J.; Vázquez, C.; Daimiel, L.; Ros, E.; Toledo, E.; Nishi, S. K.; Sorli, J. V.; Malcampo, M.; Zulet, M. Á.; Moreno-Rodríguez, A.; Cueto-Galán, R.; Vivancos-Aparicio, D.; Colom. A.; García-Ríos, A.; Casas, R.; Bernal-López, M. R.; Santos-Lozano, J. M.; Vázquez, Z.; Gómez-Martínez, C.; Ortega-Azorín, C.; del Val, J. L.; Abete, I.; Goikoetxea-Bahon, A.; Pascual, E.; Becerra-Tomás, N.; Chillarón, J. J.; Sánchez-Villegas, A.. (2022). Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study. PloS one. 17,4 1-18 .1932-620310.1371/journal.pone.0265079https://academica-e.unavarra.es/handle/2454/43953Background Cardio-vascular disease and depression are thought to be closely related, due to shared risk factors. The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and depressive status in a population (55-75 years) with metabolic syndrome (MetS) from the PREDIMED-Plus trial. Methods and findings Participants were classified into three groups of CVR according to the Framingham-based REGICOR function: (1) low (LR), (2) medium (MR) or (3) high/very high (HR). The Beck Depression Inventory-II (BDI-II) was used to assess depressive symptoms at baseline and after 2 years. The association between CVR and depressive status at baseline (n = 6545), and their changes after 2 years (n = 4566) were evaluated through multivariable regression models (logistic and linear models). HR women showed higher odds of depressive status than LR [OR (95% CI) = 1.78 (1.26, 2.50)]. MR and HR participants with total cholesterol <160 mg/mL showed higher odds of depression than LR [OR (95% CI) = 1.77 (1.13, 2.77) and 2.83 (1.25, 6.42) respectively)] but those with total cholesterol ¿280 mg/mL showed lower odds of depression than LR [OR (95% CI) = 0.26 (0.07, 0.98) and 0.23 (0.05, 0.95), respectively]. All participants decreased their BDI-II score after 2 years, being the decrease smaller in MR and HR diabetic compared to LR [adjusted mean±SE = -0.52±0.20, -0.41 ±0.27 and -1.25±0.31 respectively). MR and HR participants with total cholesterol between 240-279 mg/mL showed greater decreases in the BDI-II score compared to LR (adjusted mean±SE = -0.83±0.37, -0.77±0.64 and 0.97±0.52 respectively). Conclusions Improving cardiovascular health could prevent the onset of depression in the elderly. Diabetes and total cholesterol in individuals at high CVR, may play a specific role in the precise response.application/pdfeng© 2022 Martín-Peláez et al. This is an open access article distributed under the terms of the Creative Commons Attribution LicenseCardio-vascular risk factorsPredimed-plusCardio-vascular diseaseDepressioninfo:eu-repo/semantics/article2022-09-05info:eu-repo/semantics/openAccess