Lasa Uzcudun, ÍñigoSolano Goñi, CristinaDorado Morales, Pedro2021-11-262023-01-0820212021-01-0810.48035/Tesis/2454/41085https://academica-e.unavarra.es/handle/2454/41085Staphylococcus aureus is a versatile human pathogen that has emerged as one of the most successful infectious agents of recent times, able to cause a range of diseases including skin and soft tissue infections, endocarditis, sepsis, pneumonia, osteomyelitis, bacteremia, and abscesses in organ tissues. Besides its clinical relevance, S. aureus has served as a model to study fundamental cellular processes, such as biofilm formation, the regulatory functions of small RNAs or growth and division of spherical cocci. Based on the accumulated knowledge of S. aureus biology, the availability of database resources and the advances in high-throughput genome sequencing, in this work we have aimed at developing new genetic tools derived from S. aureus for biotechnological applications in Gram-positive bacteria.235 p.application/pdfengStaphylococcus aureusBiofilmsCRISPR/Cas9Rhodococcus erythropolisinfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/openAccessAcceso abierto / Sarbide irekia