Now showing items 1-20 of 23

    • Antidiabetic effects of Pediococcus acidilactici pA1c on HFD-induced mice 

      Cabello Olmo, Miriam; Oneca, María Upna; Pajares Villandiego, María Josefa Upna; Jiménez, Maddalen; Ayo, Josune; Encío Martínez, Ignacio Upna Orcid; Barajas Vélez, Miguel Ángel Upna Orcid; Araña Ciordia, Miriam Upna Orcid (MDPI, 2022)   Artículo / Artikulua  OpenAccess
      Prediabetes (PreD), which is associated with impaired glucose tolerance and fasting blood glucose, is a potential risk factor for type 2 diabetes mellitus (T2D). Growing evidence suggests the role of the gastrointestinal ...
    • Changes in gene expression profiling of apoptotic genes in neuroblastoma cell lines upon retinoic acid treatment 

      Celay Leoz, Ion Upna; Blanco Luquin, Idoia; Lázcoz, Paula Upna; Rotinen Díaz, Mirja Sofia Upna Orcid; Castresana, Javier S.; Encío Martínez, Ignacio Upna Orcid (Public Library of Science, 2013)   Artículo / Artikulua  OpenAccess
      To determine the effect of retinoic acid (RA) in neuroblastoma we treated RA sensitive neuroblastoma cell lines with 9-cis RA or ATRA for 9 days, or for 5 days followed by absence of RA for another 4 days. Both isomers ...
    • A combination of apple vinegar drink with Bacillus coagulans ameliorates high fat diet-induced body weight gain, insulin resistance and hepatic steatosis 

      Urtasun Alonso, Raquel Upna Orcid; Araña Ciordia, Miriam Upna Orcid; Pajares Villandiego, María Josefa Upna Orcid; Oneca, María Upna; Torre Hernández, Paloma Upna Orcid; Barajas Vélez, Miguel Ángel Upna Orcid; Encío Martínez, Ignacio Upna Orcid (MDPI, 2020)   Artículo / Artikulua  OpenAccess
      Obesity is a worldwide epidemic characterized by excessive fat accumulation, associated with multiple comorbidities and complications. Emerging evidence points to gut microbiome as a driving force in the pathogenesis of ...
    • Cutting down on lung cancer: Ecliptasaponin A is a novel therapeutic agent 

      Rotinen Díaz, Mirja Sofia Upna Orcid; Encío Martínez, Ignacio Upna Orcid (AME, 2020)   Artículo / Artikulua  OpenAccess
      This article is a comment of 'Han J, Lv W, Sheng H, et al. Ecliptasaponin A induces apoptosis through the activation of ASK1/JNK pathway and autophagy in human lung cancer cells. Ann Transl Med 2019;7:539'.
    • A diphenyldiselenide derivative induces autophagy via JNK in HTB-54 lung cancer cells 

      Díaz, Marta; González, Roncesvalles; Plano, Daniel; Palop, Juan Antonio; Sanmartín, Carmen; Encío Martínez, Ignacio Upna Orcid (Wiley, 2017)   Artículo / Artikulua  OpenAccess
      Symmetric aromatic diselenides are potential anticancer agents with strong cytotoxic activity. In this study, the in vitro anticancer activities of a novel series of diarylseleno derivatives from the diphenyldiselenide ...
    • Efecto de los probióticos Bifidobacterium y Lactobacilus gasseri sobre las acciones de la quercetina en cultivos celulares de cáncer de colon 

      Alfaro Larraya, María Upna (2014)   Tesis doctoral / Doktoretza tesia  OpenAccess
      La alimentación y la nutrición, junto con la actividad física, se encuentran entre los factores más determinantes para el desarrollo de enfermedades como el cáncer colorrectal,92 que en un 90% de los casos está asociado ...
    • Enzalutamida como radiopotenciador de líneas celulares de cáncer de próstata 

      Barrado Los Arcos, Marta Upna (2021)   Tesis doctoral / Doktoretza tesia  OpenAccess
      En este trabajo evaluamos el papel de enzalutamida como potenciador de la radioterapia en líneas celulares de cáncer de próstata, sirviendo como experimento de apoyo de investigación básica para investigación clínica. En ...
    • A fermented food product containing lactic acid bacteria protects ZDF rats from the development of type 2 diabetes 

      Cabello Olmo, Miriam Upna Orcid; Oneca, María Upna; Torre Hernández, Paloma Upna Orcid; Sainz, Neira; Moreno Aliaga, María J.; Guruceaga, Elizabeth; Díaz, Jesús Vicente; Encío Martínez, Ignacio Upna Orcid; Barajas Vélez, Miguel Ángel Upna Orcid; Araña Ciordia, Miriam Upna Orcid (MDPI, 2019)   Artículo / Artikulua  OpenAccess
      Type 2 diabetes (T2D) is a complex metabolic disease, which involves a maintained hyperglycemia due to the development of an insulin resistance process. Among multiple risk factors, host intestinal microbiota has received ...
    • Frequent promoter hypermethylation of RASSF1A and CASP8 in neuroblastoma 

      Lázcoz, Paula Upna; Muñoz, Jorge; Nistal, Manuel; Pestaña, Ángel; Encío Martínez, Ignacio Upna Orcid; Sáez Castresana, Javier (BioMed Central, 2006)   Artículo / Artikulua  OpenAccess
      Background: Epigenetic alterations and loss of heterozygosity are mechanisms of tumor suppressor gene inactivation. A new carcinogenic pathway, targeting the RAS effectors has recently been documented. RASSF1A, on 3p21.3, ...
    • Human microbiota network: unveiling potential crosstalk between the different microbiota ecosystems and their role in health and disease 

      Martínez, José E.; Vargas González, Augusto Upna Orcid; Pérez-Sánchez, Tania Upna Orcid; Encío Martínez, Ignacio Upna Orcid; Cabello Olmo, Miriam Upna Orcid; Barajas Vélez, Miguel Ángel Upna Orcid (MDPI, 2021)   Artículo / Artikulua  OpenAccess
      The human body is host to a large number of microorganisms which conform the human microbiota, that is known to play an important role in health and disease. Although most of the microorganisms that coexist with us are ...
    • In vitro assessment of the role of p53 on chemotherapy treatments in neuroblastoma cell lines 

      Blanco Luquin, Idoia; Lázcoz, Paula Upna; Celay Leoz, Ion Upna; Castresana, Javier S.; Encío Martínez, Ignacio Upna Orcid (MDPI, 2021)   Artículo / Artikulua  OpenAccess
      Neuroblastoma is the most frequent malignant extracranial solid tumor of infancy. The overall objective of this work consists of determining the presence of alterations in the p53/MDM2 /p14ARF signaling pathway in neuroblastoma ...
    • Influence of storage temperature and packaging on bacteria and yeast viability in a plant-based fermented food 

      Cabello Olmo, Miriam Upna Orcid; Oneca, María Upna; Torre Hernández, Paloma Upna Orcid; Díaz, Jesús Vicente; Encío Martínez, Ignacio Upna Orcid; Barajas Vélez, Miguel Ángel Upna Orcid; Araña Ciordia, Miriam Upna Orcid (MDPI, 2020)   Artículo / Artikulua  OpenAccess
      Optimization of food storage has become a central issue for food science and biotechnology, especially in the field of functional foods. The aim of this work was to investigate the influence of different storage strategies ...
    • Morphological and biochemical characterization of a cell death process induced by E3, a new synthetic diarylsulfonilurea analogue 

      Alonso Roldán, Marta Upna; Miglaccio, M.; Encío Martínez, Ignacio Upna Orcid; Asumendi, A.; Martínez Merino, Víctor Upna Orcid; Hilario, E.; García, M. (Hindawi, 2001)   Otros / Bestelakoak  OpenAccess
      With a view to finding new compounds with improved antitumoral activity and reduced secondary effects, our group, using theoretical structure-activity studies, has designed several analogues and derivatives of ...
    • New formulation of a methylseleno-aspirin analog with anticancer activity towards colon cancer 

      Ruberte, Ana Carolina; González Gaitano, Gustavo; Sharma, Arun K.; Aydillo, Carlos; Encío Martínez, Ignacio Upna Orcid; Sanmartín, Carmen; Plano, Daniel (MDPI, 2020)   Artículo / Artikulua  OpenAccess
      Aspirin (ASA) has attracted wide interest of numerous scientists worldwide thanks to its chemopreventive and chemotherapeutic effects, particularly in colorectal cancer (CRC). Incorporation of selenium (Se) atom into ASA ...
    • Novel methylselenoesters as antiproliferative agents 

      Díaz Argelich, Nuria; Encío Martínez, Ignacio Upna Orcid; Plano, Daniel; Fernandes, Aristi P.; Palop, Juan Antonio; Sanmartín, Carmen (MDPI, 2017)   Artículo / Artikulua  OpenAccess
      Selenium (Se) compounds are potential therapeutic agents in cancer. Importantly, the biological effects of Se compounds are exerted by their metabolites, with methylselenol (CH3SeH) being one of the key executors. In this ...
    • Novel N,N′-disubstituted acylselenoureas as potential antioxidant and cytotoxic agents 

      Ruberte, Ana Carolina; Ramos Inza, Sandra; Aydillo, Carlos; Talavera, Irene; Encío Martínez, Ignacio Upna Orcid; Plano, Daniel; Sanmartín, Carmen (MDPI, 2020)   Artículo / Artikulua  OpenAccess
      Selenium compounds are pivotal in medicinal chemistry for their antitumoral and antioxidant properties. Forty seven acylselenoureas have been designed and synthesized following a fragment-based approach. Different scaffolds, ...
    • A novel prognostic biomarker panel for early‐stage colon carcinoma 

      Azcue Sanroman, Pablo; Guerrero Setas, David; Encío Martínez, Ignacio Upna Orcid; Ibáñez Beroiz, B. Upna Orcid; Mercado Gutiérrez, María R.; Vera, Ruth; Gómez Dorronsoro, María Luisa (MDPI, 2021)   Artículo / Artikulua  OpenAccess
      Molecular characterization of colorectal cancer has helped us understand better the biology of the disease. However, previous efforts have yet to provide significant clinical value in order to be integrated into clinical ...
    • Novel selenadiazole derivatives as selective antitumor and radical scavenging agents 

      Ruberte, Ana Carolina; Plano, Daniel; Encío Martínez, Ignacio Upna Orcid; Aydillo, Carlos; Sharma, Arun K.; Sanmartín, Carmen (Elsevier, 2018)   Artículo / Artikulua  OpenAccess
      Twenty-seven novel benzo[c][1,2,5]selenadiazole-5-carboxylic acid (BSCA) derivatives were designed and synthesized. Anti-proliferative activity of these structures was tested in vitro against a panel of five human cancer ...
    • Organoseleno cytostatic derivatives: autophagic cell death with AMPK and JNK activation 

      Garnica, Pablo; Encío Martínez, Ignacio Upna Orcid; Plano, Daniel; Palop, Juan Antonio; Sanmartín, Carmen (Elsevier Masson SAS, 2019)   Artículo / Artikulua  OpenAccess
      Selenocyanates and diselenides are potential antitumor agents. Here we report two series of selenium derivatives related to selenocyanates and diselenides containing carboxylic, amide and imide moieties. These compounds ...
    • PD-L1 as a prognostic factor in early-stage colon carcinoma within the immunohistochemical molecular subtype classification 

      Azcue Sanroman, Pablo; Encío Martínez, Ignacio Upna Orcid; Guerrero Setas, David; Suarez Alecha, Javier; Galbete Jiménez, Arkaitz Upna Orcid; Mercado Gutiérrez, María R.; Vera, Ruth; Gómez Dorronsoro, María Luisa (MDPI, 2021)   Artículo / Artikulua  OpenAccess
      Colorectal cancer (CRC) is a very heterogeneous disease. Efforts to characterize and search for biomarkers for these patients are currently ongoing in the hope of establishing a more targeted therapeutic approach. The role ...