Martínez Téllez, BorjaSánchez Delgado, GuillermoAcosta, Francisco M.Alcántara Alcántara, Juan ManuelAmaro Gahete, Francisco J.Martínez Ávila, Wendy D.Merchán Ramírez, ElisaMuñoz-Hernández, VictoriaOsuna Prieto, Francisco J.Jurado Fasoli, LucasXu, HuiwenOrtiz Álvarez, LourdesArias Téllez, María J.Méndez Gutiérrez, AndreaLabayen Goñi, IdoiaOrtega, Francisco B.Schönke, MilenaRensen, Patrick C. NAguilera, Concepción MaríaLlamas Elvira, José M.Gil, ÁngelRuiz, Jonatan R.2023-03-242023-03-242022Martinez-Tellez, B., Sanchez-Delgado, G., Acosta, F. M., Alcantara, J. M. A., Amaro-Gahete, F. J., Martinez-Avila, W. D., Merchan-Ramirez, E., Muñoz-Hernandez, V., Osuna-Prieto, F. J., Jurado-Fasoli, L., Xu, H., Ortiz-Alvarez, L., Arias-Tellez, M. J., Mendez-Gutierrez, A., Labayen, I., Ortega, F. B., Schönke, M., Rensen, P. C. N., Aguilera, C. M., … Ruiz, J. R. (2022). No evidence of brown adipose tissue activation after 24 weeks of supervised exercise training in young sedentary adults in the ACTIBATE randomized controlled trial. Nature Communications, 13(1), 5259. https://doi.org/10.1038/s41467-022-32502-x2041-172310.1038/s41467-022-32502-xhttps://academica-e.unavarra.es/handle/2454/44936Exercise modulates both brown adipose tissue (BAT) metabolism and white adipose tissue (WAT) browning in murine models. Whether this is true in humans, however, has remained unknown. An unblinded randomized controlled trial (ClinicalTrials.gov ID: NCT02365129) was therefore conducted to study the effects of a 24-week supervised exercise intervention, combining endurance and resistance training, on BAT volume and activity (primary outcome). The study was carried out in the Sport and Health University Research Institute and the Virgen de las Nieves University Hospital of the University of Granada (Spain). One hundred and forty-five young sedentary adults were assigned to either (i) a control group (no exercise, n = 54), (ii) a moderate intensity exercise group (MOD-EX, n = 48), or (iii) a vigorous intensity exercise group (VIG-EX n = 43) by unrestricted randomization. No relevant adverse events were recorded. 97 participants (34 men, 63 women) were included in the final analysis (Control; n = 35, MOD-EX; n = 31, and VIG-EX; n = 31). We observed no changes in BAT volume (Δ Control: −22.2 ± 52.6 ml; Δ MOD-EX: −15.5 ± 62.1 ml, Δ VIG-EX: −6.8 ± 66.4 ml; P = 0.771) or 18F-fluorodeoxyglucose uptake (SUVpeak Δ Control: −2.6 ± 3.1 ml; Δ MOD-EX: −1.2 ± 4.8, Δ VIG-EX: −2.2 ± 5.1; p = 0.476) in either the control or the exercise groups. Thus, we did not find any evidence of an exercise-induced change on BAT volume or activity in young sedentary adults.application/pdfeng© The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.Brown adipose tissueExerciseYoung sedentary adultsinfo:eu-repo/semantics/article2023-03-23info:eu-repo/semantics/openAccess