Now showing items 1-20 of 32

    • Bap, a biofilm matrix protein of Staphylococcus aureus prevents cellular internalization through binding to GP96 host receptor 

      Valle Turrillas, Jaione Upna Orcid; Latasa Osta, Cristina Upna; Gil Puig, Carmen Upna Orcid; Toledo Arana, Alejandro Upna Orcid; Solano Goñi, Cristina Upna Orcid; Penadés, José R.; Lasa Uzcudun, Íñigo Upna Orcid (Public Library of Science, 2012)   Artículo / Artikulua  OpenAccess
      The biofilm matrix, composed of exopolysaccharides, proteins, nucleic acids and lipids, plays a well-known role as a defence structure, protecting bacteria from the host immune system and antimicrobial therapy. However, ...
    • Bap, a Staphylococcus aureus surface protein involved in biofilm formation 

      Cucarella, Carme; Solano Goñi, Cristina Upna Orcid; Valle Turrillas, Jaione Upna Orcid; Amorena Zabalza, Beatriz Upna; Lasa Uzcudun, Íñigo Upna Orcid; Penadés, José R. (American Society for Microbiology, 2001)   Artículo / Artikulua  OpenAccess
      Identification of new genes involved in biofilm formation is needed to understand the molecular basis of strain variation and the pathogenic mechanisms implicated in chronic staphylococcal infections. A biofilm-producing ...
    • Base pairing interaction between 5′- and 3′-UTRs controls icaR mRNA translation in Staphylococcus aureus 

      Ruiz de los Mozos Aliaga, Igor Upna; Vergara Irigaray, Marta Upna; Segura, Víctor; Villanueva San Martín, Maite Upna Orcid; Bitarte, Nerea Upna; Saramago, Margarida; Domingues, Susana; Arraiano, Cecilia M.; Fechter, Pierre; Romby, Pascale; Valle Turrillas, Jaione Upna Orcid; Solano Goñi, Cristina Upna Orcid; Lasa Uzcudun, Íñigo Upna Orcid; Toledo Arana, Alejandro Upna Orcid (Public Library of Science, 2013)   Artículo / Artikulua  OpenAccess
      The presence of regulatory sequences in the 39 untranslated region (39-UTR) of eukaryotic mRNAs controlling RNA stability and translation efficiency is widely recognized. In contrast, the relevance of 39-UTRs in bacterial ...
    • Biofilm dispersion and quorum sensing 

      Solano Goñi, Cristina Upna Orcid; Echeverz Sarasúa, Maite Upna Orcid; Lasa Uzcudun, Íñigo Upna Orcid (Elsevier, 2014)   Artículo / Artikulua  OpenAccess
      Biofilm development and quorum sensing are closely interconnected processes. Biofilm formation is a cooperative group behaviour that involves bacterial populations living embedded in a self produced extracellular matrix. ...
    • Biofilm matrix exoproteins induce a protective immune response against Staphylococcus aureus biofilm infection 

      Gil Puig, Carmen Upna Orcid; Solano Goñi, Cristina Upna Orcid; Burgui Erice, Saioa Upna Orcid; Latasa Osta, Cristina Upna; García Martínez, Begoña Upna Orcid; Toledo Arana, Alejandro Upna Orcid; Lasa Uzcudun, Íñigo Upna Orcid; Valle Turrillas, Jaione Upna Orcid (American Society for Microbiology, 2014)   Artículo / Artikulua  OpenAccess
      The Staphylococcus aureus biofilm mode of growth is associated with several chronic infections that are very difficult to treat due to the recalcitrant nature of biofilms to clearance by antimicrobials. Accordingly, there ...
    • Biofilm switch and immune response determinants at early stages of infection 

      Valle Turrillas, Jaione Upna Orcid; Solano Goñi, Cristina Upna Orcid; García Martínez, Begoña Upna Orcid; Toledo Arana, Alejandro Upna Orcid; Lasa Uzcudun, Íñigo Upna Orcid (Elsevier (Cell Press), 2013)   Artículo / Artikulua  OpenAccess
      Biofilm development is recognized as a major virulence factor underlying most chronic bacterial infections. When a biofilm community is established, planktonic cells growing in the surroundings of a tissue switch to a ...
    • Biofuncionalización de nanoestructuras para aplicación en sistemas de detección 

      Ciáurriz Gortari, Paula (2017)   Tesis doctoral / Doktoretza tesia  OpenAccess
      La presente tesis doctoral, enmarcada en el campo de nanobiotecnología, presenta el desarrollo de diversas estrategias de biofuncionalización de nanoestructuras con diferentes propiedades con el fin de ser aplicadas en ...
    • Coordinated cyclic-di-GMP repression of salmonella motility through YcgR and cellulose 

      Zorraquino Salvo, Violeta; García Martínez, Begoña Upna Orcid; Latasa Osta, Cristina Upna; Echeverz Sarasúa, Maite Upna Orcid; Toledo Arana, Alejandro Upna Orcid; Valle Turrillas, Jaione Upna Orcid; Lasa Uzcudun, Íñigo Upna Orcid; Solano Goñi, Cristina Upna Orcid (American Society for Microbiology, 2013)   Artículo / Artikulua  OpenAccess
      Cyclic di-GMP (c-di-GMP) is a secondary messenger that controls a variety of cellular processes, including the switch between a biofilm and a planktonic bacterial lifestyle. This nucleotide binds to cellular effectors in ...
    • A DIVA vaccine strain lacking RpoS and the secondary messenger c-di-GMP for protection against salmonellosis in pigs 

      Gil Puig, Carmen Upna Orcid; Latasa Osta, Cristina Upna; García Ona, Enrique Upna; Lázaro, Isidro; Labairu, Javier; Echeverz Sarasúa, Maite Upna Orcid; Burgui Erice, Saioa Upna Orcid; García Martínez, Begoña Upna Orcid; Lasa Uzcudun, Íñigo Upna Orcid; Solano Goñi, Cristina Upna Orcid (BioMed Central, 2020)   Artículo / Artikulua  OpenAccess
      Salmonellosis is the second most common food-borne zoonosis in the European Union, with pigs being a major reservoir of this pathogen. Salmonella control in pig production requires multiple measures amongst which vaccination ...
    • Elevated c-di-GMP levels promote biofilm formation and biodesulfurization capacity of Rhodococcus erythropolis 

      Dorado Morales, Pedro Upna Orcid; Martínez, Igor; Rivero Buceta, Virginia; Díaz, Eduardo; Bähre, Heike; Lasa Uzcudun, Íñigo Upna Orcid; Solano Goñi, Cristina Upna Orcid (Society for Applied MicrobiologyJohn Wiley & Sons, 2020)   Artículo / Artikulua  OpenAccess
      Bacterial biofilms provide high cell density and a superior adaptation and protection from stress conditions compared to planktonic cultures, making them a very promising approach for bioremediation. Several Rhodococcus ...
    • The enterococcal surface protein, Esp, is involved in Enterococcus faecalis biofilm formation 

      Toledo Arana, Alejandro Upna Orcid; Valle Turrillas, Jaione Upna Orcid; Solano Goñi, Cristina Upna Orcid; Arrizubieta Balerdi, María Jesús Upna; Cucarella, Carme; Lamata, Marta; Amorena Zabalza, Beatriz Upna; Leiva, José; Penadés, José R.; Lasa Uzcudun, Íñigo Upna Orcid (American Society for Microbiology, 2001)   Artículo / Artikulua  OpenAccess
      The enterococcal surface protein, Esp, is a high-molecular-weight surface protein of unknown function whose frequency is significantly increased among infection-derived Enterococcus faecalis isolates. In this work, a ...
    • Etnobotánica de wirikuta: uso de recursos vegetales silvestres en el desierto de San Luis Potosí, México 

      Solano Goñi, Cristina Upna Orcid; Blancas, José (Asociación Etnobiológica Mexicana A.C., 2018)   Artículo / Artikulua  OpenAccess
      La presente investigación se llevó a cabo en el ejido Las Margaritas ubicado en el municipio de Catorce, dentro de la Reserva Ecológica Natural y Cultural de Wirikuta (RW), San Luis Potosí, México. Esta se localiza en la ...
    • Evaluation of a Salmonella strain lacking the secondary messenger c-di-GMP and RpoS as a live oral vaccine 

      Latasa Osta, Cristina Upna; Echeverz Sarasúa, Maite Upna Orcid; García Ona, Enrique Upna; Burgui Erice, Saioa Upna Orcid; Casares, Noelia; Hervás Stubbs, Sandra Upna; Lasarte, Juan José; Lasa Uzcudun, Íñigo Upna Orcid; Solano Goñi, Cristina Upna Orcid; García Martínez, Begoña Upna Orcid; Gil Puig, Carmen Upna Orcid (Public Library of Science, 2016)   Artículo / Artikulua  OpenAccess
      Salmonellosis is one of the most important bacterial zoonotic diseases transmitted through the consumption of contaminated food, with chicken and pig related products being key reservoirs of infection. Although numerous ...
    • Evaluation of surface microtopography engineered by direct laser interference for bacterial anti-biofouling 

      Valle Turrillas, Jaione Upna Orcid; Burgui Erice, Saioa Upna Orcid; Langheinrich, Denise; Gil Puig, Carmen Upna Orcid; Solano Goñi, Cristina Upna Orcid; Toledo Arana, Alejandro Upna Orcid; Helbig, Ralf; Lasagni, Andrés; Lasa Uzcudun, Íñigo Upna Orcid (2015)   Artículo / Artikulua  OpenAccess
      Biofilm formation by bacterial pathogens on the surface of medical and industrial settings is a 25 serious health problem. Modification of the biomaterial surface topography is a promising 26 strategy to prevent bacterial ...
    • Experimental polymorphism survey in intergenic regions of the icaADBCR locus in Staphylococcus aureus isolates from periprosthetic joint infections 

      Morales Laverde, Liliana Andrea; Echeverz Sarasúa, Maite Upna Orcid; Trobos, Margarita; Solano Goñi, Cristina Upna Orcid; Lasa Uzcudun, Íñigo (MDPI, 2022)   Artículo / Artikulua  OpenAccess
      Staphylococcus aureus is a leading cause of prosthetic joint infections (PJI) characterized by bacterial biofilm formation and recalcitrance to immune-mediated clearance and antibiotics. The molecular events behind PJI ...
    • Fitness cost evolution of natural plasmids of staphylococcus aureus 

      Dorado Morales, Pedro Upna Orcid; Garcillán-Barcia, María Pilar; Lasa Uzcudun, Íñigo Upna Orcid; Solano Goñi, Cristina Upna Orcid (American Society for Microbiology, 2021)   Artículo / Artikulua  OpenAccess
      Plasmids have largely contributed to the spread of antimicrobial resistance genes among Staphylococcus strains. Knowledge about the fitness cost that plasmids confer on clinical staphylococcal isolates and the coevolutionary ...
    • Fluorescent molecular beacons mimicking RNA secondary structures to study RNA chaperone activity 

      Menéndez Gil, Pilar; Caballero Sánchez, Carlos Upna; Solano Goñi, Cristina Upna Orcid; Toledo Arana, Alejandro Upna Orcid (Humana Press, 2020)   Capítulo de libro / Liburuen kapitulua  OpenAccess
      Molecular beacons (MBs) are oligonucleotide probes with a hairpin-like structure that are typically labelled at the 5′ and 3′ ends with a fluorophore and a quencher dye, respectively. The conformation of the MB acts as a ...
    • Genetic reductionist approach for dissecting individual roles of GGDEF proteins within the c-di-GMP signaling network in Salmonella 

      Solano Goñi, Cristina Upna Orcid; García Martínez, Begoña Upna Orcid; Latasa Osta, Cristina Upna; Toledo Arana, Alejandro Upna Orcid; Zorraquino Salvo, Violeta; Valle Turrillas, Jaione Upna Orcid; Casals, Joan; Pedroso, Enrique; Lasa Uzcudun, Íñigo Upna Orcid (National Academy of Sciences, 2009)   Artículo / Artikulua  OpenAccess
      Bacteria have developed an exclusive signal transduction system involving multiple diguanylate cyclase and phosphodiesterase domain-containing proteins (GGDEF and EAL/HD-GYP, respectively) that modulate the levels of the ...
    • Genetic tools derived from Staphylococcus aureus for biotechnological applications in Gram-positive bacteria 

      Dorado Morales, Pedro Upna Orcid (2021)   Tesis doctoral / Doktoretza tesia  OpenAccess
      Staphylococcus aureus is a versatile human pathogen that has emerged as one of the most successful infectious agents of recent times, able to cause a range of diseases including skin and soft tissue infections, endocarditis, ...
    • Genome-wide antisense transcription drives mRNA processing in bacteria 

      Lasa Uzcudun, Íñigo Upna Orcid; Toledo Arana, Alejandro Upna Orcid; Dobin, Alexander; Villanueva San Martín, Maite Upna Orcid; Ruiz de los Mozos Aliaga, Igor Upna; Vergara Irigaray, Marta Upna; Segura, Víctor; Fagegaltier, Delphine; Penadés, José R.; Valle Turrillas, Jaione Upna Orcid; Solano Goñi, Cristina Upna Orcid; Gingeras, Thomas R. (National Academy of Sciences, 2011)   Artículo / Artikulua  OpenAccess
      RNA deep sequencing technologies are revealing unexpected levels of complexity in bacterial transcriptomes with the discovery of abundant noncoding RNAs, antisense RNAs, long 5′ and 3′ untranslated regions, and alternative ...