Listar por autor UPNA "Encío Martínez, Ignacio"
Mostrando ítems 1-20 de 31
-
Actionable driver events in small cell lung cancer
Gutiérrez Núñez, Mirian; Zamora Álvarez, Irene; Freeman, Michael R.; Encío Martínez, Ignacio
; Rotinen Díaz, Mirja Sofia (MDPI, 2024)
Artículo / Artikulua 
Small cell lung cancer (SCLC) stands out as the most aggressive form of lung cancer, characterized by an extremely high proliferation rate and a very poor prognosis, with a 5-year survival rate that falls below 7%. ... -
Antidiabetic effects of Pediococcus acidilactici pA1c on HFD-induced mice
Cabello Olmo, Miriam; Oneca, María; Pajares Villandiego, María Josefa ; Jiménez, Maddalen; Ayo, Josune; Encío Martínez, Ignacio ; Barajas Vélez, Miguel Ángel ; Araña Ciordia, Miriam (MDPI, 2022)
Artículo / Artikulua
Prediabetes (PreD), which is associated with impaired glucose tolerance and fasting blood glucose, is a potential risk factor for type 2 diabetes mellitus (T2D). Growing evidence suggests the role of the gastrointestinal ... -
Changes in gene expression profiling of apoptotic genes in neuroblastoma cell lines upon retinoic acid treatment
Celay Leoz, Ion; Blanco Luquin, Idoia; Lázcoz, Paula ; Rotinen Díaz, Mirja Sofia ; Castresana, Javier S.; Encío Martínez, Ignacio (Public Library of Science, 2013)
Artículo / Artikulua
To determine the effect of retinoic acid (RA) in neuroblastoma we treated RA sensitive neuroblastoma cell lines with 9-cis RA or ATRA for 9 days, or for 5 days followed by absence of RA for another 4 days. Both isomers ... -
A combination of apple vinegar drink with Bacillus coagulans ameliorates high fat diet-induced body weight gain, insulin resistance and hepatic steatosis
Urtasun Alonso, Raquel ; Araña Ciordia, Miriam ; Pajares Villandiego, María Josefa ; Oneca, María ; Torre Hernández, Paloma ; Barajas Vélez, Miguel Ángel ; Encío Martínez, Ignacio (MDPI, 2020)
Artículo / Artikulua
Obesity is a worldwide epidemic characterized by excessive fat accumulation, associated with multiple comorbidities and complications. Emerging evidence points to gut microbiome as a driving force in the pathogenesis of ... -
Cutting down on lung cancer: Ecliptasaponin A is a novel therapeutic agent
Rotinen Díaz, Mirja Sofia ; Encío Martínez, Ignacio (AME, 2020)
Artículo / Artikulua
This article is a comment of 'Han J, Lv W, Sheng H, et al. Ecliptasaponin A induces apoptosis through the activation of ASK1/JNK pathway and autophagy in human lung cancer cells. Ann Transl Med 2019;7:539'. -
Design, synthesis and anticancer evaluation of novel Se-NSAID hybrid molecules: identification of a Se-indomethacin analog as a potential therapeutic for breast cancer
Ramos Inza, Sandra; Encío Martínez, Ignacio ; Raza, Asif; Sharma, Arun K.; Sanmartín, Carmen; Plano, Daniel (Elsevier, 2022)
Artículo / Artikulua
A total of twenty-five novel carboxylic acid, methylester, methylamide or cyano nonsteroidal anti-inflammatory drug (NSAID) derivatives incorporating Se in the chemical form of selenoester were reported. Twenty Se-NSAID ... -
A diphenyldiselenide derivative induces autophagy via JNK in HTB-54 lung cancer cells
Díaz, Marta; González, Roncesvalles; Plano, Daniel; Palop, Juan Antonio; Sanmartín, Carmen; Encío Martínez, Ignacio (Wiley, 2017)
Artículo / Artikulua
Symmetric aromatic diselenides are potential anticancer agents with strong cytotoxic activity. In this study, the in vitro anticancer activities of a novel series of diarylseleno derivatives from the diphenyldiselenide ... -
Efecto de los probióticos Bifidobacterium y Lactobacilus gasseri sobre las acciones de la quercetina en cultivos celulares de cáncer de colon
Alfaro Larraya, María (2014)
Tesis doctoral / Doktoretza tesia
La alimentación y la nutrición, junto con la actividad física, se encuentran entre los factores más determinantes para el desarrollo de enfermedades como el cáncer colorrectal,92 que en un 90% de los casos está asociado ... -
Enzalutamida como radiopotenciador de líneas celulares de cáncer de próstata
Barrado Los Arcos, Marta (2021)
Tesis doctoral / Doktoretza tesia
En este trabajo evaluamos el papel de enzalutamida como potenciador de la radioterapia en líneas celulares de cáncer de próstata, sirviendo como experimento de apoyo de investigación básica para investigación clínica. En ... -
A fermented food product containing lactic acid bacteria protects ZDF rats from the development of type 2 diabetes
Cabello Olmo, Miriam ; Oneca, María ; Torre Hernández, Paloma ; Sainz, Neira; Moreno Aliaga, María J.; Guruceaga, Elizabeth; Díaz, Jesús Vicente; Encío Martínez, Ignacio ; Barajas Vélez, Miguel Ángel ; Araña Ciordia, Miriam (MDPI, 2019)
Artículo / Artikulua
Type 2 diabetes (T2D) is a complex metabolic disease, which involves a maintained hyperglycemia due to the development of an insulin resistance process. Among multiple risk factors, host intestinal microbiota has received ... -
First generation of antioxidant precursors for bioisosteric Se-NSAIDs: design, synthesis, and in vitro and in vivo anticancer evaluation
Ramos Inza, Sandra; Aliaga, César; Encío Martínez, Ignacio ; Raza, Asif; Sharma, Arun K.; Aydillo, Carlos; Martínez-Sáez, Nuria; Sanmartín, Carmen; Plano, Daniel (MDPI, 2023)
Artículo / Artikulua
The introduction of selenium (Se) into organic scaffolds has been demonstrated to be a promising framework in the field of medicinal chemistry. A novel design of nonsteroidal anti-inflammatory drug (NSAID) derivatives based ... -
Frequent promoter hypermethylation of RASSF1A and CASP8 in neuroblastoma
Lázcoz, Paula; Muñoz, Jorge; Nistal, Manuel; Pestaña, Ángel; Encío Martínez, Ignacio ; Sáez Castresana, Javier (BioMed Central, 2006)
Artículo / Artikulua
Background: Epigenetic alterations and loss of heterozygosity are mechanisms of tumor suppressor gene inactivation. A new carcinogenic pathway, targeting the RAS effectors has recently been documented. RASSF1A, on 3p21.3, ... -
Human microbiota network: unveiling potential crosstalk between the different microbiota ecosystems and their role in health and disease
Martínez, José E.; Vargas González, Augusto ; Pérez Sánchez, Tania ; Encío Martínez, Ignacio ; Cabello Olmo, Miriam ; Barajas Vélez, Miguel Ángel (MDPI, 2021)
Artículo / Artikulua
The human body is host to a large number of microorganisms which conform the human microbiota, that is known to play an important role in health and disease. Although most of the microorganisms that coexist with us are ... -
In vitro assessment of the role of p53 on chemotherapy treatments in neuroblastoma cell lines
Blanco Luquin, Idoia; Lázcoz, Paula; Celay Leoz, Ion ; Castresana, Javier S.; Encío Martínez, Ignacio (MDPI, 2021)
Artículo / Artikulua
Neuroblastoma is the most frequent malignant extracranial solid tumor of infancy. The overall objective of this work consists of determining the presence of alterations in the p53/MDM2 /p14ARF signaling pathway in neuroblastoma ... -
Influence of storage temperature and packaging on bacteria and yeast viability in a plant-based fermented food
Cabello Olmo, Miriam ; Oneca, María ; Torre Hernández, Paloma ; Díaz, Jesús Vicente; Encío Martínez, Ignacio ; Barajas Vélez, Miguel Ángel ; Araña Ciordia, Miriam (MDPI, 2020)
Artículo / Artikulua
Optimization of food storage has become a central issue for food science and biotechnology, especially in the field of functional foods. The aim of this work was to investigate the influence of different storage strategies ... -
Morphological and biochemical characterization of a cell death process induced by E3, a new synthetic diarylsulfonilurea analogue
Alonso Roldán, Marta; Miglaccio, M.; Encío Martínez, Ignacio ; Asumendi, A.; Martínez Merino, Víctor ; Hilario, E.; García, M. (Hindawi, 2001)
Otros / Bestelakoak
With a view to finding new compounds with improved antitumoral activity and reduced secondary effects, our group, using theoretical structure-activity studies, has designed several analogues and derivatives of ... -
New formulation of a methylseleno-aspirin analog with anticancer activity towards colon cancer
Ruberte, Ana Carolina; González Gaitano, Gustavo; Sharma, Arun K.; Aydillo, Carlos; Encío Martínez, Ignacio ; Sanmartín, Carmen; Plano, Daniel (MDPI, 2020)
Artículo / Artikulua
Aspirin (ASA) has attracted wide interest of numerous scientists worldwide thanks to its chemopreventive and chemotherapeutic effects, particularly in colorectal cancer (CRC). Incorporation of selenium (Se) atom into ASA ... -
Novel acylselenourea derivatives: dual molecules with anticancer and radical scavenging activity
Astráin-Redín, Nora; Raza, Asif; Encío Martínez, Ignacio ; Sharma, Arun K.; Plano, Daniel; Sanmartín, Carmen (MDPI, 2023)
Artículo / Artikulua
Oxidative stress surrounding cancer cells provides them with certain growth and survival advantages necessary for disease progression. In this context, Se-containing molecules have gained attention due to their anticancer ... -
Novel methylselenoesters as antiproliferative agents
Díaz Argelich, Nuria; Encío Martínez, Ignacio ; Plano, Daniel; Fernandes, Aristi P.; Palop, Juan Antonio; Sanmartín, Carmen (MDPI, 2017)
Artículo / Artikulua
Selenium (Se) compounds are potential therapeutic agents in cancer. Importantly, the biological effects of Se compounds are exerted by their metabolites, with methylselenol (CH3SeH) being one of the key executors. In this ... -
Novel N,N′-disubstituted acylselenoureas as potential antioxidant and cytotoxic agents
Ruberte, Ana Carolina; Ramos Inza, Sandra; Aydillo, Carlos; Talavera, Irene; Encío Martínez, Ignacio ; Plano, Daniel; Sanmartín, Carmen (MDPI, 2020)
Artículo / Artikulua
Selenium compounds are pivotal in medicinal chemistry for their antitumoral and antioxidant properties. Forty seven acylselenoureas have been designed and synthesized following a fragment-based approach. Different scaffolds, ...
